Protein Alignment Hel89B and Rad54l2

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_109655.2
• Gene: Rad54l2 / 81000
• MGIID: 1933196
• Length: 1467
• Species: Mus musculus
• Alignment Length: 1066
• Identity: 244/1066 - (22%)
• Similarity: 403/1066 - (37%)
• Gaps: 286/1066 - (26%)

  Fly  1007 SDPEFTPKLVM---PLETLKQTPVSSEVINNCVYYGIL-TLALQQTVTTTNTRSGAGGATTPTAT 1067
            |||:..|.:.:   ..|..::..|:.|..:.....|:| ..:|:....|.:.:.|..|...|..|
Mouse     9 SDPDLDPDVELEDEEEEEEEEEEVAVEEHDRDDEEGLLDDTSLEGMCGTEHAQLGEDGQRPPRCT 73

  Fly  1068 TAPRGPGRPP-----TGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQ 1127
            :.......|.     .|:||::.:.      |.::|::....:..|::|.....:|.:.:...::
Mouse    74 STTSSQSEPSEQLRHQGKILASEDP------KKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQE 132

  Fly  1128 IIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALH--PQM 1190
            .:|:..        ::||                           |..|.|||...|.|.  |:.
Mouse   133 ELERRK--------RLEQ---------------------------QRKEYAAPIPTVPLEFLPEE 162

  Fly  1191 FALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI 1255
            ..|..|.|     |....|.:|...|.    :|:..             |..::...|...||..
Mouse   163 IVLRASDG-----PQLPPRVLAQEVIC----LDSSS-------------GSEDEKSSRDEVIELS 205

  Fly  1256 ERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQAR 1320
            ......|.|          |....::|:.||......||.                  :|.|...
Mouse   206 SGEEDTLHI----------VDSSESVSEEDEEEEKGGTHV------------------NDALNQH 242

  Fly  1321 KTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLW---------FLNKYNLHGILCDD 1376
            ....|..:: |.:|....|..:...::..::.:|..||.:|:         |........||...
Mouse   243 DALGRVLVN-LNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHS 306

  Fly  1377 MGLGKTLQTICILAGDHMHRQTANLANLPS---LVICPPTLTGHWVYEVEKFLDQGSVL------ 1432
            ||||||||.|..:  |.:.|.|      |:   |.|.|.....:|:.|...:|.....|
Mouse   307 MGLGKTLQVISFI--DVLFRHT------PAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKP 363

  Fly  1433 ---RPLHY--------YGFPVGREKLRSDIGTKCNLVVASYD-----TVRK-------------- 1467
               :|..:        :.....|.|:.:|..::..:::..|:     |::|
Mouse   364 EEVQPRFFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSLATSRPKKTKKRS 428

  Fly  1468 -----DID-------FFSGIHFNYC-------VLDEGHIIKNGKTKSSKAIKRLKANHRLILSGT 1513
                 |:|       |........|       :.||||.|||.:..:|:|:|.:::..|::|:|.
Mouse   429 HPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGY 493

  Fly  1514 PIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPF 1578
            |:|||::|.|.:.||:.|.||||.::|...|.||||:.:...|:.::..........||..:..|
Mouse   494 PLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGF 558

  Fly  1579 LLRRVKEDVLK-DLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAK 1642
            :.|| ...||| .||.|....:|..||.:|..||..|.:: .:||    |.|.
Mouse   559 VQRR-GHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDR-FRDC----GTSG------------ 605

  Fly  1643 THIFQALRYLQNVC------NHPKLVLR--QSEEL------------------------TKVTSQ 1675
               :..|..|:..|      |||.::..  |.|.|                        |||..:
Mouse   606 ---WLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSARCPPHGTKVKGE 667

  Fly  1676 LALSNSSLDDIEHSAKLPAL------------------KQLLLDCGIGVQTESVSQ--------- 1713
            .:...||:.:..:|..|..:                  |:||.:...||...|...
Mouse   668 DSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKELLTNYQTGVLENSPKMVLLFHLIEE 732

  Fly  1714 -----HRALIFCQLKAMLDIVEQDLLRRHLP---------------SVTYLRLDGSVPASQRQDI 1758
                 .:.|:|.|..:.|.::|:.|.:|.:|               :|:|.|||||.||.:|:.:
Mouse   733 SVKLGDKILVFSQSLSTLALIEEFLGKRDMPCLPGAEGQGTQKWVRNVSYFRLDGSTPAFERERL 797

  Fly  1759 VNNFNSDPS---IDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1820
            :|.|| |||   ..:.||:|..|.||:||.||:.|:..:..|||..|.||:.|.:|.||||..::
Mouse   798 INQFN-DPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHI 861

  Fly  1821 YRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGT 1885
            |||:...:||:||...|..|...::.||...|..| .....::.:|.:..:.:.|...|..::|.
Mouse   862 YRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPML-NFTRKEVENLLHFVEKEPAPQTSLDIKGI 925

  Fly  1886 ASGGMSMNTIIENLPELWSEHQYEEE 1911
            ....:.:..:  ..|.|.::..:|.|
Mouse   926 KESVLQLACL--KYPHLITKEPFEHE 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	25/139 (18%)
		HepA	<1342..1849	CDD:440319	172/656 (26%)
Rad54l2	NP_109655.2	HepA	110..890	CDD:440319	212/895 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..236		13/90 (14%)
		DEXHc_ARIP4	271..547	CDD:350827	71/283 (25%)
		DEAH box	463..466		2/2 (100%)
		LXXLL motif 1	551..555		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..671		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1046
		PHA03247	<1112..1445	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1171
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1213
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1282
		LXXLL motif 2	1329..1333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1445..1467