Protein Alignment Hel89B and chd3

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_009301392.1
• Gene: chd3 / 568230
• ZFINID: ZDB-GENE-121031-4
• Length: 2101
• Species: Danio rerio
• Alignment Length: 692
• Identity: 200/692 - (28%)
• Similarity: 312/692 - (45%)
• Gaps: 140/692 - (20%)

  Fly  1312 LKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVP-ISVE------------LRCYQQAGINWLWF 1363
            :|.||.:.||.|.||..|      ..|:..|..| |..|            |..||..|:|||.|
Zfish   702 MKEDPEKPRKMRRREEND------EAPSTPVNDPTIKYEEQPEFVTETGGTLHLYQLEGLNWLRF 760

  Fly  1364 LNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFL-- 1426
            ........||.|:||||||:|||..|........|..    |.||..|.:...:|..|.|.:.
Zfish   761 SWAQGTDTILADEMGLGKTIQTIVFLYSLFKEGHTKG----PFLVSAPLSTIINWEREFEMWAPD 821

  Fly  1427 ----------DQGSVLRPLHY----YGFPVGRE--KLRSDIGTKCNLVVASYDTVRKDIDFFSGI 1475
                      |..:::|...:    .....|::  |||.:...|.::::.||:.|..|.:....|
Zfish   822 FYVVTYTGDKDSRAIIRENEFTFDDTAVKGGKKAFKLRREAPIKFHVLLTSYELVTIDQNVLKSI 886

  Fly  1476 HFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQF 1540
            .:...|:||.|.:||.::|..:.:...|.:|:|:|:|||:|||:.||:.|.:||.|......:.|
Zfish   887 DWACLVVDEAHRLKNNQSKFFRRLNDYKIDHKLLLTGTPLQNNLEELFHLLNFLTPNRFNNLEGF 951

  Fly  1541 VQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSP 1605
            ::.|:          ..:||.:     ::.||..:.|.:|||:|.||.|::|.|....:..||||
Zfish   952 LEEFA----------DISKEDQ-----IKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSP 1001

  Fly  1606 LQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELT 1670
            :|.:.|:....::. :.|:..|..:..|::           ..:..|:..||||.|....:.|..
Zfish  1002 MQKKYYKFILTRNF-EALNSKGGGNQVSLL-----------NIMMDLKKCCNHPYLFPVAAAEAP 1054

  Fly  1671 KVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLR 1735
            |..|. |.....|  .:.|.||..|:::|       :......||.|:|.|:..|||::| |.|.
Zfish  1055 KTPSG-AYEGVGL--TKASGKLMLLQKML-------RKLKEQGHRVLVFSQMTKMLDLLE-DFLD 1108

  Fly  1736 RHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID-VLLLTTMVGGLGLNLTGADTVIFVEHDWNP 1799
            ..  ...|.|:||.:..:.||:.::.||:..::. ..||:|..||||:||..|||||..:.||||
Zfish  1109 SE--GYKYERIDGGITGALRQEAIDRFNAPGAVQFCFLLSTRAGGLGINLATADTVIIFDSDWNP 1171

  Fly  1800 MKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVV------SAENASLQTM 1858
            ..|:||..|||||||...|.:||.:||.|:||:|..:.|.|::..:.||      .|.:.|.|.:
Zfish  1172 HNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKAGSMSKQEL 1236

  Fly  1859 ------GTSQIF-DLFNGGKDKGAESG-----SSAVQ--------GTASGGM-SMNTII------ 1896
                  ||.::| |....|.:|..:..     ::|::        .|....| :||..:
Zfish  1237 DDILKFGTEELFKDEIEAGDNKDDDMSVIHYDNAAIERLLDRSQDATDDSDMQNMNEYLSSFKVA 1301

  Fly  1897 ---------------------ENL-PELWSE---HQYEEEYD 1913
                                 ||: |:.|.:   |.||::.:
Zfish  1302 QYTVKEDDKIEEIEREIIKQEENVDPDYWEKLLRHHYEQQQE 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	169/544 (31%)
chd3	XP_009301392.1	CHDNT	181..234	CDD:462357
		PHD1_CHD_II	385..427	CDD:277006
		PHD2_CHD_II	470..512	CDD:277007
		CD1_tandem_CHD3-4_like	518..595	CDD:349314
		CD2_tandem_CHD3-4_like	642..696	CDD:349309
		PLN03142	736..>1299	CDD:215601	179/606 (30%)
		DEXHc_CHD3	747..978	CDD:350813	72/249 (29%)
		DUF1087	<1326..1369	CDD:461922	5/18 (28%)
		CHDII_SANT-like	1397..1536	CDD:461920
		CHDCT2	1810..1955	CDD:462358