DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hel89B and BTAF1

DIOPT Version :10

Sequence 1:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_003963.1 Gene:BTAF1 / 9044 HGNCID:17307 Length:1849 Species:Homo sapiens


Alignment Length:1969 Identity:909/1969 - (46%)
Similarity:1225/1969 - (62%) Gaps:172/1969 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEA 67
            ||||||||||:||:|..||:|||:|:|||.||:||||:.||::::.||.|.:|:|||||.|.|||
Human     4 SRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSANWDTRIAAGQAVEA 68

  Fly    68 ILKQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILHK 132
            |:|.||.|.|    :|:             ..:|.:.:||..:|.| :|| |:||.||:.::|..
Human    69 IVKNVPEWNP----VPR-------------TRQEPTSESSMEDSPT-TER-LNFDRFDICRLLQH 114

  Fly   133 GARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDED 197
            ||.|:||.|.||:||:|:    .||.|..  .|::|||.:|..||||.....:|::..::..|||
Human   115 GASLLGSAGAEFEVQDEK----SGEVDPK--ERIARQRKLLQKKLGLNMGEAIGMSTEELFNDED 173

  Fly   198 VALNRSGSTYNVNAEKLPVEHLLNIKTAANGSGQAPLSCREMNRAKRKARQNTSGCSVTAVTPTC 262
            :....:.::: ||  |.|.   |......:...:|.:|.|:.|:|||.|:......|..||    
Human   174 LDYTPTSASF-VN--KQPT---LQAAELIDSEFRAGMSNRQKNKAKRMAKLFAKQRSRDAV---- 228

  Fly   263 SRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLKSTDRQEIFYSLNAA------VPDATGTWVDA 321
             ..|..||.||..             |||:|:.|..: ..|..|.|.:      :||::....:.
Human   229 -ETNEKSNDSTDG-------------EPEEKRRKIAN-VVINQSANDSKVLIDNIPDSSSLIEET 278

  Fly   322 VSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTREQMDEAHSRWLEDAA 386
            ..||||:||..|..|||:..|||||||.|.|||::..|.:..||....|.|:|.:.|..||||..
Human   279 NEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLV 343

  Fly   387 LRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQLIQHKNEWDVRH 451
            :|||||..||||||||||:|||||||||||.||.::|.|..:.|.:.|::||:|:. :.:|:|||
Human   344 IRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLT-QEQWEVRH 407

  Fly   452 GGLLGLKYVFVVREELLPIYLPQSISNILIGLLDAVDDVGAVAAATLIPVSSWLPKLLNPAQVSS 516
            |||||:||...||::::...||:.::.|:.||.|..|||.|||||:|:||...| ..|...:|..
Human   408 GGLLGIKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESL-VYLQTQKVPF 471

  Fly   517 IVKMLWDLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPRLWPFLSHSTSSVRRS 581
            |:..|||.||:.|:||::.||.|.||:::|..|...:....:.:.:||||:||||.|:.|||||:
Human   472 IINTLWDALLELDDLTASTNSIMTLLSSLLTYPQVQQCSIQQSLTVLVPRVWPFLHHTISSVRRA 536

  Fly   582 TLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWELLQQALRHIYQRILVEPQAD 646
            .|:||.||.|.       :|:|.                |.|...:|...||||:|..::|...:
Human   537 ALETLFTLLST-------QDQNS----------------SSWLIPILPDMLRHIFQFCVLESSQE 578

  Fly   647 IQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFDAGVLIRAGGDVSTPGSTSRK 711
            |..|..:||..|:..|.:..::.||||::.:|:||.|||..|..|..:|:..             
Human   579 ILDLIHKVWMELLSKASVQYVVAAACPWMGAWLCLMMQPSHLPIDLNMLLEV------------- 630

  Fly   712 RTPRIGDELGGNI---LAQSNASLKLYLGGSEATPLD--VRDANFMRARISSSRALGALSHYLVQ 771
             ..|..::.||.:   .:|:...|:.|:.|::....|  .||...||||:.:::.||||...:..
Human   631 -KARAKEKTGGKVRQGQSQNKEVLQEYIAGADTIMEDPATRDFVVMRARMMAAKLLGALCCCICD 694

  Fly   772 PAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDEPVRPGPPNLQEKLHQC 836
              |||....|...|.:...::||.|||:.||:|||...|:|..||...:..:.....:|.:|...
Human   695 --PGVNVVTQEIKPAESLGQLLLFHLNSKSALQRISVALVICEWAALQKECKAVTLAVQPRLLDI 757

  Fly   837 VSEYVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQI-EAVATTLSENLRSYP 900
            :||::||||:|:..||:..|.:..|::|....|.:.:..|..:||:||. :.|.|..:|...|:.
Human   758 LSEHLYYDEIAVPFTRMQNECKQLISSLADVHIEVGNRVNNNVLTIDQASDLVTTVFNEATSSFD 822

  Fly   901 LKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKR 965
            |.|:||..|:.:|:.:|.:..:|..|.....:......|.|:.:|..||:||||::|||||:||:
Human   823 LNPQVLQQLDSKRQQVQMTVTETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKK 887

  Fly   966 EQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPL------ETLKQ 1024
            |:...:|..:|:.:..|:.|...|.|.|||||:.|||:.|..||..||.:..|:      |..|.
Human   888 EENTLVQNYAAQCIAKLLQQCTTRTPCPNSKIIKNLCSSLCVDPYLTPCVTCPVPTQSGQENSKG 952

  Fly  1025 TPVSSEVINNCV--YYGILTL-ALQQTVTTTNTRSGAGGATTPTATTA-----PRGPGRPPTGEI 1081
            :....:.:::.|  :.||:|| ..|:......:|.|    .||.|..|     |.|    .:|.|
Human   953 STSEKDGMHHTVTKHRGIITLYRHQKAAFAITSRRG----PTPKAVKAQIADLPAG----SSGNI 1009

  Fly  1082 LSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQF 1146
            |        :||...|      |...:||.||..|:..:.:.||.::..|:......|.|.:...
Human  1010 L--------VELDEAQ------KPYLVQRRGAEFALTTIVKHFGGEMAVKLPHLWDAMVGPLRNT 1060

  Fly  1147 VK-EAYDWRLGSLLPDLG--VCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAV 1208
            :. ..:|   |..|.|.|  ...|||:|:|:.||||..:...|||.:...||.|...:.:|..||
Human  1061 IDINNFD---GKSLLDKGDSPAQELVNSLQVFETAAASMDSELHPLLVQHLPHLYMCLQYPSTAV 1122

  Fly  1209 RHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLL 1273
            |||||||:.|:::|...:||...:..:||.||.|:..::::|||||:..|:.:|.:.:|||||||
Human  1123 RHMAARCVGVMSKIATMETMNIFLEKVLPWLGAIDDSVKQEGAIEALACVMEQLDVGIVPYIVLL 1187

  Fly  1274 VVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDG---KTEQLKSDPLQARKTRDREFLDYLFNPK 1335
            |||:||.|||..:|||.::|.|||.|::||||:.   ....:.::.:|. |.::|.||:.|.:.|
Human  1188 VVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSAELIQL-KAKERHFLEQLLDGK 1251

  Fly  1336 SIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHR---- 1396
            .:.|||:||||:.|||.|||.|:|||.|||||.||||||||||||||||:||||||||.||    
Human  1252 KLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCHRAQEY 1316

  Fly  1397 ---QTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLV 1458
               :.|....|||||:||||||||||.||.||..: ..|.||||.|.|..|.:|:..: .:.||:
Human  1317 ARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSR-EYLNPLHYTGPPTERIRLQHQV-KRHNLI 1379

  Fly  1459 VASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELW 1523
            |||||.||.|||||..|.||||:|||||:|||||||.|||:|:|.||:|:|||||||||||||||
Human  1380 VASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELW 1444

  Fly  1524 SLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVL 1588
            ||||||||||||||:||..|:.:|||:||||:||::|||||||||:|||||||||||||:|||||
Human  1445 SLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVL 1509

  Fly  1589 KDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTE--NLSAKTHIFQALRY 1651
            :||||||.||..|.|||||::|||||:....|..:|:...|::.|..||  .|.|..|:||||:|
Human  1510 QDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSATLSEETEKPKLKATGHVFQALQY 1574

  Fly  1652 LQNVCNHPKLVLR-QSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIG------VQTE 1709
            |:.:||||.|||. |..|......:||:.||||.||:|:.||.||||||||||:|      ..||
Human  1575 LRKLCNHPALVLTPQHPEFKTTAEKLAVQNSSLHDIQHAPKLSALKQLLLDCGLGNGSTSESGTE 1639

  Fly  1710 S-VSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLL 1773
            | |:|||.|||||||:||||||.|||:.|||||||||||||:|..||..||:.||:|||||||||
Human  1640 SVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLL 1704

  Fly  1774 TTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQK 1838
            ||.||||||||||||||:|||||||||:||||||||||||||:||||||||||.:||||||||||
Human  1705 TTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQK 1769

  Fly  1839 FKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELW 1903
            ||:..||||:|.||:|||:|||.|:.|||...||..||...::..|.|    ||.:|:|||.:||
Human  1770 FKMNIANTVISQENSSLQSMGTDQLLDLFTLDKDGKAEKADTSTSGKA----SMKSILENLSDLW 1830

  Fly  1904 SEHQYEEEYDLGNFVQALK 1922
            .:.||:.||.|.||:.:||
Human  1831 DQEQYDSEYSLENFMHSLK 1849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787 17/24 (71%)
HEAT repeat 42..70 CDD:293787 16/27 (59%)
HEAT repeat 395..420 CDD:293787 22/24 (92%)
HEAT repeat 433..465 CDD:293787 16/31 (52%)
HEAT repeat 475..504 CDD:293787 15/28 (54%)
HEAT repeat 516..540 CDD:293787 11/23 (48%)
HEAT repeat 560..589 CDD:293787 17/28 (61%)
DUF3535 654..1138 CDD:463447 155/503 (31%)
HepA <1342..1849 CDD:440319 363/523 (69%)
BTAF1NP_003963.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..97 6/36 (17%)
Nuclear localization signal. /evidence=ECO:0000255 191..207 2/15 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..247 12/45 (27%)
HEAT repeat 286..314 CDD:293787 17/27 (63%)
HEAT 340..454 CDD:441023 64/114 (56%)
HEAT repeat 352..377 CDD:293787 22/24 (92%)
HEAT 1 385..422 18/37 (49%)
HEAT repeat 390..419 CDD:293787 15/29 (52%)
HEAT 2 426..463 18/37 (49%)
HEAT repeat 430..460 CDD:293787 15/29 (52%)
HEAT repeat 475..495 CDD:293787 10/19 (53%)
HEAT repeat 506..541 CDD:293787 15/34 (44%)
HEAT 3 513..550 20/43 (47%)
HEAT 4 554..596 14/41 (34%)
DUF3535 586..1051 CDD:463447 155/502 (31%)
HEAT 5 818..855 10/36 (28%)
HEAT 6 872..910 16/37 (43%)
HEAT repeat 1008..1033 CDD:293787 11/38 (29%)
HEAT repeat 1053..1091 CDD:293787 12/40 (30%)
HEAT 7 1102..1139 16/36 (44%)
HEAT repeat 1106..1136 CDD:293787 14/29 (48%)
HEAT repeat 1144..1171 CDD:293787 10/26 (38%)
HEAT 8 1182..1219 24/36 (67%)
HEAT repeat 1184..1213 CDD:293787 19/28 (68%)
HepA <1231..1780 CDD:440319 373/551 (68%)
DEGH box 1404..1407 2/2 (100%)

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