DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hel89B and CHD1L

DIOPT Version :9

Sequence 1:NP_001287351.1 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_004275.4 Gene:CHD1L / 9557 HGNCID:1916 Length:897 Species:Homo sapiens


Alignment Length:562 Identity:180/562 - (32%)
Similarity:274/562 - (48%) Gaps:83/562 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  1348 VELRCYQQAGINWLWFLNKYNLHG--ILCDDMGLGKTLQTICI---LAGDHMHRQTANLANLPSL 1407
            :.||.||..|:|||  ..:::...  ||.|:||||||.|||.:   ||| .::.:.      |.|
Human    44 IHLRSYQLEGVNWL--AQRFHCQNGCILGDEMGLGKTCQTIALFIYLAG-RLNDEG------PFL 99

  Fly  1408 VICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDI--GTKCNLVVASYDTVRKDID 1470
            ::||.::..:|..|:::|   ...|..:.|.|....|..|:.|:  .::.::::.:|:...||..
Human   100 ILCPLSVLSNWKEEMQRF---APGLSCVTYAGDKEERACLQQDLKQESRFHVLLTTYEICLKDAS 161

  Fly  1471 FFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLG 1535
            |.....::..|:||.|.:||..:...|.:........|:|:||||||::.||:||..|:.|....
Human   162 FLKSFPWSVLVVDEAHRLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFS 226

  Fly  1536 TEK--QFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQD 1598
            .|:  .|:||:          :...||.|:.    ..||:.:.||||||||.:|..:||.|....
Human   227 KEEVGDFIQRY----------QDIEKESESA----SELHKLLQPFLLRRVKAEVATELPKKTEVV 277

  Fly  1599 LLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVL 1663
            :...:|.||.:.|:...   :|| ||...:.::..:..:|:         |..|:...:||.|..
Human   278 IYHGMSALQKKYYKAIL---MKD-LDAFENETAKKVKLQNI---------LSQLRKCVDHPYLFD 329

  Fly  1664 RQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDI 1728
            ....|..:|...|.         |.|.||..|.:||.....|       .||.|:|.|:..||||
Human   330 GVEPEPFEVGDHLT---------EASGKLHLLDKLLAFLYSG-------GHRVLLFSQMTQMLDI 378

  Fly  1729 VEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFV 1793
            ::..:..|   ..:|.|:||||...:|...:.||...| |.|.||:|..||:|:|||.|||||||
Human   379 LQDYMDYR---GYSYERVDGSVRGEERHLAIKNFGQQP-IFVFLLSTRAGGVGMNLTAADTVIFV 439

  Fly  1794 EHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTM 1858
            :.|:||..||||..|||||||.|.|.|.|||.|:::||.:......|:...|.::...:.:|...
Human   440 DSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQ 504

  Fly  1859 GTS-----QIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTI 1895
            ..:     |:.::...|.||          ..||.|.:|:.|
Human   505 KPAADADLQLSEILKFGLDK----------LLASEGSTMDEI 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_001287351.1 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:288874
HEAT repeat 1234..1261 CDD:293787
HEAT repeat 1269..1298 CDD:293787
SNF2_N 1353..1662 CDD:278600 93/317 (29%)
DEXDc 1370..1514 CDD:238005 42/150 (28%)
Helicase_C 1689..1813 CDD:278689 56/123 (46%)
CHD1LNP_004275.4 SNF2_N 46..699 CDD:331286 180/560 (32%)
DEAH box 174..177 2/2 (100%)
Required for helicase activity. /evidence=ECO:0000269|PubMed:29220653 615..673
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..654
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..711
Macro_Poa1p_like_SNF2 716..866 CDD:239447
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D61251at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.