DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hel89B and CHD8

DIOPT Version :10

Sequence 1:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_001164100.1 Gene:CHD8 / 57680 HGNCID:20153 Length:2581 Species:Homo sapiens


Alignment Length:1413 Identity:330/1413 - (23%)
Similarity:537/1413 - (38%) Gaps:377/1413 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   724 ILAQSNASLKLYLGGSEATPLDVRDANFMRARISSSRALGALSHYLVQP---APGVVY--TPQTE 783
            ||:|.|..:     |..||            .:|||.|.|       ||   ||.:|.  .|.:.
Human   128 ILSQGNPFM-----GVSAT------------AVSSSSAGG-------QPPQSAPKIVILKAPPSS 168

  Fly   784 SPTDCYTKVLLGHLNAH---SAVQRIVCGLI----IAFW-ALEDEPVRPGPPNLQEKLHQCVSEY 840
            |.|..:    :..:.|.   |..|.:|.|..    :.|. .|...|:|||...:..  :..::..
Human   169 SVTGAH----VAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSG--NTVLAAK 227

  Fly   841 VYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQIEAVATTLSENLRSYPLKPKV 905
            |..::.|:.  |::|.::           |:      |.|.|..::..|...:......||||.|
Human   228 VPGNQAAVQ--RIVQPSR-----------PV------KQLVLQPVKGSAPAGNPGATGPPLKPAV 273

  Fly   906 L-----DMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAIC----ALHCLPDKLNPVVKPLME 961
            .     ...|.:|.:|.....|:...|...|| ...:|.|.|.    .|..|....|...:|   
Human   274 TLTSTPTQGESKRITLVLQQPQSGGPQGHRHV-VLGSLPGKIVLQGNQLAALTQAKNAQGQP--- 334

  Fly   962 SIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLR------SDPEFTP--KLVMP 1018
              .:...:|||....:..:.::.|.....|.|.........||..      ..|..:|  :|.:|
Human   335 --AKVVTIQLQVQQPQQKIQIVPQPPSSQPQPQQPPSTQPVTLSSVQQAQIMGPGQSPGQRLSVP 397

  Fly  1019 LETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEILS 1083
            ::.:.|....|   :.....|:       :|....:.|.....::| |::||...|:  ||    
Human   398 VKVVLQPQAGS---SQGASSGL-------SVVKVLSASEVAALSSP-ASSAPHSGGK--TG---- 445

  Fly  1084 ATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMF------GK 1142
                     ::..:..|.:.||.:..|: .|.||.: .|..|||.|.:|.....|..      |:
Human   446 ---------MEENRRLEHQKKQEKANRI-VAEAIAR-ARARGEQNIPRVLNEDELPSVRPEEEGE 499

  Fly  1143 VEQFVKEAYDWRLGSLLP---------------DLGVCNELVSSMQLIETAAPHLHVALHPQMF- 1191
            .::..|.|.: ||....|               .|.....:|...:...|::.:..|.:.|... 
Human   500 KKRRKKSAGE-RLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSP 563

  Fly  1192 ------------------------------------------------------------ALLPS 1196
                                                                        ..|||
Human   564 REDEESSIQKRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDGETLPS 628

  Fly  1197 LGFIVCHPLKAVRHMAARCIA---VLAEIDACQTMQ----FVVHDLLPLL----GKIEQLIERQG 1250
            :.|.|.:|.:....:..:.::   |..|:.:.|..:    ||.:.....|    ..|.|| |:. 
Human   629 MQFFVENPSEEDAAIVDKVLSMRIVKKELPSGQYTEAEEFFVKYKNYSYLHCEWATISQL-EKD- 691

  Fly  1251 AIEAIERVVSRLQIKVV-----------PYIVLLVVPLLGAMSDPD--ESVRLL-STHCFAN--- 1298
              :.|.:.:.|.:.|:.           |:             :||  |..|:| .:|....   
Human   692 --KRIHQKLKRFKTKMAQMRHFFHEDEEPF-------------NPDYVEVDRILDESHSIDKDNG 741

  Fly  1299 ------LVQ--LMPLDGKTEQLKSDPLQARKTRDREF---------LDYLFNPKSIPNYKVPVPI 1346
                  ||:  .:|.:..|.:||.|   ..:.:.|||         |..:..|::....|:.:..
Human   742 EPVIYYLVKWCSLPYEDSTWELKED---VDEGKIREFKRIQSRHPELKRVNRPQASAWKKLELSH 803

  Fly  1347 SV----ELRCYQQAGINWLWFLNKYNLHG-ILCDDMGLGKTLQTICILAGDHMHRQTANLA-NLP 1405
            ..    :||.||..|:|||.| |.||... ||.|:||||||:|:|..|      ::..|:. :.|
Human   804 EYKNRNQLREYQLEGVNWLLF-NWYNRQNCILADEMGLGKTIQSIAFL------QEVYNVGIHGP 861

  Fly  1406 SLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKL-------RSDIGT------KCNL 1457
            .|||.|.:...:|..|...:.:..:::    |:|....|:.:       :...|.      |.:.
Human   862 FLVIAPLSTITNWEREFNTWTEMNTIV----YHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDA 922

  Fly  1458 VVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLEL 1522
            ::.:::.:..|......|.:...::||.|.:||...|...::|.:...|:::|:|||:||.|.||
Human   923 LITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEEL 987

  Fly  1523 WSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDV 1587
            :||..||.|....:|.:|::.|.       |.|:..:.|:     ::|:   :.|.:|||:||||
Human   988 FSLLHFLEPSQFPSESEFLKDFG-------DLKTEEQVQK-----LQAI---LKPMMLRRLKEDV 1037

  Fly  1588 LKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYL 1652
            .|:|.||....:..||:.:|.:.|.....|:........|.::..:::           ..:..|
Human  1038 EKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLL-----------NTMMEL 1091

  Fly  1653 QNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPAL-----KQLLLDCGIGVQTESVS 1712
            :..||||.|:....|::      |.....:...|.|...|.|:     |.:|:|..:  ......
Human  1092 RKCCNHPYLINGAEEKI------LTEFREACHIIPHDFHLQAMVRSAGKLVLIDKLL--PKLKAG 1148

  Fly  1713 QHRALIFCQLKAMLDIVEQDLL-RRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLT 1774
            .|:.|||.|:...|||:|..|: ||:|    |.|:||.|..:.||..::.| |.|..|  |.||.
Human  1149 GHKVLIFSQMVRCLDILEDYLIQRRYL----YERIDGRVRGNLRQAAIDRF-SKPDSDRFVFLLC 1208

  Fly  1775 TMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKI------ 1833
            |..||||:|||.|||.|..:.||||..||||..|.|||||.|.|.|||||||||.|.::      
Human  1209 TRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASL 1273

  Fly  1834 -MGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGG--------KDKGAE------------- 1876
             :||.| .:|.:.:........:|.....:|.||...|        .|:|::             
Human  1274 KLGLDK-AVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRR 1337

  Fly  1877 ----------SGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDL 1914
                      .||:..:.:.....:...|..:.|..|.:...:.:.|:
Human  1338 TTTITIESEGKGSTFAKASFVASENRTDISLDDPNFWQKWAKKADLDM 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:463447 96/443 (22%)
HepA <1342..1849 CDD:440319 170/540 (31%)
CHD8NP_001164100.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..114
PHA03247 <68..280 CDD:223021 45/200 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..392 7/42 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..582 32/171 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..615 0/18 (0%)
CD1_tandem_CHD5-9_like 638..703 CDD:349315 12/68 (18%)
CD2_tandem_CHD5-9_like 721..779 CDD:349310 16/60 (27%)
PLN03142 810..>1409 CDD:215601 183/627 (29%)
DEXHc_CHD8 811..1032 CDD:350818 70/246 (28%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 948..951 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1692..1712
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124 1789..2302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2189..2229
BRK 2310..2354 CDD:197800
BRK 2379..2419 CDD:197800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2481..2581
Blue background indicates that the domain is not in the aligned region.

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