Protein Alignment Hel89B and Chd5

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_017449128.1
• Gene: Chd5 / 691589
• RGDID: 1582725
• Length: 2000
• Species: Rattus norvegicus
• Alignment Length: 720
• Identity: 201/720 - (27%)
• Similarity: 325/720 - (45%)
• Gaps: 126/720 - (17%)

  Fly  1237 PLLGKIEQLIERQGAIE---AIERVVSR-----------LQIKVVPY------IVLLVVPLLGAM 1281
            ||..|:|:...|.|...   .:.|:::.           ::.|.:||      |..:.:|....:
  Rat   571 PLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEIDEIDIPYYDNL 635

  Fly  1282 SDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKV-PVP 1345
            .......|.|.....|.|.:.:...||  :||.|  :..|..|...:|        |..|. ..|
  Rat   636 KQTYWGHRELMLGEDARLPKRLVKKGK--KLKDD--KQEKPPDTPIVD--------PTVKFDKQP 688

  Fly  1346 ISVE-----LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLP 1405
            ..::     |..||..|:|||.|........||.|:||||||:|||..|...:....:..    |
  Rat   689 WYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKG----P 749

  Fly  1406 SLVICPPTLTGHWVYEVEKFL------------DQGSVLRPLHYYGFP-----VGRE--KLRSDI 1451
            .||..|.:...:|..|.|.:.            :..||:|. :.:.|.     .|::  :::.::
  Rat   750 YLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRE-NEFSFEDNAIRGGKKVFRMKKEV 813

  Fly  1452 GTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQ 1516
            ..|.::::.||:.:..|......|.:...|:||.|.:||.::|..:.:...|.:::|:|:|||:|
  Rat   814 QIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQ 878

  Fly  1517 NNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLR 1581
            ||:.||:.|.:||.|......:.|::.|:          ..:||.:     ::.||..:.|.:||
  Rat   879 NNLEELFHLLNFLTPERFNNLEGFLEEFA----------DISKEDQ-----IKKLHDLLGPHMLR 928

  Fly  1582 RVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIF 1646
            |:|.||.|::|.|....:..|||.:|.:.|:....::. :.|:..|..:..|::
  Rat   929 RLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNF-EALNSKGGGNQVSLL----------- 981

  Fly  1647 QALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDD---IEHSAKLPALKQLLLDCGIGVQT 1708
            ..:..|:..||||.|.     .:..|.:.: |.|.|.|.   ::.|.||..|:::|..    ::.
  Rat   982 NIMMDLKKCCNHPYLF-----PVAAVEAPM-LPNGSYDGSSLVKSSGKLMLLQKMLKK----LRD 1036

  Fly  1709 ESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VL 1771
            |.   ||.|||.|:..|||::|..|   ......|.|:||.:....||:.::.||: |...  ..
  Rat  1037 EG---HRVLIFSQMTKMLDLLEDFL---EYEGYKYERIDGGITGGLRQEAIDRFNA-PGAQQFCF 1094

  Fly  1772 LLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGL 1836
            ||:|..||||:||..|||||..:.||||..|:||..|||||||.|.|.:||.:||.|:||:|..:
  Rat  1095 LLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQV 1159

  Fly  1837 QKFKILTANTVV------------SAENASLQTMGTSQIF-DLFNGGKDKGAESGSSA--VQGTA 1886
            .|.|::..:.||            ..|...:...||.::| |...|...:|....:..  ||.|.
  Rat  1160 AKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDVQSTK 1224

  Fly  1887 SGGMS 1891
            .|.::
  Rat  1225 GGSLA 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	164/548 (30%)
Chd5	XP_017449128.1	CHDNT	144..199	CDD:462357
		PHD1_CHD_II	343..385	CDD:277006
		PHD2_CHD_II	416..458	CDD:277007
		CD1_tandem_CHD3-4_like	463..542	CDD:349314
		CD2_tandem_CHD3-4_like	587..640	CDD:349309	6/52 (12%)
		PLN03142	696..>1214	CDD:215601	170/566 (30%)
		DUF1087	1296..1349	CDD:461922
		CHDII_SANT-like	1390..1530	CDD:461920
		LGT	<1533..1684	CDD:469786
		CHDCT2	1731..1876	CDD:462358