DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and btaf1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	XP_005169589.1	Gene:	btaf1 / 565357	ZFINID:	ZDB-GENE-021025-1	Length:	1861	Species:	Danio rerio

Alignment Length:	1977	Identity:	894/1977 - (45%)
Similarity:	1214/1977 - (61%)	Gaps:	176/1977 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEA 67
            |||:||||||:||:|..||:|||:|:|:|.||:||||:.||::::.||.|.:|:|||||.|.|||
Zfish     4 SRLERLFILLDTGTTPVTRKAAAQQLGDVVKLHPHELNNLLSKVLTYLRSPNWDTRIAAGQAVEA 68

  Fly    68 ILKQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILHK 132
            |:|.:|.|.|..:  ||.|.||           ||.     |....:::| |||..||:.::|..
Zfish    69 IVKNIPEWNPSPK--PKDEVCA-----------EDL-----SPEDVSTDR-LSFYRFDISRLLKH 114

  Fly   133 GARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDED 197
            ||.|:||.|.||::|:::    .||.|..  .||:|||..|..||||...|.:|::..::..|||
Zfish   115 GASLLGSAGAEFELQDDK----SGETDPK--ERLARQRKQLQKKLGLDMGAAIGMDTEELFNDED 173

  Fly   198 V------ALNRS------GSTYNVNAEKLPVEHLLNIKTAANGSGQAPLSCREMNRAKRKARQNT 250
            :      :.||:      |..::.|  .||...|:      :...:..:|.|:.|:|||.|:.
Zfish   174 LEDACASSTNRTQPGKSLGCHFSRN--HLPAAELI------DSEFRPGMSNRQKNKAKRMAKL-- 228

  Fly   251 SGCSVTAVTPTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLKST---------DRQEIFYS 306
                      ...:|:.:.:.:..||.|..|       |||:|:.|:|         |.:.:..:
Zfish   229 ----------VAKQRSRDVDSNEKSNDSFEG-------EPEEKRRKTTNVVIEQPANDSKVLIDN 276

  Fly   307 LNAAVPDATGTWVDAVSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTR 371
                |||.:..:.:...||||:||..|..|||:..||:||||.|.|||::..|..|.||.|..|.
Zfish   277 ----VPDNSSLFEETQEWPLESFCDELCNDLFNPSWEIRHGAGTGLREVLKCHGAGGGKTVGSTA 337

  Fly   372 EQMDEAHSRWLEDAALRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNI 436
            |||:..|..||||..:|||||..||||||||||:|||||||||||.||..::.||.|.|...|:|
Zfish   338 EQMERQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVALRHMENSGVAMTVDI 402

  Fly   437 LLQLIQHKNEWDVRHGGLLGLKYVFVVREELLPIYLPQSISNILIGLLDAVDDVGAVAAATLIPV 501
            ||:|:. :::|:||||||||:||...||::|:...||:.:..|..||.|..|||.|||||.||||
Zfish   403 LLKLLT-EDQWEVRHGGLLGIKYALAVRQDLIAELLPRVLPAITEGLRDLDDDVRAVAAAALIPV 466

  Fly   502 SSWLPKLLNPAQVSSIVKMLWDLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPR 566
            ...|.: |.||:|..||..||:.||:.|:||::.||.|.||:::|..|...:....:.:.:||||
Zfish   467 VDGLVQ-LQPAKVPFIVDTLWNALLELDDLTASTNSIMTLLSSLLTYPQVRQCSTQQSLTVLVPR 530

  Fly   567 LWPFLSHSTSSVRRSTLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWELLQQA 631
            :||||.|:.:||||:.|.||.||.|                :||:       ..:.|...::|..
Zfish   531 VWPFLRHTIASVRRAALDTLFTLLS----------------KADQ-------SCAVWLNPIMQDM 572

  Fly   632 LRHIYQRILVEPQADIQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFDAGVLI 696
            ||||:|..::|...:|..|.::||..|::.|....::.|:||::.:|:||.||.|.:..|..:|:
Zfish   573 LRHIFQSCILESNQEILELIQKVWRELLRQAPQQYVVAASCPWMGAWLCLMMQAPHIPIDPNMLL 637

  Fly   697 RAGGDVSTPGSTSRKRTPRIGDELGGNILAQSNASLKLYLGGSEATPLD--VRDANFMRARISSS 759
            ..         .:|.:....|....|::..:.  :::.|:||:|....:  .||....|||:.::
Zfish   638 EV---------KARFKEKAAGKARQGSVPVKE--TVQEYIGGAETVTEEPATRDYVVTRARLMAA 691

  Fly   760 RALGALSHYLVQPAPGVVYTPQTE-SPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDEPVR 823
            :.||||...:..|.   :.:...| .|.:...::||.|||:.||:|||...::|..||...:...
Zfish   692 KLLGALCSCICDPR---LNSSSLELRPAESLAQLLLFHLNSKSALQRIAVSMVICEWAGLQKECE 753

  Fly   824 PGPPNLQEKLHQCVSEYVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQI-EA 887
            .....:|.:|...:||.:||||:||..||:..|.:..||.|....|.:.:..|:.:.|:||. |.
Zfish   754 LLSSVVQPRLLVILSEQLYYDEIAIPFTRMQNECKQLIALLADAHIDVRERINSTVFTIDQANEL 818

  Fly   888 VATTLSENLRSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKL 952
            |.|..||:..:..||.:....|:.:|...|::..:|::|.....:......|.|:..|..|||||
Zfish   819 VTTIFSESTSTLNLKSRQFQPLDSKRIQAQSTVCETSAEWQQLQLRVHTFTACAVVGLGMLPDKL 883

  Fly   953 NPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVM 1017
            ||||:||||:.:||:...:|..:|..:.||:.....|:|.||:||:.|||:.:..||..||....
Zfish   884 NPVVRPLMEAARREENSLVQGCAASNIAHLLQLCAARSPCPNAKIVKNLCSSVCVDPMLTPSAAC 948

  Fly  1018 PL--------ETLKQTPVSSEVINNCV--YYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRG 1072
            |:        |:.|.:....:.:::.|  ..||:||...|...              .|.|:.||
Zfish   949 PVPPASTPIQESSKASVAEKDAMHHMVNKTKGIITLYRHQKAA--------------FAITSKRG 999

  Fly  1073 PGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQH 1137
            | .|.|.:  |.||....:........:...|.|.|||.||...:..:.|.|.:::.:.:.....
Zfish  1000 P-TPKTPK--SNTNNDLPVGGSISTETDESKKPCLIQRRGAEFCLMTVARHFSKELTKTLPYLWE 1061

  Fly  1138 LMFGKVEQFVKEAYDWRLGSLLPD-LGVCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIV 1201
            .|.|.:...: :|.::....||.. ..|..:||:|:|::|..|..:...|.|.:...||.|...:
Zfish  1062 SMTGPLRNAL-DAQEFDSSQLLKQGDSVAQDLVNSLQVLEVTAGAMSQELIPLLMEQLPLLCTCL 1125

  Fly  1202 CHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKV 1266
            .||..|||||||||:.||::|...:||...:..:||.||.|:...:::|||||:..|:.:|.:.:
Zfish  1126 QHPYTAVRHMAARCVGVLSKIATMETMNVFLEQVLPWLGAIDDNTKQEGAIEALACVMEQLDVDI 1190

  Fly  1267 VPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDG--KTEQLKSDPLQARKTRDREFLD 1329
            ||||||||||:||.||||.:|||.::|.|||.|::|:||:.  ......|:.|..:|.|:|.||:
Zfish  1191 VPYIVLLVVPVLGRMSDPCDSVRFMATQCFATLIRLLPLEAGIPDPPSMSEDLIRQKARERHFLE 1255

  Fly  1330 YLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHM 1394
            .|.:.:.:.|||:||||..|||.|||.|:|||.|||||.||||||||||||||||:||||||||.
Zfish  1256 QLLDGRKLENYKIPVPIKAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHF 1320

  Fly  1395 HR-------QTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIG 1452
            .|       :..:...|||:|:||||||||||.||.||..: ..|.||||.|.|..|.:|:..:
Zfish  1321 LRAQEYTRTKAPDSCPLPSIVVCPPTLTGHWVDEVGKFCSK-EFLNPLHYTGPPTERARLQHQV- 1383

  Fly  1453 TKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQN 1517
            .|.||:|||||.||.|::||..|.||||:|||||:|||||||.|||||:|.||:|||||||||||
Zfish  1384 KKHNLIVASYDVVRNDVEFFRDIKFNYCILDEGHVIKNGKTKLSKAIKQLTANYRLILSGTPIQN 1448

  Fly  1518 NVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRR 1582
            ||||||||||||||||||||:||..|:.:|||:|||||||::|||||||||||||||||||||||
Zfish  1449 NVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDAKSSSREQEAGVLAMEALHRQVLPFLLRR 1513

  Fly  1583 VKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTE--NLSAKTHI 1645
            :|:|||:||||||.||..|.|||||::|||||:....|..:|.:..::|.....|  .|.|..|:
Zfish  1514 MKDDVLQDLPPKIIQDYYCNLSPLQVQLYEDFAKSRAKVNVDDVISTASTQEDEEKPKLKATGHV 1578

  Fly  1646 FQALRYLQNVCNHPKLVLR-QSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQ-- 1707
            ||||:||:.:||||.|||. |..|...:|.||:..:|||.||:|:.||.||||||||||:|..
Zfish  1579 FQALQYLRKLCNHPALVLTPQHPEYKHITEQLSTQHSSLRDIQHAPKLSALKQLLLDCGLGSAGA 1643

  Fly  1708 ----TES-VSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPS 1767
                ||: |:|||.|||||||:||||||||||:..||.||||||||||.|..|..||:.||:|||
Zfish  1644 SDSGTEAVVAQHRVLIFCQLKSMLDIVEQDLLKPQLPGVTYLRLDGSVQAGLRHSIVSRFNNDPS 1708

  Fly  1768 IDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEK 1832
            ||||||||.||||||||||||||:|||||||||:||||||||||||||:||||||||||.:||||
Zfish  1709 IDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEK 1773

  Fly  1833 IMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAE--SGSSAVQGTASGGMSMNTI 1895
            ||||||||:..||||:|.||||||:|||.|:.:||...||..||  .|||    ::||..||.::
Zfish  1774 IMGLQKFKMTIANTVISQENASLQSMGTEQLLNLFTLDKDDKAEKCDGSS----SSSGKSSMKSV 1834

  Fly  1896 IENLPELWSEHQYEEEYDLGNFVQALK 1922
            ::.|.:||.:.|||.|||||.|:.:||
Zfish  1835 LDGLGDLWDQQQYENEYDLGTFMHSLK 1861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787	16/24 (67%)
		HEAT repeat	42..70	CDD:293787	16/27 (59%)
		HEAT repeat	395..420	CDD:293787	22/24 (92%)
		HEAT repeat	433..465	CDD:293787	17/31 (55%)
		HEAT repeat	475..504	CDD:293787	16/28 (57%)
		HEAT repeat	516..540	CDD:293787	11/23 (48%)
		HEAT repeat	560..589	CDD:293787	16/28 (57%)
		DUF3535	654..1138	CDD:288874	143/497 (29%)
		HEAT repeat	1234..1261	CDD:293787	11/26 (42%)
		HEAT repeat	1269..1298	CDD:293787	20/28 (71%)
		SNF2_N	1353..1662	CDD:278600	209/317 (66%)
		DEXDc	1370..1514	CDD:238005	95/150 (63%)
		Helicase_C	1689..1813	CDD:278689	98/130 (75%)
btaf1	XP_005169589.1	DUF3535	595..1062	CDD:288874	143/497 (29%)
		HEAT repeat	1063..1100	CDD:293787	10/37 (27%)
		HEAT repeat	1110..1146	CDD:293787	18/35 (51%)
		HEAT repeat	1158..1181	CDD:293787	10/22 (45%)
		HEAT repeat	1194..1223	CDD:293787	20/28 (71%)
		SNF2_N	1279..1595	CDD:278600	209/317 (66%)
		DEXDc	1296..1445	CDD:238005	95/150 (63%)
		HELICc	1625..1762	CDD:238034	105/136 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576614
Domainoid	1	1.000	432	1.000	Domainoid score	I562
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31978
Inparanoid	1	1.050	1510	1.000	Inparanoid score	I100
OMA	1	1.010	-	-		QHG55547
OrthoDB	1	1.010	-	-		D29546at33208
OrthoFinder	1	1.000	-	-		FOG0004898
OrthoInspector	1	1.000	-	-		oto41545
orthoMCL	1	0.900	-	-		OOG6_101665
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R735
SonicParanoid	1	1.000	-	-		X3453
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840