DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and ASG3

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_973689.2	Gene:	ASG3 / 819106	AraportID:	AT2G44980	Length:	877	Species:	Arabidopsis thaliana

Alignment Length:	624	Identity:	189/624 - (30%)
Similarity:	289/624 - (46%)	Gaps:	111/624 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1346 ISVELRCYQQAGINWLWFLNKYNLHGI----LCDDMGLGKTLQTICILAGDHMHRQTANLANLPS 1406
            ::..|:.:|..|::||  :.|| |.|:    ..|.||||||||.|..|:.....:....    |.
plant    47 VTATLKPHQVEGVSWL--IQKY-LLGVNVVLELDQMGLGKTLQAISFLSYLKFRQGLPG----PF 104

  Fly  1407 LVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDI------GTK-----CNLVVA 1460
            ||:||.::|..||.|:.:|.....|||   |.|....|..:|..:      .:|     .::::.
plant   105 LVLCPLSVTDGWVSEINRFTPNLEVLR---YVGDKYCRLDMRKSMYDHVKKSSKGHFLPFDVLLT 166

  Fly  1461 SYDTVRKDIDFFSGIHFNYCVLDEGHIIKN-GKTKSSKAIKRLKANHRLILSGTPIQNNVLELWS 1524
            :||....|.||.|.|.:.|.::||...:|| .....:..:::.....||:::|||||||:.|||:
plant   167 TYDIALVDQDFLSQIPWQYAIIDEAQRLKNPNSVLYNVLLEQFLIPRRLLITGTPIQNNLTELWA 231

  Fly  1525 LFDFLMPGFLGTEKQFVQRFSR--PILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDV 1587
            |..|.||...||..||:..|..  ..||..|..:..:..::....:.|       |:|||.|..:
plant   232 LMHFCMPLVFGTLDQFLSAFKETGDGLSGLDVSNDKETYKSLKFILGA-------FMLRRTKSLL 289

  Fly  1588 LKD----LPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLD-KLGDSSSASMVTENLSAKTHIFQ 1647
            ::.    |||.....::..|..||.::|.....|.|...|: ..|.|:..|:  :|:     :.|
plant   290 IESGNLVLPPLTELTVMVPLVSLQKKIYTSILRKELPGLLELSSGGSNHTSL--QNI-----VIQ 347

  Fly  1648 ALRYLQNVCNHPKLV-------LRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLL---DC 1702
                |:..|:||.|.       ..:.|.|                ::.|.||..|.|||.   |.
plant   348 ----LRKACSHPYLFPGIEPEPFEEGEHL----------------VQASGKLLVLDQLLKRLHDS 392

  Fly  1703 GIGVQTESVSQHRALIFCQLKAMLDIVEQDL-LRRHLPSVTYLRLDGSVPASQRQDIVNNFNS-- 1764
            |          ||.|:|.|:.:.|||::..: |||:    :|.||||||.|.:|...:.||::
plant   393 G----------HRVLLFSQMTSTLDILQDFMELRRY----SYERLDGSVRAEERFAAIKNFSAKT 443

  Fly  1765 ----DPSID-----VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1820
                |..:|     |.:::|..||:||||..||||||.|.||||..|.||:.|||||||...|..
plant   444 ERGLDSEVDGSNAFVFMISTRAGGVGLNLVAADTVIFYEQDWNPQVDKQALQRAHRIGQISHVLS 508

  Fly  1821 YRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMG---TSQIFDL--FNGGKDKGAESGSS 1880
            ..|:|.:|:||.|:...:.|:..::.||.......:..|   .|.:|.|  |:..:....||.:.
plant   509 INLVTEHSVEEVILRRAERKLQLSHNVVGDNMEEKEEDGGDLRSLVFGLQRFDPEEIHNEESDNL 573

  Fly  1881 AVQGTASGGMSMNTIIENLPELWSEHQYE---EEYDLGN 1916
            .:...:|....:..|.:|:.....|.::|   .:..|||
plant   574 KMVEISSLAEKVVAIRQNVEPDKEERRFEINSSDTLLGN 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	98/331 (30%)
		DEXDc	1370..1514	CDD:238005	45/159 (28%)
		Helicase_C	1689..1813	CDD:278689	59/138 (43%)
ASG3	NP_973689.2	PLN03142	38..>584	CDD:215601	182/594 (31%)
ASG3	NP_973689.2	Macro_Poa1p_like_SNF2	705..864	CDD:239447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920