DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and SMARCA1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001269803.1	Gene:	SMARCA1 / 6594	HGNCID:	11097	Length:	1070	Species:	Homo sapiens

Alignment Length:	791	Identity:	237/791 - (29%)
Similarity:	346/791 - (43%)	Gaps:	143/791 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1213 ARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI----------ERVVSRLQIKVV 1267
            |...|.:|..||..|: .|:.|..|.....::......|.||.          |:.||..|:|:.
Human     6 AAVAATVAAADATATI-VVIEDEQPGPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSFQLKLA 69

  Fly  1268 PYIVLLVVPLLGAMSDP--------DESVR----LLSTHCFANLVQ-------LMPLDGK--TEQ 1311
                 ...|......||        |.:.|    |..|..||:.:|       ..||:.|  ..:
Human    70 -----AKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPR 129

  Fly  1312 LKSDPLQA---------RKTRDREFLDYLFNPKSIPNYKVPVPISVE------LRCYQQAGINWL 1361
            :|.|..|:         |:|...|..:.|...:...|..:...:|..      ||.||..|:|||
Human   130 IKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWL 194

  Fly  1362 WFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFL 1426
            ..|.:..::|||.|:||||||||||.:|.....:|....    |.:|:.|.:...:|:.|.::::
Human   195 ISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPG----PHMVLVPKSTLHNWMNEFKRWV 255

  Fly  1427 DQGSVLRPLHYYGFPVGREKLRSD--IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIK 1489
            ..   ||.:.:.|....|.....|  :..:.::.|.||:.|.|:...|...|:.|.|:||.|.||
Human   256 PS---LRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIK 317

  Fly  1490 NGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDA 1554
            |.|:|.|:.::..|:.:||:|:|||:|||:.|||:|.:||:|....:...|...|        |.
Human   318 NEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DT 374

  Fly  1555 KSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHL 1619
            |:...:|:    .:|.||..:.||||||:|.||.|.||||....:...||.:|...|    .|.|
Human   375 KNCLGDQK----LVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWY----TKIL 431

  Fly  1620 KDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLD 1684
            ...:|.|..|....        |..:...|..|:..||||.|...........|.:..:|||.
Human   432 MKDIDVLNSSGKMD--------KMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSG-- 486

  Fly  1685 DIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGS 1749
                       |.::||..:....|..|  |.|||.|:..:|||:|...:.|   ...|.||||.
Human   487 -----------KMVVLDKLLAKLKEQGS--RVLIFSQMTRLLDILEDYCMWR---GYEYCRLDGQ 535

  Fly  1750 VPASQRQD------------IVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMK 1801
            .|..:|:|            .:..||: :.|..:.:|:|..||||:||..||.||..:.||||..
Human   536 TPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQV 600

  Fly  1802 DLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVS------------AENAS 1854
            |||||||||||||||.|.|:||||.|::||:|:...:.|:...:.|:.            |:...
Human   601 DLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEM 665

  Fly  1855 LQTM--GTSQIF-------------DLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWS 1904
            ||.:  |.:.:|             .:...|:.|.||......:...|...:....||.....:.
Human   666 LQMIRHGATHVFASKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFE 730

  Fly  1905 EHQYEEEYDLG 1915
            ...|.|:..||
Human   731 GEDYREKQKLG 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787	7/36 (19%)
		HEAT repeat	1269..1298	CDD:293787	8/40 (20%)
		SNF2_N	1353..1662	CDD:278600	106/310 (34%)
		DEXDc	1370..1514	CDD:238005	49/145 (34%)
		Helicase_C	1689..1813	CDD:278689	52/136 (38%)
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..82		12/61 (20%)
		PLN03142	87..1069	CDD:215601	217/704 (31%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920