Protein Alignment Hel89B and smarcal1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001072923.1
• Gene: smarcal1 / 780385
• XenbaseID: XB-GENE-493391
• Length: 942
• Species: Xenopus tropicalis
• Alignment Length: 928
• Identity: 218/928 - (23%)
• Similarity: 359/928 - (38%)
• Gaps: 249/928 - (26%)

  Fly  1050 TTTNTR-SGAGGATTPTA----TTAPRGPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQ 1109
            |||.|: .|||..:.|..    .|...|..|..||   ||..|     :.|::|..|...:|
 Frog   183 TTTITKFYGAGPGSKPAVPVSNKTVSEGRERGVTG---SAAEA-----VPAKKASGATRGRC--- 236

  Fly  1110 RLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYD-----WRLGSLLPDLGVCNELV 1169
                ....|...|:......|.:|:|:.:        ..:.||     |..|  |.|.......|
 Frog   237 ----VKHAESRFRVEVGYSAELIALFKTI--------PSKNYDPATKMWNFG--LEDYASLMSEV 287

  Fly  1170 SSMQLIETAAPHLHVALHPQMFALLPSLG--------FIVCH----PLKAVRHMAARCIAVLAEI 1222
            ..:|.:|..|..   .:.....|..|:.|        ..:|:    |...:|   .|||.|..
 Frog   288 QQLQSVELKALE---GMEGVQIAPPPATGGGTNINALLAMCNNWQRPSATLR---GRCILVSR-- 344

  Fly  1223 DACQTMQFVVHDLLPLLGKIEQLIER----------------QGAIEAIERVVSRLQIKVVPYIV 1271
             :...|:...|  ..::|..:|:..|                |..:|::..:   .|::|.|
 Frog   345 -SRFEMEIGYH--AEIIGLFKQMNTRNYDTKTRKWSFMLEDYQKLMESVRNI---QQVEVEP--- 400

  Fly  1272 LLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKS 1336
             |..|:|.|.:                     |..|||..::.:
 Frog   401 -LPRPVLQAFA---------------------PQFGKTTIIREE--------------------- 422

  Fly  1337 IPNY---KVPVPISVELRCYQQAGINWLWFLNKYNLHG--ILCDDMGLGKTLQTICILAGDHMHR 1396
            ||..   :|...:...|..:|:.|:|:     ..:..|  :|.||||||||:|.|||.|   .:|
 Frog   423 IPEVDLSQVDSKLGSNLMPFQRDGVNF-----AVSREGRLLLADDMGLGKTIQAICIAA---YYR 479

  Fly  1397 QTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVAS 1461
            :     ..|.||:.|.::...|....:::|..   :||........||:   |...:..|:|  |
 Frog   480 K-----EWPLLVVAPSSVRFTWAEAFQRWLPS---IRPESVNVIVTGRD---SQSASLINIV--S 531

  Fly  1462 YDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRL--KANHRLILSGTPIQNNVLELWS 1524
            :|.:.| :|......|...::||.|.:||.||...||...|  .|...::|||||..:...||::
 Frog   532 FDLLGK-MDKQIAATFQVIIIDESHFLKNVKTARCKAAMPLLKSAKRVMLLSGTPAMSRPAELYT 595

  Fly  1525 LFDFLMPGFLGTEKQFVQRF--SRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDV 1587
            ....:.|.|......|..|:  ::.:....|...|:...|..:|..|::       ::||:|.:|
 Frog   596 QIAAVRPSFFPRFHDFGIRYCDAKQMPWGWDYSGSSNLNELKLLLEESI-------MIRRLKSEV 653

  Fly  1588 LKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYL 1652
            |..||.|  |..:..::|      |..:.|      .|...:::|..:.:...:|....:||...
 Frog   654 LSQLPAK--QRKMVVVAP------EGITAK------TKAALAAAAKEMAKGFKSKVQEKEALLLF 704

  Fly  1653 QNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRAL 1717
            .|         |.:|                      ||:.::.:.::|.     .|| .:.:.|
 Frog   705 YN---------RTAE----------------------AKIRSVLEYIMDL-----LES-GREKFL 732

  Fly  1718 IFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGL 1782
            :|...|.:||.:.::|.::.:|   |:|:||:..::.||.:.:.|.......|.:|:.....:||
 Frog   733 VFAHHKLVLDHICEELGKKDVP---YIRIDGNTSSADRQSLCHKFQMSEKSCVAVLSITAANMGL 794

  Fly  1783 NLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKI--MGLQKFKILTAN 1845
            .|:.||.|:|.|..|||...:||.||.|||||...||::.|:.:.:.::.:  |..:|.|:| ..
 Frog   795 TLSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVNIHYLVAKGTADDYLWPMIQEKIKVL-GQ 858

  Fly  1846 TVVSAENASLQTMGT---------SQIFDLFNGG-KDKGAESGSSAVQGTASGGMSMNTIIENLP 1900
            ..:|..|.|..|..|         ..|:|||... .::|||:.:...           .::|..
 Frog   859 AGLSEANFSETTESTDYFYKDPKQKTIYDLFQRSFSEEGAETNADEA-----------LLLEAC- 911

  Fly  1901 ELWSEHQYEEEYDLGNFV 1918
                     ||.|||:.|
 Frog   912 ---------EEADLGDAV 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	25/92 (27%)
		HepA	<1342..1849	CDD:440319	134/514 (26%)
smarcal1	NP_001072923.1	PTZ00436	<7..205	CDD:185616	8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..214		10/30 (33%)
		HARP	244..298	CDD:462166	13/63 (21%)
		HARP	347..401	CDD:462166	10/62 (16%)
		DEXHc_HARP_SMARCAL1	439..648	CDD:350768	65/237 (27%)
		DESH box	552..555		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	647..664		9/18 (50%)
		SF2_C_SNF	711..836	CDD:350180	43/133 (32%)