Protein Alignment Hel89B and rapA

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_414601.1
• Gene: rapA / 948523
• ECOCYCID: EG11083
• Length: 968
• Species: Escherichia coli
• Alignment Length: 713
• Identity: 147/713 - (20%)
• Similarity: 252/713 - (35%)
• Gaps: 177/713 - (24%)

  Fly  1278 LGAMSDPDES-VRLLSTHCFANLVQLMPLD----GKTEQLKSDPLQARKTRDREFLDYLFNPKSI 1337
            :|...|.:|| |.|......:.||...|.|    |:.:::           ||..|.|.....|.
E. coli    84 IGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRM-----------DRFALRYRARKYSS 137

  Fly  1338 PNYKVPVP---------ISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDH 1393
            ..:::|..         |..:|......|       .::....:|.|::|||||::     ||..
E. coli   138 EQFRMPYSGLRGQRTSLIPHQLNIAHDVG-------RRHAPRVLLADEVGLGKTIE-----AGMI 190

  Fly  1394 MHRQTANLANLPSLVICPPTLTGHWVYEVEK-------FLDQGSVLRPLHYYGFPVGREKLRSDI 1451
            :|:|..:.|....|:|.|.||...|:.|:.:       ..|........|....|...|:
E. coli   191 LHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQ----- 250

  Fly  1452 GTKCNLVVASYDTVRKD---IDFFSGIHFNYCVLDEGHII---KNGKTKSSKAIKRLKANH---R 1507
                 ||:.|.|..|:.   ::......::..|:||.|.:   ::..::..:||::| |.|   .
E. coli   251 -----LVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQL-AEHVPGV 309

  Fly  1508 LILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFV--QRFSRPILSSRDAKSSAKEQEAGVLAMEA 1570
            |:|:.||.|..:...::....|.|.......|||  |:..||:              |..:||
E. coli   310 LLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPV--------------ADAVAM-- 358

  Fly  1571 LHRQVLPFLL--RRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSA- 1632
                    ||  .::..|.|..|...|.:.   ::.||......|..            |:.||
E. coli   359 --------LLAGNKLSNDELNMLGEMIGEQ---DIEPLLQAANSDSE------------DAQSAR 400

  Fly  1633 ----SMVTENLSAKTHIFQALRYLQNVCNHPKLVLR--------QSEELTKVTSQLALSNSSLD- 1684
                ||:.:.......:|:..|  ..|...||..|.        |.:...||:..:....|:.|
E. coli   401 QELVSMLMDRHGTSRVLFRNTR--NGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDR 463

  Fly  1685 --DIEHSAKL---------------PALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQD 1732
              |:.:..::               |.::.|:     |..|...|| :.|:.|...|....:||.
E. coli   464 ARDMLYPERIYQEFEGDNATWWNFDPRVEWLM-----GYLTSHRSQ-KVLVICAKAATALQLEQV 522

  Fly  1733 LLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDW 1797
            |..|.  .:........:...:|......|..:.:...:||.:.:|..|.|...|..::..:..:
E. coli   523 LRERE--GIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPF 585

  Fly  1798 NPMKDL--QAMDRAHRIGQKKVVNVYRLITRNSLEEKIM-----GLQKFK--ILTANTVVSAENA 1853
            ||  ||  |.:.|..||||...:.::......:.:..::     ||..|:  ..|..|:..:...
E. coli   586 NP--DLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYN 648

  Fly  1854 SL--------QTMGTSQIFDLFNGGKDKGAESGSSAVQGT-------ASGGMSMNTIIENLPE 1901
            .|        ||.|..   ||....:::.....:...||.       ::||.....:.|::.|
E. coli   649 DLINYLASPDQTEGFD---DLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEE 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	119/575 (21%)
rapA	NP_414601.1	PRK04914	2..966	CDD:235319	147/713 (21%)