Protein Alignment Hel89B and Ttf2

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_036019252.1
• Gene: Ttf2 / 74044
• MGIID: 1921294
• Length: 1155
• Species: Mus musculus
• Alignment Length: 1290
• Identity: 279/1290 - (21%)
• Similarity: 456/1290 - (35%)
• Gaps: 399/1290 - (30%)

  Fly   822 VRPGPPNLQEKLHQCVSE---YVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLD 883
            ||.| ||..:..:.|.:.   :|...::.:|...|.:|   |:..|:...:|.:...........
Mouse    19 VRDG-PNKGKSFYVCRTNTCGFVQATDIPVSHCLLHEE---FVVELQGLFLPQDKKEWRLFFRCA 79

  Fly   884 QIEAVATTLSENL--RSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALH 946
            :.:|.......|:  |..| .||.|        |:.:..||.:..|                 ||
Mouse    80 RTKAEGKQWCGNVPWRQDP-NPKEL--------SVTSKPQQPSESQ-----------------LH 118

  Fly   947 CLPDKLNP--VVKPLMESIKREQCLQ----------LQQLSAEFLVHLMDQVCDRNPSPNSKILN 999
            ......||  |:....::::|:|.::          |::.:.:    |:||..::.|..||:
Mouse   119 SPSQPRNPFRVLNKNQKTLERKQFVEEGERKTADKKLRENNEQ----LLDQRKEQKPKSNSR--- 176

  Fly  1000 NLCTLLRSDP--------------------EFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLA 1044
                 :..||                    :|.||      |.|...::|:..:..|..||   .
Mouse   177 -----MEKDPSSDLVATRQSGGDREEQEKSKFQPK------TKKAEGMASKQGHGEVLQGI---P 227

  Fly  1045 LQQTVTTTNTRSGAGGATT----PTATTAPRGPGRPPTGEILSATNATAHIELKAQQAKEAEAKQ 1105
            ....::.:.:|.......|    .|....|..||:.|..::    ....|:  ..:..|..||..
Mouse   228 KGPHMSESESRGVPNKPETLREKETQLLVPSVPGQNPESKV----QKEGHV--SREPLKNGEAPS 286

  Fly  1106 CRIQRLG-----------------AACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDW 1153
            .::.:.|                 .|.|..:||           :...|......|....:....
Mouse   287 AQVTQRGLAQGPLQGPSKTWRPVPEAPAAPELC-----------SGMAHHATSSSEDSEDDGVSS 340

  Fly  1154 RLGS-LLPDLGVCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIA 1217
            |.|| ||.|..|.::...|:|                             |..::|:........
Mouse   341 RPGSPLLFDSTVDSQKKGSLQ-----------------------------HSDQSVQRQMPAASG 376

  Fly  1218 VLAEID----ACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI---------ERVVSRLQIKVVPY 1269
            |..:.|    |.|......           ||.:::|.:.|:         |:::.::|......
Mouse   377 VSKKGDSSDPAAQRANLTT-----------QLKQKKGTLAAVNIQALPDKGEKLLKQIQALEDAL 430

  Fly  1270 IVLLVVPLLG-----AMSDPDESVRLLSTHCFANLVQLMPLD--------------GKTEQ---- 1311
            ..|.:.|..|     :..:|::|....:.....:||...||.              |:.|.
Mouse   431 SALALSPEQGTKEKCSAQEPEQSNITKAAAAPLHLVPPQPLPRPLIQPASSLGLKAGRQETPEGA 495

  Fly  1312 -------------LKSDPLQARKTRDR-----------EFLDYLFNP-KSIPNYKV----PVPIS 1347
                         :....|||....::           |.:|.|... ||.|....    |..:.
Mouse   496 SQCSGEGWPGTCCMDQVGLQALGHMNQHHLYNVWKITSEAIDELHRSLKSCPGETAVAEDPAGLK 560

  Fly  1348 VELRCYQQAGINW-LWFLNKYNLHGILCDDMGLGKTLQTIC-ILAGDHMHRQTANLANLP----- 1405
            |.|..:|:..:.| ||..::....|||.|||||||||..|. ||...:..:......:.|
Mouse   561 VPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTKKNQQKSKEKERSEPVTWLS 625

  Fly  1406 -----------SLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVV 1459
                       :|::||.:|..||..||||.:.... ||...|:|  ..|.:....:.| .::|:
Mouse   626 KNDSSVFTSSGTLIVCPASLIHHWKNEVEKRVTSNR-LRIYLYHG--PNRSRHAKVLST-YDIVI 686

  Fly  1460 ASYDTVRKDIDF------FSGIHFNY--------------CVLDEGHIIKNGKTKSSKAIKRLKA 1504
            .:|..:.|:|..      ..|.:.:.              .:|||.|.:||.:.::|.|:.:|:|
Mouse   687 TTYSLLAKEIPTTKQEGEVPGANLSVEGTSAPLLQVVWARIILDEAHNVKNPRVQTSIAVCKLQA 751

  Fly  1505 NHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQ--EAGVLA 1567
            ..|..::|||||||:|:::||..||.                  .|..|..|..|.|  ...:..
Mouse   752 QARWAVTGTPIQNNLLDMYSLMKFLR------------------CSPFDEFSLWKSQVDNGSMKG 798

  Fly  1568 MEALHRQVLPFLLRRVKEDV------LKDLPPKITQDLLCELSPLQL------------------ 1608
            .|.|.......||||.|:.:      |..||.:     .|:|..|:|
Mouse   799 GERLSILTKSLLLRRTKDQLDSTGKPLVALPAR-----RCQLHRLKLSEDERAVYDIFLARSRSA 858

  Fly  1609 ------------------------RLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQAL 1649
                                    |:.::|.:...:.|  ...||...|.|        |:...|
Mouse   859 LQSYLKRQEGRGSHHGRSPDNPFSRVAQEFGSSVSQGC--PAADSQRPSTV--------HVLSQL 913

  Fly  1650 RYLQNVCNH---------------PKLVLRQSEELTKVT-SQLALSNSS--------------LD 1684
            ..|:..|.|               ..|||...|:|:.:| |::.:|..|              .|
Mouse   914 LRLRQCCCHLSLLKSALDPTELESEGLVLSLEEQLSALTLSKVDVSEPSPTVSLNGTCFKAELFD 978

  Fly  1685 DIEHSAKLPALKQLL--LDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLD 1747
            |...|.|:.:|...|  :..|.|.|       :::|..|..:||.:|...|.:..|   ||..:|
Mouse   979 DTRRSTKVSSLLAELEAIQKGPGSQ-------KSVIVSQWTSMLQVVALHLKKNRL---TYATID 1033

  Fly  1748 GSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRI 1812
            |||...||.|:|..||......|:|::.:.||:||||||.:.:..::..|||..:.||.||.:|:
Mouse  1034 GSVNPKQRMDLVEAFNHSQGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRV 1098

  Fly  1813 GQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLF 1867
            ||||.|.::|.:...::||||:.||:.|...|..|:|.....:..:..:.:..||
Mouse  1099 GQKKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSEGPVTKLTLADLKILF 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	65/373 (17%)
		HepA	<1342..1849	CDD:440319	168/630 (27%)
Ttf2	XP_036019252.1	zf-GRF	4..44	CDD:480736	7/25 (28%)
		HepA	<550..1135	CDD:440319	168/631 (27%)
		DEXHc_TTF2	563..813	CDD:350830	74/271 (27%)