Protein Alignment Hel89B and CHD1L

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_004275.4
• Gene: CHD1L / 9557
• HGNCID: 1916
• Length: 897
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 180/562 - (32%)
• Similarity: 274/562 - (48%)
• Gaps: 83/562 - (14%)

  Fly  1348 VELRCYQQAGINWLWFLNKYNLHG--ILCDDMGLGKTLQTICI---LAGDHMHRQTANLANLPSL 1407
            :.||.||..|:|||  ..:::...  ||.|:||||||.|||.:   ||| .::.:.      |.|
Human    44 IHLRSYQLEGVNWL--AQRFHCQNGCILGDEMGLGKTCQTIALFIYLAG-RLNDEG------PFL 99

  Fly  1408 VICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDI--GTKCNLVVASYDTVRKDID 1470
            ::||.::..:|..|:::|   ...|..:.|.|....|..|:.|:  .::.::::.:|:...||..
Human   100 ILCPLSVLSNWKEEMQRF---APGLSCVTYAGDKEERACLQQDLKQESRFHVLLTTYEICLKDAS 161

  Fly  1471 FFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLG 1535
            |.....::..|:||.|.:||..:...|.:........|:|:||||||::.||:||..|:.|....
Human   162 FLKSFPWSVLVVDEAHRLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFS 226

  Fly  1536 TEK--QFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQD 1598
            .|:  .|:||:          :...||.|:.    ..||:.:.||||||||.:|..:||.|....
Human   227 KEEVGDFIQRY----------QDIEKESESA----SELHKLLQPFLLRRVKAEVATELPKKTEVV 277

  Fly  1599 LLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVL 1663
            :...:|.||.:.|:...   :|| ||...:.::..:..:|:         |..|:...:||.|..
Human   278 IYHGMSALQKKYYKAIL---MKD-LDAFENETAKKVKLQNI---------LSQLRKCVDHPYLFD 329

  Fly  1664 RQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDI 1728
            ....|..:|...|.         |.|.||..|.:||.....|       .||.|:|.|:..||||
Human   330 GVEPEPFEVGDHLT---------EASGKLHLLDKLLAFLYSG-------GHRVLLFSQMTQMLDI 378

  Fly  1729 VEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFV 1793
            ::..:..|   ..:|.|:||||...:|...:.||...| |.|.||:|..||:|:|||.|||||||
Human   379 LQDYMDYR---GYSYERVDGSVRGEERHLAIKNFGQQP-IFVFLLSTRAGGVGMNLTAADTVIFV 439

  Fly  1794 EHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTM 1858
            :.|:||..||||..|||||||.|.|.|.|||.|:::||.:......|:...|.::...:.:|...
Human   440 DSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQ 504

  Fly  1859 GTS-----QIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTI 1895
            ..:     |:.::...|.||          ..||.|.:|:.|
Human   505 KPAADADLQLSEILKFGLDK----------LLASEGSTMDEI 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	170/509 (33%)
CHD1L	NP_004275.4	PLN03142	46..699	CDD:215601	180/560 (32%)
		DEAH box	174..177		2/2 (100%)
		Regulatory linker segment (RLS). /evidence=ECO:0000269|PubMed:33357431	601..635
		Required for ATPase activity. /evidence=ECO:0000269|PubMed:29220653	615..673
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..654
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..711
		Macro_Poa1p-like_SNF2	716..866	CDD:394880