DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hel89B and Chd8

DIOPT Version :10

Sequence 1:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_963999.2 Gene:Chd8 / 67772 MGIID:1915022 Length:2582 Species:Mus musculus


Alignment Length:1414 Identity:330/1414 - (23%)
Similarity:531/1414 - (37%) Gaps:377/1414 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   724 ILAQSNASLKLYLGGSEATPLDVRDANFMRARISSSRALGALSHYLVQPAPGVVY--TPQTESPT 786
            ||:|.|..:     |..||            .:|.|...|..|    |.||.:|.  .|...|.|
Mouse   128 ILSQGNPFM-----GVSAT------------GVSPSNTGGQPS----QSAPKIVILKAPPNSSVT 171

  Fly   787 DCYTKVLLGHLNAH---SAVQRIVCGLI----IAFW-ALEDEPVRPGPPNLQEKLHQCVSEYVYY 843
            ..:    :..:.|.   |..|.:|.|..    :.|. .|...|:|||...:..  :..::..|..
Mouse   172 GTH----VAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSG--NTVLATKVPG 230

  Fly   844 DEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQIEAVATTLSENLRSYPLKPKVL-- 906
            ::.|:.  |::|.::           |:      |.|.|..::..|...:......||||.|.  
Mouse   231 NQAAVQ--RIVQPSR-----------PV------KQLVLQPVKGSAPAGNPGAAGPPLKPAVTLT 276

  Fly   907 ---DMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAIC----ALHCLPDKLNPVVKPLMESIK 964
               ...|.:|.:|.....|:...|...|| ...:|.|.|.    .|..|....|...:|     .
Mouse   277 STPTQGESKRITLVLQQPQSGGPQGHRHV-VLGSLPGKIVLQGNQLAALTQAKNAQGQP-----A 335

  Fly   965 REQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPLETLKQTPVSS 1029
            :...:|||....:..:.::.|.....|.|..          :..|...|   :.|.:::|..:..
Mouse   336 KVVTIQLQVQQPQQKIQIVPQPPSSQPQPQP----------QPPPSAQP---LTLSSVQQAQIMG 387

  Fly  1030 EVINNCVYYGI-LTLALQ-QTVTTTNTRSGAG----------GATTPTATTAPRGPGRPPTGEIL 1082
            ...|......: |.:.|| |..::....||..          .|.:..|:.||...|:  ||   
Mouse   388 PGQNPGQRLSVPLKMVLQPQAGSSQGASSGLSVVKVLSASEVAALSSPASCAPHTAGK--TG--- 447

  Fly  1083 SATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQ-- 1145
                      ::..:..|.:.||.:..|: .|.||.: .|..|||.|.:|.....|...:.|:  
Mouse   448 ----------MEENRRLEHQKKQEKANRI-VAEAIAR-ARARGEQNIPRVLNEDELPSVRPEEEG 500

  Fly  1146 ---FVKEAYDWRLGSLLP---------------DLGVCNELVSSMQLIETAAPHLHVALHPQMF- 1191
               ..|::...||....|               .|.....:|...:...|::.:..|.:.|... 
Mouse   501 EKKRRKKSSGERLKEEKPKKSKTAAASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSP 565

  Fly  1192 ------------------------------------------------------------ALLPS 1196
                                                                        ..|||
Mouse   566 REDEESSIQKRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDGETLPS 630

  Fly  1197 LGFIVCHPLK---AVRHMAARCIAVLAEIDACQTMQ----FVVHDLLPLL----GKIEQLIERQG 1250
            :.|.|.:|.:   |:.........|..|:.:.|..:    ||.:.....|    ..|.|| |:. 
Mouse   631 MQFFVENPSEEDAAIVDKVLSMRVVKKELPSGQYTEAEEFFVKYKNYSYLHCEWATISQL-EKD- 693

  Fly  1251 AIEAIERVVSRLQIKVV-----------PYIVLLVVPLLGAMSDPD--ESVRLL-STHCFAN--- 1298
              :.|.:.:.|.:.|:.           |:             :||  |..|:| .:|....   
Mouse   694 --KRIHQKLKRFKTKMAQMRHFFHEDEEPF-------------NPDYVEVDRILDESHSVDKDNG 743

  Fly  1299 ------LVQ--LMPLDGKTEQLKSDPLQARKTRDREF---------LDYLFNPKSIPNYKVPVPI 1346
                  ||:  .:|.:..|.:||.|   ..:.:.|||         |..:..|::  |....:.:
Mouse   744 EPVIYYLVKWCSLPYEDSTWELKED---VDEGKIREFKRIQSRHPELRRVNRPQA--NAWKKLEL 803

  Fly  1347 SVE------LRCYQQAGINWLWFLNKYNLHG-ILCDDMGLGKTLQTICILAGDHMHRQTANLA-N 1403
            |.|      ||.||..|:|||.| |.||... ||.|:||||||:|:|..|      ::..|:. :
Mouse   804 SHEYKNRNQLREYQLEGVNWLLF-NWYNRQNCILADEMGLGKTIQSIAFL------QEVYNVGIH 861

  Fly  1404 LPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKL-------RSDIGT------KC 1455
            .|.|||.|.:...:|..|...:.:..:::    |:|....|:.:       :...|.      |.
Mouse   862 GPFLVIAPLSTITNWEREFNTWTEMNTIV----YHGSLASRQMIQQYEMYCKDSRGRLIPGAYKF 922

  Fly  1456 NLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVL 1520
            :.::.:::.:..|......|.:...::||.|.:||...|...::|.:...|:::|:|||:||.|.
Mouse   923 DALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVE 987

  Fly  1521 ELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKE 1585
            ||:||..||.|....:|.:|::.|.       |.|:..:.|:     ::|:   :.|.:|||:||
Mouse   988 ELFSLLHFLEPSQFPSESEFLKDFG-------DLKTEEQVQK-----LQAI---LKPMMLRRLKE 1037

  Fly  1586 DVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALR 1650
            ||.|:|.||....:..||:.:|.:.|.....|:........|.::..:::           ..:.
Mouse  1038 DVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLL-----------NTMM 1091

  Fly  1651 YLQNVCNHPKLVLRQSEELT---KVTSQLALSNSSLDDIEHSA-KLPALKQLLLDCGIGVQTESV 1711
            .|:..||||.|:....|::.   :....:...:..|..:..|| ||..:.:||.....|      
Mouse  1092 ELRKCCNHPYLINGAEEKILMEFREACHIIPQDFHLQAMVRSAGKLVLIDKLLPKLKAG------ 1150

  Fly  1712 SQHRALIFCQLKAMLDIVEQDLL-RRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLL 1773
             .|:.|||.|:...|||:|..|: ||:|    |.|:||.|..:.||..::.| |.|..|  |.||
Mouse  1151 -GHKVLIFSQMVRCLDILEDYLIQRRYL----YERIDGRVRGNLRQAAIDRF-SKPDSDRFVFLL 1209

  Fly  1774 TTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKI----- 1833
            .|..||||:|||.|||.|..:.||||..||||..|.|||||.|.|.|||||||||.|.::     
Mouse  1210 CTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKAS 1274

  Fly  1834 --MGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGG--------KDKGAE------------ 1876
              :||.| .:|.:.:........:|.....:|.||...|        .|:|::            
Mouse  1275 LKLGLDK-AVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLR 1338

  Fly  1877 -----------SGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDL 1914
                       .||:..:.:.....:...|..:.|..|.:...:.:.|:
Mouse  1339 RTTTITIESEGKGSTFAKASFVASENRTDISLDDPNFWQKWAKKADLDM 1387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:463447 94/444 (21%)
HepA <1342..1849 CDD:440319 172/541 (32%)
Chd8NP_963999.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..111
SP1-4_N 61..>421 CDD:425404 74/357 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..155 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..377 5/40 (13%)
PTZ00121 <449..624 CDD:173412 24/176 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..585 17/109 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..617 0/18 (0%)
CD1_tandem_CHD5-9_like 640..705 CDD:349315 13/68 (19%)
CD2_tandem_CHD5-9_like 723..781 CDD:349310 16/60 (27%)
PLN03142 812..>1411 CDD:215601 183/626 (29%)
DEAD-like_helicase_N 813..1034 CDD:475120 70/246 (28%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 950..953 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1694..1715
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 1791..2304
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1990..2019
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2045..2120
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2187..2233
BRK 2311..2354 CDD:462196
BRK 2381..2420 CDD:470653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2486..2582
Blue background indicates that the domain is not in the aligned region.

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