DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hel89B and IRC5

DIOPT Version :10

Sequence 1:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_116696.2 Gene:IRC5 / 850599 SGDID:S000001934 Length:853 Species:Saccharomyces cerevisiae


Alignment Length:668 Identity:199/668 - (29%)
Similarity:302/668 - (45%) Gaps:134/668 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1320 RKTRDREFLDYL----FNPKSIPNYKVPVPISVE---------LRCYQQAGINWLWFLNKYNLHG 1371
            |||:.:...|:.    .|..:......|...:::         |:.||..|:|||..|.:..|:|
Yeast   179 RKTKKKSITDFFKKQKKNEDTTTQNGAPDDAAIKQPRLLKNCILKPYQLEGLNWLITLYENGLNG 243

  Fly  1372 ILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLH 1436
            ||.|:||||||:|:|.:||..: ...|..    |.||..|.:...:|:.|..||.....||:   
Yeast   244 ILADEMGLGKTVQSIALLAFIY-EMDTKG----PFLVTAPLSTLDNWMNEFAKFAPDLPVLK--- 300

  Fly  1437 YYGFPVGRE---KLRSDI----GTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTK 1494
            |||....:|   ||::..    ||  .:|:.||:.:.:|.|.....::.:.::||||.:||...:
Yeast   301 YYGTNGYKERSAKLKNFFKQHGGT--GIVITSYEIILRDTDLIMSQNWKFLIVDEGHRLKNINCR 363

  Fly  1495 SSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPIL-----SSRDA 1554
            ..|.:|::..::||:|:|||:|||:.|||||.:|:||......:.|.:.|....|     |:.:|
Yeast   364 LIKELKKINTSNRLLLTGTPLQNNLAELWSLLNFIMPDIFADFEIFNKWFDFDSLNLGSGSNSEA 428

  Fly  1555 KSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKD-LPPKITQDLLCELSPLQLRLYEDFSNKH 1618
            .:.....|.....:..||..:.||||||:|:.||.: ||||....:.|.::..|.:.|:...|..
Yeast   429 LNKLINDELQKNLISNLHTILKPFLLRRLKKVVLANILPPKREYIINCPMTSAQEKFYKAGLNGK 493

  Fly  1619 LKDCLDK-------------LGDSSSASM---VTENLSAKTHIFQALRYLQNVCNHPKLVLRQSE 1667
            ||..:.|             :|..|:.|:   :...||...        ..|..|.....|.|.:
Yeast   494 LKKTMFKELIKDFFTLNDEYIGHVSNRSIRDFINYKLSGNE--------TSNTDNKINPTLLQMD 550

  Fly  1668 ELTKVTSQLALSNSSLDD------------------------------IEHSAKLPALKQLLLDC 1702
            :|.|...|:.:||..|.:                              ::.|.||..|::|:   
Yeast   551 KLYKKNLQMEISNKKLQNMMMQLRQIIDSTFLFYFPYLHPEDLTLETLLKTSGKLQILQKLI--- 612

  Fly  1703 GIGVQTESVSQ-HRALIFCQLKAMLDIVEQ--DLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNS 1764
                 ...:|: |:.||:.|...|||::|.  |     |.|....|:||||....|:|.:..|||
Yeast   613 -----PPLISEGHKVLIYSQFVNMLDLIEDWCD-----LNSFATFRIDGSVNNETRKDQLEKFNS 667

  Fly  1765 D-PSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNS 1828
            . ...::.||:|...|||:||.|||||:..:.||||..|||||||.|||||:..|.||||...|:
Yeast   668 SKDKHNIFLLSTRAAGLGINLVGADTVVLFDSDWNPQVDLQAMDRCHRIGQESPVIVYRLCCDNT 732

  Fly  1829 LEE-------------------------KIMGLQKFKILTANTV-VSAENASL-QTMGTSQIFDL 1866
            :|.                         |.:.|.:...|.||.. |:..|..| |.:....:.|.
Yeast   733 IEHVILTRAANKRNLERMVIQMGKFNNLKKLALNEGSFLKANKAGVNVTNKDLVQELSMLLMSDE 797

  Fly  1867 FNGGKDKGAESGSSAVQG 1884
            .|.|.:.|.:..:.|.:|
Yeast   798 SNIGFENGGQKENKATEG 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:463447
HepA <1342..1849 CDD:440319 184/604 (30%)
IRC5NP_116696.2 PLN03142 74..>767 CDD:215601 186/618 (30%)
Blue background indicates that the domain is not in the aligned region.

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