DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hel89B and MOT1

DIOPT Version :9

Sequence 1:NP_001287351.1 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_015243.1 Gene:MOT1 / 856023 SGDID:S000006003 Length:1867 Species:Saccharomyces cerevisiae


Alignment Length:2065 Identity:710/2065 - (34%)
Similarity:1042/2065 - (50%) Gaps:348/2065 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEA 67
            |||||..||:|||||...|..||.|:|::.|.:|.::.:||:|:..:|....||||:.||:.|..
Yeast     6 SRLDRQVILIETGSTQVVRNMAADQMGDLAKQHPEDILSLLSRVYPFLLVKKWETRVTAARAVGG 70

  Fly    68 ILKQVPPWQPEFQVLPKKERCATNTATAAAAAE-----------EDSCQSSGSNSTTASERLLSF 121
            |:...|.|.|....|..    .||..:....|:           |::.|::..|.......|.|.
Yeast    71 IVAHAPSWDPNESDLVG----GTNEGSPLDNAQVKLEHEMKIKLEEATQNNQLNLLQEDHHLSSL 131

  Fly   122 DEFDLQQILHKGARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLG 186
            .::.|.:||..|..|:.|..|:::|.        |:.|.::     |::|..:|.          
Yeast   132 SDWKLNEILKSGKVLLASSMNDYNVL--------GKADDNI-----RKQAKTDDI---------- 173

  Fly   187 VNLTDMITDEDVALNRSGSTYNVNAEKLPVEHLLNIKTAANGSGQAPLSCREMNRAKR--KARQN 249
            ...|.|:...|.| |.:.|..|..:.::........|.:|..:.:.|:...|.:.:|.  ..:..
Yeast   174 KQETSMLNASDKA-NENKSNANKKSARMLAMARRKKKMSAKNTPKHPVDITESSVSKTLLNGKNM 237

  Fly   250 TSGCSVTAVTPTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLKST-----DRQEIFYSLNA 309
            |:..:..|.:||.::.|.....:..::.|             |..::||     ::.||      
Yeast   238 TNSAASLATSPTSNQLNPKLEITEQADES-------------KLMIESTVRPLLEQHEI------ 283

  Fly   310 AVPDATGTWVDAVSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTREQM 374
                     |..:.|..:.....|..:|....||:|||||..||||:.:||.|..:....|||:.
Yeast   284 ---------VAGLVWQFQGIYELLLDNLMSENWEIRHGAALGLRELVKKHAYGVSRVKGNTREEN 339

  Fly   375 DEAHSRWLEDAALRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQ 439
            :..:||.|||.|.|||.|..||||||:|.|.|||||||:.||.|..|:..::::...:|.|.|.|
Yeast   340 NLRNSRSLEDLASRLLTVFALDRFGDYVYDTVVAPVRESVAQTLAALLIHLDSTLSIKIFNCLEQ 404

  Fly   440 LIQH--------KNEWDVRHGGLLGLKYVFVVREELLPIY--LPQSISNILIGLLDAVDDVGAVA 494
            |:..        ...|:..||||||::|...::...|..:  |...:..:|.||..:.|||.:||
Yeast   405 LVLQDPLQTGLPNKIWEATHGGLLGIRYFVSIKTNFLFAHGLLENVVRIVLYGLNQSDDDVQSVA 469

  Fly   495 AATLIPVSSWLPKLLNPAQVSSIVKMLWDLL--LDQDELTSACNSFMGLLAAILC---------- 547
            |:.|.|::|...| ||.:.:..:|..:|.||  || |:::|:..|.|.|||. ||          
Yeast   470 ASILTPITSEFVK-LNNSTIEILVTTIWSLLARLD-DDISSSVGSIMDLLAK-LCDHQEVLDILK 531

  Fly   548 ---LPNAARWVEMEPMAILVPRLWPFLSHSTSSVRRSTLKTLMTLTSADRVKSEPKDENQVKEEA 609
               |.:.:.|    ....|||:|:|||.||.|||||:.|..|:...|             :|:::
Yeast   532 NKALEHPSEW----SFKSLVPKLYPFLRHSISSVRRAVLNLLIAFLS-------------IKDDS 579

  Fly   610 DKEEMKLNFGVSDWKWELLQQALRHIYQRILVEPQADIQALARQVWSNLIQHADL----GALLHA 670
            .|          :|   |..:..|.::|.||:|...::..|:..|:..|::|..:    ..|.|.
Yeast   580 TK----------NW---LNGKVFRLVFQNILLEQNPELLQLSFDVYVALLEHYKVKHTEKTLDHV 631

  Fly   671 ACPFVSSWICLSMQP-----PRLAFDAGVLIRAG----------GDVSTPGSTSRKRTPRIGDEL 720
            ....:...:.|...|     ...|.::..:::..          ..:|...:.|....|:..:.:
Yeast   632 FSKHLQPILHLLNTPVGEKGKNYAMESQYILKPSQHYQLHPEKKRSISETTTDSDIPIPKNNEHI 696

  Fly   721 GGNILAQSNASLKLYLGGSEATPLDVRDANFMRARISSSRALG-ALSHYLVQPAPGVVYTPQTES 784
                    |....:..|......|||    .:..||..::|.. .||.:            |..:
Yeast   697 --------NIDAPMIAGDITLLGLDV----ILNTRIMGAKAFALTLSMF------------QDST 737

  Fly   785 PTDCYTKVLLGHLNAHSAVQRIVCGLII----AFWALEDEPVRPGPPNLQEKLHQCV-------- 837
            ....:|.||:..|....:..|::.|:|:    :.| |:..|.....|:...::...|        
Yeast   738 LQSFFTNVLVRCLELPFSTPRMLAGIIVSQFCSSW-LQKHPEGEKLPSFVSEIFSPVMNKQLLNR 801

  Fly   838 SEYVYYDEVAISLTRLLQEAQDFIAT------LKQNKIPINDFNNAKILTLDQIE----AVATTL 892
            .|:..:.|:..||..|..:.|..:||      |.|.|:|     |..|:...:.|    |.....
Yeast   802 DEFPVFRELVPSLKALRTQCQSLLATFVDVGMLPQYKLP-----NVAIVVQGETEAGPHAFGVET 861

  Fly   893 SENL-------------RSYPL---KPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGA 941
            :|.:             .||.|   ||     ||:.:..:..:.............|..|..|.:
Yeast   862 AEKVYGEYYDKMFKSMNNSYKLLAKKP-----LEDSKHRVLMAINSAKESAKLRTGSILANYASS 921

  Fly   942 ICALHCLPDKLNPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNP-SPNSKILNNLCTLL 1005
            |.....||.||||:::.||:|:|.|:..:||.::.|.:|||:.|:.:.|. :.:.||:.|||..|
Yeast   922 ILLFDGLPLKLNPIIRSLMDSVKEERNEKLQTMAGESVVHLIQQLLENNKVNVSGKIVKNLCGFL 986

  Fly  1006 RSDPEFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAP 1070
            ..|....|...:..|..::               ||||                           
Yeast   987 CVDTSEVPDFSVNAEYKEK---------------ILTL--------------------------- 1009

  Fly  1071 RGPGRPPTGEILSATNATAHIELK-AQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAV 1134
                      |..:.:..|..::. |:.::||:.|     |.|....::.|..:.|..|::|:..
Yeast  1010 ----------IKESNSIAAQDDINLAKMSEEAQLK-----RKGGLITLKILFEVLGPSILQKLPQ 1059

  Fly  1135 FQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNE----LVSSMQLIETAAPHLHVALH-PQMFALL 1194
            .:.::|..:.....|...          .|.||    :|.|..::....|.:..:|. .::|...
Yeast  1060 LRSILFDSLSDHENEEAS----------KVDNEQGQKIVDSFGVLRALFPFMSDSLRSSEVFTRF 1114

  Fly  1195 PSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVV 1259
            |.|...:...|...|:.|||..|.||:|.:.:.|.:.:.::|||:.....|.:|||:.|.|..:.
Yeast  1115 PVLLTFLRSNLSVFRYSAARTFADLAKISSVEVMAYTIREILPLMNSAGSLSDRQGSTELIYHLS 1179

  Fly  1260 SRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDP--LQARKT 1322
            ..::..|:||::.|:|||||.|||.:|.||.|:|..||::::|:||:......|..|  |.|.:.
Yeast  1180 LSMETDVLPYVIFLIVPLLGRMSDSNEDVRNLATTTFASIIKLVPLEAGIADPKGLPEELVASRE 1244

  Fly  1323 RDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTIC 1387
            |:|:|:..:.:|.....:|:|:.|...||.|||.|:|||.|||||:|||||||||||||||||||
Yeast  1245 RERDFIQQMMDPSKAKPFKLPIAIKATLRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTIC 1309

  Fly  1388 ILAGDHM-----HRQTANLAN--LPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGRE 1445
            |:|.|..     :.:|.::.:  ||||:||||:|||||..|.:::   ...|:.:.|.|.|..|.
Yeast  1310 IIASDQYLRKEDYEKTRSVESRALPSLIICPPSLTGHWENEFDQY---APFLKVVVYAGGPTVRL 1371

  Fly  1446 KLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLIL 1510
            .||..: :..:::|.|||..|.|:...:...:|||||||||||||.::|.:||:|.:.|||||||
Yeast  1372 TLRPQL-SDADIIVTSYDVARNDLAVLNKTEYNYCVLDEGHIIKNSQSKLAKAVKEITANHRLIL 1435

  Fly  1511 SGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQV 1575
            :|||||||||||||||||||||||||||.|.:||::||.:||::|:|:|||||||||:||||:||
Yeast  1436 TGTPIQNNVLELWSLFDFLMPGFLGTEKMFQERFAKPIAASRNSKTSSKEQEAGVLALEALHKQV 1500

  Fly  1576 LPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLS 1640
            |||:|||:|||||.||||||.||..|||..||.:||.||:.|. |:.::|..::|      |...
Yeast  1501 LPFMLRRLKEDVLSDLPPKIIQDYYCELGDLQKQLYMDFTKKQ-KNVVEKDIENS------EIAD 1558

  Fly  1641 AKTHIFQALRYLQNVCNHPKLVLRQSE-ELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGI 1704
            .|.||||||:|::.:||||.|||..:. :|.:|...|..:...|.||.::.||.||:.||.:|||
Yeast  1559 GKQHIFQALQYMRKLCNHPALVLSPNHPQLAQVQDYLKQTGLDLHDIINAPKLSALRTLLFECGI 1623

  Fly  1705 GVQ--------------TESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQR 1755
            |.:              ...:||||||||||||.|||:||.||.::::|||||:|||||:....|
Yeast  1624 GEEDIDKKASQDQNFPIQNVISQHRALIFCQLKDMLDMVENDLFKKYMPSVTYMRLDGSIDPRDR 1688

  Fly  1756 QDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1820
            |.:|..||.|||||.|||||.||||||||||||||||||||||||.|||||||||||||||||||
Yeast  1689 QKVVRKFNEDPSIDCLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRIGQKKVVNV 1753

  Fly  1821 YRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLF-------------NGGKD 1872
            ||:||:.:||||||||||||:..|:|||:.:|:.|.:|.|.|:.|||             |.|..
Yeast  1754 YRIITKGTLEEKIMGLQKFKMNIASTVVNQQNSGLASMDTHQLLDLFDPDNVTSQDNEEKNNGDS 1818

  Fly  1873 KGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDLGNFVQALK 1922
            :.|:........|...|.:...:.| |.|||...||||||:|..|::.|:
Yeast  1819 QAAKGMEDIANETGLTGKAKEALGE-LKELWDPSQYEEEYNLDTFIKTLR 1867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_001287351.1 HEAT repeat 5..30 CDD:293787 14/24 (58%)
HEAT repeat 42..70 CDD:293787 12/27 (44%)
HEAT repeat 395..420 CDD:293787 18/24 (75%)
HEAT repeat 433..465 CDD:293787 13/39 (33%)
HEAT repeat 475..504 CDD:293787 11/28 (39%)
HEAT repeat 516..540 CDD:293787 9/25 (36%)
HEAT repeat 560..589 CDD:293787 16/28 (57%)
DUF3535 654..1138 CDD:288874 106/543 (20%)
HEAT repeat 1234..1261 CDD:293787 9/26 (35%)
HEAT repeat 1269..1298 CDD:293787 16/28 (57%)
SNF2_N 1353..1662 CDD:278600 182/315 (58%)
DEXDc 1370..1514 CDD:238005 74/150 (49%)
Helicase_C 1689..1813 CDD:278689 88/137 (64%)
MOT1NP_015243.1 HEAT repeat 360..385 CDD:293787 18/24 (75%)
HEAT repeat 406..438 CDD:293787 8/31 (26%)
HEAT repeat 449..481 CDD:293787 12/31 (39%)
HEAT repeat 490..519 CDD:293787 12/29 (41%)
HEAT repeat 543..572 CDD:293787 16/28 (57%)
DUF3535 611..1063 CDD:403318 106/543 (20%)
HepA 1011..1803 CDD:223627 393/817 (48%)
DEXHc_Mot1 1272..1507 CDD:350757 143/238 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157342212
Domainoid 1 1.000 337 1.000 Domainoid score I162
eggNOG 1 0.900 - - E1_KOG0392
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31978
Inparanoid 1 1.050 977 1.000 Inparanoid score I31
Isobase 1 0.950 - 0 Normalized mean entropy S1216
OMA 1 1.010 - - QHG55547
OrthoFinder 1 1.000 - - FOG0004898
OrthoInspector 1 1.000 - - oto99944
orthoMCL 1 0.900 - - OOG6_101665
Panther 1 1.100 - - LDO PTHR10799
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R735
SonicParanoid 1 1.000 - - X3453
TreeFam 1 0.960 - -
1615.740

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