DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and Smarca1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001277637.1	Gene:	Smarca1 / 93761	MGIID:	1935127	Length:	1062	Species:	Mus musculus

Alignment Length:	783	Identity:	236/783 - (30%)
Similarity:	351/783 - (44%)	Gaps:	143/783 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1217 AVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI-------------ERVVSRLQIKVV- 1267
            |.:|..||..|: .||.|..|  |  ....:.:||..|.             |::.|..|:|:.
Mouse    10 ATVAVSDARATV-VVVEDEQP--G--PSTFKEEGAAAAATEGTTATEKGEKKEKITSPFQLKLAA 69

  Fly  1268 -----------PYIVLLV-VPLLGAMSDPDESVR----LLSTHCFANLVQ-------LMPLDGK- 1308
                       .|...:| :||     ..|.:.|    |..|..||:.:|       ..||:.|
Mouse    70 KASKSEKEMDPEYEEKMVNMPL-----KADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKL 129

  Fly  1309 -TEQLKSDPLQA---------RKTRDREFLDYLFNPKSIPNYKVPVPISVE------LRCYQQAG 1357
             ..::|.|..|:         |:|...|..:.|...:...|..|...:|..      ||.||..|
Mouse   130 ARPRVKKDDKQSLISVGDYRHRRTEQEEDEELLSESRKTSNVCVRFEVSPSYVKGGPLRDYQIRG 194

  Fly  1358 INWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEV 1422
            :|||..|.:..::|||.|:||||||||||.:|.....:|....    |.:|:.|.:...:|:.|.
Mouse   195 LNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPG----PHMVLVPKSTLHNWMNEF 255

  Fly  1423 EKFLDQGSVLRPLHYYGFPVGREKLRSD--IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEG 1485
            ::::..   ||.:.:.|....|.....|  :..:.::.|.||:.|.|:...|...|:.|.|:||.
Mouse   256 KRWVPS---LRVICFVGDKDVRAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEA 317

  Fly  1486 HIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILS 1550
            |.|||.|:|.|:.::..|:.:||:|:|||:|||:.|||:|.:||:|....:...|...|
Mouse   318 HRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF------ 376

  Fly  1551 SRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFS 1615
              |.|:...:|:    .:|.||..:.||||||:|.||.|.||||....:...||.:|...|
Mouse   377 --DTKNCLGDQK----LVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWY---- 431

  Fly  1616 NKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSN 1680
            .|.|...:|.|..|....        |..:...|..|:..||||.|...........|.:..:.|
Mouse   432 TKILMKDIDVLNSSGKMD--------KMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVGN 488

  Fly  1681 SSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLR 1745
                    |.|:.||.:||    ..::.:.   .|.|||.|:..:|||:|...:.|   ...|.|
Mouse   489 --------SGKMVALDKLL----ARIKEQG---SRVLIFSQMTRLLDILEDYCMWR---GYEYSR 535

  Fly  1746 LDGSVPASQRQDIVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRA 1809
            |||..|..:|::.::.||: :.|..:.:|:|..||||:||..||.||..:.||||..||||||||
Mouse   536 LDGQTPHEEREEAIDAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRA 600

  Fly  1810 HRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVS------------AENASLQTM--GT 1860
            |||||||.|.|:||||.|::||:|:...:.|:...:.|:.            |:...||.:  |.
Mouse   601 HRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGA 665

  Fly  1861 SQIF-------------DLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEY 1912
            :.:|             .:...|:.|.||......:...|...:....:|.....:....|.|:.
Mouse   666 THVFACKESELTDEDIVTILERGEKKTAEMNERMQKMGESSLRNFRMDLEQSLYKFEGEDYREKQ 730

  Fly  1913 DLG 1915
            .||
Mouse   731 KLG 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787	7/39 (18%)
		HEAT repeat	1269..1298	CDD:293787	9/33 (27%)
		SNF2_N	1353..1662	CDD:278600	106/310 (34%)
		DEXDc	1370..1514	CDD:238005	49/145 (34%)
		Helicase_C	1689..1813	CDD:278689	52/124 (42%)
Smarca1	NP_001277637.1	PLN03142	2..1061	CDD:215601	236/783 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..61		6/37 (16%)
		DBINO	<73..114	CDD:290603	10/45 (22%)
		DEXDc	207..346	CDD:238005	49/145 (34%)
		DEAH box	315..318		2/2 (100%)
		Helicase_C	489..604	CDD:278689	52/124 (42%)
		HAND	750..848	CDD:286232
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..840
		SANT	851..890	CDD:238096
		SLIDE	905..1017	CDD:286233
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920