Protein Alignment Hel89B and SMARCA4

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001122321.1
• Gene: SMARCA4 / 6597
• HGNCID: 11100
• Length: 1679
• Species: Homo sapiens
• Alignment Length: 25
• Identity: 8/25 - (32%)
• Similarity: 13/25 - (52%)
• Gaps: 3/25 - (12%)

  Fly   105 VFLTTFMKYQAAK---HVVLPKKNI 126
            :|...|.||:..|   |.:.|:|.:
Human   179 IFRKNFAKYELFKSPPHTLFPEKMV 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319
SMARCA4	NP_001122321.1	DEGH box	881..884
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1254..1299
		SnAC	1322..1389	CDD:464219
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1432..1492
		Bromo_SNF2L2	1490..1596	CDD:99947
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1596..1679
		KIKL. /evidence=ECO:0000269|PubMed:29567837	1628..1631
		Necessary for interaction with SS18L1/CREST. /evidence=ECO:0000250	1..282		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..177
		Med15	42..>222	CDD:312941	8/25 (32%)
		QLQ	171..205	CDD:462622	8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..352		2/6 (33%)
		Smc	<364..>570	CDD:440809
		HSA	460..532	CDD:214727
		RNA-binding region which is sufficient for binding to lncRNA Evf2. /evidence=ECO:0000250|UniProtKB:Q3TKT4	462..728
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..610
		BRK	612..656	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..699
		DEXHc_SMARCA4	731..981	CDD:350820
		PLN03142	750..>1232	CDD:215601
		Sufficient for interaction with DLX1. /evidence=ECO:0000250|UniProtKB:Q3TKT4	837..916