DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hel89B and Smarca2

DIOPT Version :10

Sequence 1:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_001392062.1 Gene:Smarca2 / 67155 MGIID:99603 Length:1601 Species:Mus musculus


Alignment Length:1238 Identity:303/1238 - (24%)
Similarity:465/1238 - (37%) Gaps:358/1238 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   882 LDQIEAVATTLSENLRSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALH 946
            |.|:.|.........|..|| |:.|.:..:.:|:|....||...:|.......|....       
Mouse   179 LHQLRAQILAYKMLARGQPL-PETLQLAVQGKRTLPGMQQQQQQQQQQQQQQQQQQQQ------- 235

  Fly   947 CLPDKLNPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEF 1011
              ..:.....:|..::..:.|..|.||.....:.:      :|...|..:       ||.|....
Mouse   236 --QQQQQQPQQPQQQAQAQPQQQQQQQQQPALVSY------NRPSGPGQE-------LLLSGQSA 285

  Fly  1012 TPKLVMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAP------ 1070
            ..||..|..:.:.:|...                              .|..||||..|      
Mouse   286 PQKLSAPAPSGRPSPAPQ------------------------------AAVQPTATAVPGPSVQQ 320

  Fly  1071 RGPGRP------------------PTG----EILS----------------------------AT 1085
            ..||:|                  |.|    |||.                            .|
Mouse   321 PAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRT 385

  Fly  1086 NATAHIELKA--------QQAKEAEA-----------------KQCRIQRLGAACAIEKLCRIFG 1125
            .||  :||||        |..:|..|                 |:.:.|.|..|...|||.:   
Mouse   386 KAT--VELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEK--- 445

  Fly  1126 EQIIEKV------------AVFQHL---------MFGKVEQFVKEAYDWRLGSLLPDLGVCNELV 1169
            :|.||:.            ::.||.         :.||:::..|....|...:.       .|..
Mouse   446 QQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTE-------REQK 503

  Fly  1170 SSMQLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHD 1234
            ...:.||.......:|...:.:.             |.:.....|.:|.|.:    ||.::|.: 
Mouse   504 KETERIEKERMRRLMAEDEEGYR-------------KLIDQKKDRRLAYLLQ----QTDEYVAN- 550

  Fly  1235 LLPLLGKIEQLI-ERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDP-DESVRLLS----- 1292
                   :..|: |.:.|..|.|:...|.:.|..........|.||...:| |||.::..     
Mouse   551 -------LTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKV 608

  Fly  1293 THCFANLVQLMPLDGKTEQL--------------KSDPLQA---------------RKTRDREFL 1328
            ||.....|...|...|..||              :||..::               ::|.::..|
Mouse   609 THTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESESDYEEEDEEEESSRQETEEKILL 673

  Fly  1329 DYLFNPKSIPN------------------------------------YKVPVPIS--VE------ 1349
            |        ||                                    |.|...||  ||      
Mouse   674 D--------PNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALL 730

  Fly  1350 ----LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVIC 1410
                |:.||..|:.|:..|...||:|||.|:||||||:|||.::.....|::    .|.|.|:|.
Mouse   731 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKR----LNGPYLIIV 791

  Fly  1411 PPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGT-KCNLVVASYDTVRKDIDFFSG 1474
            |.:...:|.||.:|:..  ||:: :.|.|.|..|..|...:.: |.|:::.:|:.:.||....:.
Mouse   792 PLSTLSNWTYEFDKWAP--SVVK-ISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAK 853

  Fly  1475 IHFNYCVLDEGHIIKNGKTKSSKAIK-RLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEK 1538
            |.:.|.::||||.:||...|.::.:. ...|..|::|:|||:||.:.|||:|.:||:|....:..
Mouse   854 IRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCS 918

  Fly  1539 QFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCEL 1603
            .|.|.|:.|...:.: :....|:|. :|.:..||:.:.||||||:|::|...||.|:...:.|::
Mouse   919 TFEQWFNAPFAMTGE-RVDLNEEET-ILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDM 981

  Fly  1604 SPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEE 1668
            |.||..||.....|.:     .|.|.|......:. .||| :...:..|:.:||||.:.....|.
Mouse   982 SALQKILYRHMQAKGI-----LLTDGSEKDKKGKG-GAKT-LMNTIMQLRKICNHPYMFQHIEES 1039

  Fly  1669 LTKVTSQLALSNSSLDDIE---HSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVE 1730
            ..:   .|..||..::..|   .|.|...|.::|       .....:.||.|:|||:.:::.|:|
Mouse  1040 FAE---HLGYSNGVINGAELYRASGKFELLDRIL-------PKLRATNHRVLLFCQMTSLMTIME 1094

  Fly  1731 QDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPS-IDVLLLTTMVGGLGLNLTGADTVIFVE 1794
            .....|:.   .||||||:..:..|..::..||...| ..:.||:|..|||||||..||||:..:
Mouse  1095 DYFAFRNF---LYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFD 1156

  Fly  1795 HDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMG 1859
            .||||.:||||.||||||||:..|.|.||.|.||:||||:...|:|:.....|:.|         
Mouse  1157 SDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQA--------- 1212

  Fly  1860 TSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQY-------------EEE 1911
              .:||..:...::.|               .:..|:|:..|...|.:.             |||
Mouse  1213 --GMFDQKSSSHERRA---------------FLQAILEHEEENEEEDEVPDDETLNQMIARREEE 1260

  Fly  1912 YDL 1914
            :||
Mouse  1261 FDL 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:463447 63/348 (18%)
HepA <1342..1849 CDD:440319 182/524 (35%)
Smarca2NP_001392062.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..77
PHA03378 <74..393 CDD:223065 47/268 (18%)
QLQ 173..207 CDD:462622 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..346 28/186 (15%)
HSA 447..519 CDD:214727 12/78 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 562..603 11/40 (28%)
BRK 600..643 CDD:462196 7/42 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 638..683 7/52 (13%)
DEXHc_SMARCA2 712..962 CDD:350821 88/258 (34%)
PLN03142 731..>1213 CDD:215601 178/521 (34%)
DEGH box 862..865 2/2 (100%)
SnAC 1270..1337 CDD:464219
Bromodomain 1344..>1430 CDD:445827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1357..1394
Bromo_SNF2L2 1393..1517 CDD:99947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1517..1601
Blue background indicates that the domain is not in the aligned region.

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