Protein Alignment Hel89B and BRM

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_973695.1
• Gene: BRM / 819210
• AraportID: AT2G46020
• Length: 2193
• Species: Arabidopsis thaliana
• Alignment Length: 1985
• Identity: 417/1985 - (21%)
• Similarity: 675/1985 - (34%)
• Gaps: 660/1985 - (33%)

  Fly    89 ATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILHKGARLIGSEGNEFDVQEEQPAS 153
            |..||:.::||...|..||                                      ||::|...
plant    19 AGRTASTSSAASPSSSSSS--------------------------------------VQQQQQQQ 45

  Fly   154 GGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDEDVALNRSGSTYNV----NAEKL 214
            ...::.:.||||..:|:...:|                  |:|::...:.|....:    |....
plant    46 QQQQQQQQLASRQQQQQHRNSD------------------TNENMFAYQPGGVQGMMGGGNFASS 92

  Fly   215 PVEHLLNIKTAANGSGQAPLSCREMNRAKRKARQNTSGCSVTAVTPTCSRRNSN----------- 268
            |            ||.|.|...|....:.::.:|.....|.|..    .::|.|
plant    93 P------------GSMQMPQQSRNFFESPQQQQQQQQQGSSTQE----GQQNFNPMQQAYIQFAM 141

  Fly   269 -SNHSTGSNHSSNGTTG-AAIEEPEKKKLKSTDRQEIFYSLN-AAVPDATGTWVDAVSWPLENFC 330
             :.|......:..|..| :::.:.:..::...:.|:    || ::.|.|:.
plant   142 QAQHQKAQQQARMGMVGSSSVGKDQDARMGMLNMQD----LNPSSQPQASS-------------- 188

  Fly   331 SRLFIDLFHAKWEVRHGAATALRELINQHAQ---GAGKAVLQTREQMDEAHSRWLEDAALRLLCV 392
            |:...|.| |:.|.:..:::..|.....|.|   |.|:
plant   189 SKPSGDQF-ARGERQTESSSQQRNETKSHPQQQVGTGQ--------------------------- 225

  Fly   393 LCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVN-------ILLQLIQHKNEWDVR 450
                          :.|         |.:::.|:|.:.|::||       ...|..|....|
plant   226 --------------LMP---------GNMIRPMQAPQAQQLVNNMGNNQLAFAQQWQAMQAW--- 264

  Fly   451 HGGLLGLKYVFVVREELLPIYLPQSIS---NILIGLLDAVDDVG---AVAAATLIPVSSWLPKLL 509
                        .||..:.:..|.:.|   :||...:.|....|   ..:.:..||:||
plant   265 ------------ARERNIDLSHPANASQMAHILQARMAAQQKAGEGNVASQSPSIPISS------ 311

  Fly   510 NPAQVSSIVKMLWDLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPRLWPFLSHS 574
            .||. ||:|         ..|.:...||...:                             ...|
plant   312 QPAS-SSVV---------PGENSPHANSASDI-----------------------------SGQS 337

  Fly   575 TSSVRRSTLKT-LMTLTSADRVKSEPKD--ENQVKEEADKEEMKLNFGVSDWKWELLQQALRHIY 636
            .|:..|..|.| ....||:.|:.:...:  ..|.:|..                         :|
plant   338 GSAKARHALSTGSFASTSSPRMVNPAMNPFSGQGRENP-------------------------MY 377

  Fly   637 QRILVEPQ------ADIQALARQ---VWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFDA 692
            .|.||:|.      ..:|..|.:   :..|......||...|           |.||.||
plant   378 PRHLVQPTNGMPSGNPLQTSANETPVLDQNASTKKSLGPAEH-----------LQMQQPR----- 426

  Fly   693 GVLIRAGGDVSTPGSTSRKRTPRIGDELGGNILAQ------SNASLKLYLGGSEA---TPLDVRD 748
                    .::||       ||        |::|.      ||:||:...|..:|   :....:.
plant   427 --------QLNTP-------TP--------NLVAPSDTGPLSNSSLQSGQGTQQAQQRSGFTKQQ 468

  Fly   749 ANFMRARISSSRAL----GALSHYLVQ---PAPGVVYTPQTESPTDCYTKVLLGHLNAHSA---- 802
            .:.::|:|.:.|.|    |:|...|:|   |.|..:.|.:..||.       :|.:...|:
plant   469 LHVLKAQILAFRRLKKGEGSLPPELLQAISPPPLELQTQRQISPA-------IGKVQDRSSDKTG 526

  Fly   803 ---VQRIVCGLIIAFWALEDEPV------RPGPPNL-----QEKLHQCVSEYVYYDEVAISLTRL 853
               .:.:.||......|..:.|:      ..|...:     ..:|.|.:.:.....:||   |:.
plant   527 EDQARSLECGKESQAAASSNGPIFSKEEDNVGDTEVALTTGHSQLFQNLGKEATSTDVA---TKE 588

  Fly   854 LQEAQDFIATLKQNKIPINDFNNAKILTLDQIEAVATTLSEN----LRSYPLKPKVLDMLEERR- 913
            .|:...|.....|........|.....|.|:.:|||:..|::    ..:.|..||  |....|:
plant   589 EQQTDVFPVKSDQGADSSTQKNPRSDSTADKGKAVASDGSQSKVPPQANSPQPPK--DTASARKY 651

  Fly   914 -----------RSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQ 967
                       |.|. ||...|:     :.:....||..|..|.|
plant   652 YGPLFDFPFFTRKLD-SYGSATA-----NANNNLTLAYDIKDLIC-------------------- 690

  Fly   968 CLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPLETLK--------Q 1024
                 :..||||        .:..:.:.|.:|.|...........|.||:.|:..:        |
plant   691 -----EEGAEFL--------SKKRTDSLKKINGLLAKNLERKRIRPDLVLRLQIEEKKLRLSDLQ 742

  Fly  1025 TPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRP------------- 1076
            :.|..||...           ||.:.:.                    |.||
plant   743 SRVREEVDRQ-----------QQEIMSM--------------------PDRPYRKFVRLCERQRL 776

  Fly  1077 -PTGEILSATNATAHIELKA-----QQAKEA-----EAKQCRIQRLGAACAIEKLCRIFGEQIIE 1130
             ...::|:...|....:||.     ::..||     :|:..|  ..|.|...||:.|.|.::..:
plant   777 EMNRQVLANQKAVREKQLKTIFQWRKKLLEAHWAIRDARTAR--NRGVAKYHEKMLREFSKRKDD 839

  Fly  1131 -KVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALHPQMFALL 1194
             :....:.|....||::.:...:.:..  :|........|.|..|.:| ..:||
plant   840 GRNKRMEALKNNDVERYREMLLEQQTN--MPGDAAERYAVLSSFLTQT-EDYLH----------- 890

  Fly  1195 PSLGFIVCHPLKAVRHM-----AARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEA 1254
             .||    ..:.|.::.     ||...||.|.                |.|..|:.: |..|..|
plant   891 -KLG----GKITATKNQQEVEEAANAAAVAAR----------------LQGLSEEEV-RAAATCA 933

  Fly  1255 IERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDP--L 1317
            .|.||.|.:..              .|:.|.|:..:...:..|:.|        .|.:...|  |
plant   934 REEVVIRNRFT--------------EMNAPKENSSVNKYYTLAHAV--------NEVVVRQPSML 976

  Fly  1318 QARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKT 1382
            ||...||                            ||..|:.|:..|....|:|||.|:||||||
plant   977 QAGTLRD----------------------------YQLVGLQWMLSLYNNKLNGILADEMGLGKT 1013

  Fly  1383 LQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKL 1447
            :|.:.::|  ::.....|..  |.|:|.|..:..:|..|:..:|...|.   ::|.|....|.||
plant  1014 VQVMALIA--YLMEFKGNYG--PHLIIVPNAVLVNWKSELHTWLPSVSC---IYYVGTKDQRSKL 1071

  Fly  1448 RSD--IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLIL 1510
            .|.  ...|.|::|.:|:.:..|....|.:.:.|.::||...:|:.::..::.:.|.:...||:|
plant  1072 FSQEVCAMKFNVLVTTYEFIMYDRSKLSKVDWKYIIIDEAQRMKDRESVLARDLDRYRCQRRLLL 1136

  Fly  1511 SGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILS---SRDAKSSAKEQEAGVLAMEALH 1572
            :|||:||::.|||||.:.|:|......|.|...|::|...   :.:.:....|.|..|:.:..||
plant  1137 TGTPLQNDLKELWSLLNLLLPDVFDNRKAFHDWFAQPFQKEGPAHNIEDDWLETEKKVIVIHRLH 1201

  Fly  1573 RQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTE 1637
            :.:.||:|||..|||...||.|::..|.|.:|.:|..:|         |.:...| :.......|
plant  1202 QILEPFMLRRRVEDVEGSLPAKVSVVLRCRMSAIQSAVY---------DWIKATG-TLRVDPDDE 1256

  Fly  1638 NLSA-KTHIFQALRY---------LQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHS-AK 1691
            .|.| |..|:||..|         |:..||||.|......:.:|            |.:..| .|
plant  1257 KLRAQKNPIYQAKIYRTLNNRCMELRKACNHPLLNYPYFNDFSK------------DFLVRSCGK 1309

  Fly  1692 LPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQ 1756
            |..|.::|    |.:|.   :.||.|:|..:..:|||:|:.|..|.|   .|.|:||:.....|:
plant  1310 LWILDRIL----IKLQR---TGHRVLLFSTMTKLLDILEEYLQWRRL---VYRRIDGTTSLEDRE 1364

  Fly  1757 DIVNNFNSDPSID--VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVN 1819
            ..:.:|| ||..|  :.||:....|.||||..||||:..:.|.||..:.||:.|||||||.:.|.
plant  1365 SAIVDFN-DPDTDCFIFLLSIRAAGRGLNLQTADTVVIYDPDPNPKNEEQAVARAHRIGQTREVK 1428

  Fly  1820 VYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQG 1884
            |   |...::.||:...||...|.:...|..|:            |:  .|||:...|    ::|
plant  1429 V---IYMEAVVEKLSSHQKEDELRSGGSVDLED------------DM--AGKDRYIGS----IEG 1472

  Fly  1885 TASGGMSMNTIIENLPELWSEHQYEEEYDLGNFVQ 1919
                      :|.|..:.:.....:|..:.|.|.|
plant  1473 ----------LIRNNIQQYKIDMADEVINAGRFDQ 1497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787	1/24 (4%)
		HEAT repeat	433..465	CDD:293787	5/38 (13%)
		HEAT repeat	475..504	CDD:293787	8/34 (24%)
		HEAT repeat	516..540	CDD:293787	5/23 (22%)
		HEAT repeat	560..589	CDD:293787	5/29 (17%)
		DUF3535	654..1138	CDD:463447	105/566 (19%)
		HepA	<1342..1849	CDD:440319	161/524 (31%)
BRM	NP_973695.1	QLQ	462..497	CDD:214931	8/34 (24%)
		PLN03142	831..>1438	CDD:215601	198/735 (27%)
		DEXHc_SMARCA2_SMARCA4	978..1213	CDD:350754	76/269 (28%)
		BROMO	1900..2004	CDD:197636