Protein Alignment Hel89B and rad54b

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_688979.4
• Gene: rad54b / 560482
• ZFINID: ZDB-GENE-060810-50
• Length: 917
• Species: Danio rerio
• Alignment Length: 766
• Identity: 216/766 - (28%)
• Similarity: 327/766 - (42%)
• Gaps: 181/766 - (23%)

  Fly  1241 KIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPL 1305
            ::|.|.|.|      ..:|...||:|           :|.:||.|.:    ...||.:....:|.
Zfish   182 ELESLCEGQ------TLMVGGKQIEV-----------MGVISDQDYA----KGRCFQDAAVEIPA 225

  Fly  1306 DGKT----------------EQLKS-----------------DP------LQARKTRDREFLDYL 1331
            :..|                ..||.                 ||      :..|.|.|.:   :.
Zfish   226 ESPTVSKTPAYRPVSKSFTKPALKGGALTDSELDKPICKPRYDPNAPGALVMPRPTADHQ---WQ 287

  Fly  1332 FNPKSIPNYKVPVP--ISVELRCYQQAGINWLW-FLNKYNLHG----ILCDDMGLGKTLQTICIL 1389
            :|....|...|.:.  ::..||.:|:.|:.:|: .|....|.|    ||.|:||||||||.:|:|
Zfish   288 YNKSGAPLVDVVIDPHLTNHLRPHQKEGVVFLYECLMGMRLAGRCGAILADEMGLGKTLQCVCVL 352

  Fly  1390 -----AGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLR- 1448
                 .|.:..|.....|    ||:||.:|..:|..|..|:|                |||::.
Zfish   353 WTLLRQGPYGGRPVMKRA----LVVCPGSLVKNWAAEFNKWL----------------GRERISV 397

  Fly  1449 ---------SDIGTK--CNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRL 1502
                     .|..:.  |:::|.||:.:.:.:|....:.|...:.||||.:||...|::.|:..|
Zfish   398 YTVDQDHRVEDFVSSPLCSVLVISYEMLLRSVDRLKELDFGVLICDEGHRLKNSNIKTAGALTAL 462

  Fly  1503 KANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLA 1567
            ....||||:|||:||::.|.:|:.:|:.||.|||...:.:.:..|||.||....:.:|:..|...
Zfish   463 SCTRRLILTGTPVQNDLQEFYSIIEFVNPGILGTSAAYRKIYEEPILRSRQPSCTEEERCIGEER 527

  Fly  1568 MEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYED-FSNKHLKDCLDKLGDSSS 1631
            ...|.|....|.|||.:|.:.:.|..:|...:.|:.:.||:|||.. .|.:.::.||      |.
Zfish   528 AAELFRLTGVFTLRRTQEIINQYLSERIEWTVFCKPTELQIRLYRVLLSTRPIRACL------SG 586

  Fly  1632 ASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEE-------------LTKVTSQLALSNSSL 1683
            :...|.:    .|:. .:..|:.:||||.|:....:|             ..:..|..|.|.:.
Zfish   587 SHTYTHS----PHLV-CINALKKLCNHPALLYNTLQEKADEMYEGEVKELFPEEYSTGAFSTAD- 645

  Fly  1684 DDIEHSAKLPALKQLLLDCGIGVQTESVSQH-----RALIFCQLKAMLDIVEQDLLRRHLPSVTY 1743
                 |.||..|..||          |..||     |.::.......||:: ||:..:  ....:
Zfish   646 -----SGKLLVLTDLL----------SAIQHVNRTDRVVLVSNHTQTLDLL-QDVCDQ--IGYKW 692

  Fly  1744 LRLDGSVPASQRQDIVNNFNSDPSID-VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMD 1807
            .||||..|..|||.||::|||..|.. :|||::..||:||||.||..::..:.||||..|:|||.
Zfish   693 CRLDGQTPVGQRQKIVDSFNSPHSSSFLLLLSSKAGGVGLNLIGASHLVLYDIDWNPANDIQAMA 757

  Fly  1808 RAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVV----SAENASLQTMGTSQIF---- 1864
            |..|.||||.|::||.:|..|:||||...|..|...:.|||    .||:.|........:|
Zfish   758 RVWRDGQKKTVHIYRFLTTGSIEEKIYQRQVSKQGLSGTVVDLTKKAEHISFSAEELRDLFRFDP 822

  Fly  1865 -------DLFN-----GGKDKGAESGSSAVQGTAS--GGMSMNTIIENLPE 1901
                   ||.|     .|...|:...||...|.:.  |..:.|.|  ::|:
Zfish   823 NTTCLTHDLLNCKCSGDGNTPGSVKESSEDTGRSCQLGRQADNAI--SVPQ 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	175/554 (32%)
rad54b	XP_688979.4	HepA	<308..799	CDD:440319	173/540 (32%)
		DEAD-like_helicase_N	308..542	CDD:475120	80/253 (32%)