DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and hells

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001032178.1	Gene:	hells / 553328	ZFINID:	ZDB-GENE-030131-9923	Length:	853	Species:	Danio rerio

Alignment Length:	662	Identity:	204/662 - (30%)
Similarity:	298/662 - (45%)	Gaps:	143/662 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1325 REFLDYLFNPKSIPNYKVPVPISVE-------LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKT 1382
            ||....:.:|:...|.: |||....       :|.||..||.||..|.:..::|||.|:||||||
Zfish   202 RENSKQMLDPERTVNGQ-PVPAQQPQLFTGGVMRWYQVEGIEWLRMLWENGINGILADEMGLGKT 265

  Fly  1383 LQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGR--- 1444
            :|.|.     |:..........|.||:.|.:...:|:.|.::|..:.|||.   |:|....|
Zfish   266 IQCIA-----HIAMMVEKKVLGPFLVVAPLSTLPNWISEFKRFTPEVSVLL---YHGPQKERLDL 322

  Fly  1445 -EKLRSDIGT--KCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANH 1506
             :|:|...|:  .|.:||.|::...:|..|....|:||.::||||.|||...:..:.:|.|..::
Zfish   323 VKKIRQHQGSLRMCPVVVTSFEIAMRDRKFLQRFHWNYLIVDEGHRIKNLNCRLVQELKMLPTDN 387

  Fly  1507 RLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEAL 1571
            :|:|:|||:|||:.|||||.:||:|......|.|...|....::|......|.|:|..:|.|  |
Zfish   388 KLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDISTITSDAENIVANEREQNILHM--L 450

  Fly  1572 HRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVT 1636
            |..:.||||||:|.||..::|||....:...|:..|...|....||.:...|.:..|.|:.:.:|
Zfish   451 HLILTPFLLRRLKSDVTLEVPPKKEIVVYAPLTNKQEAFYMAIVNKTIAKLLGQEKDESAPAPLT 515

  Fly  1637 ENLSAKTHIFQALRY---------------------------------------------LQNV- 1655
            .:...|....:.:.|                                             |||:
Zfish   516 PSGRPKRRSRKVVNYTEPNTDSMKDLEKYLEKVQQELDSQASSTPVVNVFMPVDAQVNLKLQNIL 580

  Fly  1656 ------CNHPKLVLRQSEELT---KVTSQLALSNSSLDDIEHSAK-------LPALKQLLLDCGI 1704
                  |||..|:....:..|   |:..||         :|.|.|       ||.||:
Zfish   581 MLLKRCCNHAYLIEYPLDPTTGDFKIDEQL---------VEASGKFLILDRMLPELKK------- 629

  Fly  1705 GVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID 1769
                   ..|:.|||.|:.::|||: .|..  :|....|.|||||:..:.|.:.:..|:|||.:.
Zfish   630 -------RGHKVLIFSQMTSILDIL-MDYC--YLRGYEYSRLDGSMSYADRDENMKKFSSDPEVF 684

  Fly  1770 VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIM 1834
            :.||:|..||||:|||.|||||..:.||||..||||.||.|||||.|.|.|:||||.|:::|||:
Zfish   685 LFLLSTRAGGLGINLTSADTVIIFDSDWNPQADLQAQDRCHRIGQTKPVVVHRLITANTIDEKIL 749

  Fly  1835 GLQKFKILTANTVVSAENASLQTMGTSQIF--DLFNGGKDKGAESGSSAVQGTASGGMSMNTIIE 1897
                            |.||.:......:.  :.|.|.|.:..:|.|.             ..::
Zfish   750 ----------------ERASAKRKLEKMVIHKNKFKGSKAELKQSKSC-------------LDVD 785

  Fly  1898 NLPELWSEHQYE 1909
            .|.||.....|:
Zfish   786 ELVELLKSRDYD 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	110/366 (30%)
		DEXDc	1370..1514	CDD:238005	50/149 (34%)
		Helicase_C	1689..1813	CDD:278689	54/130 (42%)
hells	NP_001032178.1	nuclear localization signal	140..145
		SNF2_N	236..510	CDD:278600	100/283 (35%)
		conserved domain I	241..265		12/23 (52%)
		DEXDc	253..395	CDD:238005	50/149 (34%)
		conserved domain Ia	285..294		3/8 (38%)
		conserved domain II	353..371		8/17 (47%)
		leucine zipper motif	389..410		13/20 (65%)
		conserved domain III	390..397		4/6 (67%)
		conserved domain IV	456..466		7/9 (78%)
		Shugoshin_C	518..>534	CDD:284886	2/15 (13%)
		conserved domain IVa	580..592		3/11 (27%)
		SrmB	<605..832	CDD:223587	84/248 (34%)
		Helicase_C	614..728	CDD:278689	54/130 (42%)
		conserved domain IVb	631..642		5/10 (50%)
		conserved domain V	688..701		8/12 (67%)
		conserved domain VI	719..729		7/9 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920