Protein Alignment Hel89B and SMARCAL1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Alignment Length: 1106
• Identity: 255/1106 - (23%)
• Similarity: 422/1106 - (38%)
• Gaps: 290/1106 - (26%)

  Fly   906 LDMLEERRRSLQASYQQTTSEQSAYHVSA--QAALAGAICALHCLPDKLNPVVKPLMESIKREQC 968
            |.:.||:|:.::.:.|:..:.::...::.  |...:|...|.:....|..|     .::..||.|
Human     3 LPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGP-----SQNFPRESC 62

  Fly   969 --------LQLQQLSAEFLVHLMDQVCDRNP-------------------------SPNSKI-LN 999
                    .:.|.||:       ....|:.|                         ||.|:: |.
Human    63 KPVSHGVIFKQQNLSS-------SSNADQRPHDSHSFQAKGIWKKPEEMPTACPGHSPRSQMALT 120

  Fly  1000 NLC-TLLRSDPEFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATT 1063
            .:. .|.:|.||...:.::..|..:....:|..|....:.......|.:..::..|.:.:.|...
Human   121 GISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPP 185

  Fly  1064 PTATTAPRGPGRPPTGEIL-----SATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRI 1123
            ..|....:.....|:|:.:     |:.:.|...|.:.|| |...:.|..:......|...
Human   186 RDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQ-KSGSSVQKGVNSQKGKCVRN----- 244

  Fly  1124 FGE--QII-----EKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPH 1181
             |:  |::     |.:|||:.|        ..:.||       ||....|..::....:..||..
Human   245 -GDRFQVLIGYNAELIAVFKTL--------PSKNYD-------PDTKTWNFSMNDYSALMKAAQS 293

  Fly  1182 L-HVALHPQMFAL------------------LPSLGFIVCHPLKAVRHMAARCIAVL-----AEI 1222
            | .|.|.|..:|.                  .|||.|:           ..||:.:.     |:|
Human   294 LPTVNLQPLEWAYGSSESPSTSSEGQAGLPSAPSLSFV-----------KGRCMLISRAYFEADI 347

  Fly  1223 DACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDES 1287
            ...|       ||:.|..:::.               .|..:|...:..||           :|.
Human   348 SYSQ-------DLIALFKQMDS---------------RRYDVKTRKWSFLL-----------EEH 379

  Fly  1288 VRLLS-THCFANLVQLMPLD-----GKTEQLKSDPLQARKTRDREFLDYL-FNPKSIPNYKVPVP 1345
            .:|:: ..|... |||.||.     ....|||...|..  |.|....|.. .:||.:.|
Human   380 SKLIAKVRCLPQ-VQLDPLPTTLTLAFASQLKKTSLSL--TPDVPEADLSEVDPKLVSN------ 435

  Fly  1346 ISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVIC 1410
                |..:|:||:|   |........:|.||||||||:|.|||.|   .:|:     ..|.||:.
Human   436 ----LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAA---FYRK-----EWPLLVVV 485

  Fly  1411 PPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTVRKDIDFFSGI 1475
            |.::...|   .:.||.....|.|........|:::|.:.:     :.:.|:|.:.| ::.....
Human   486 PSSVRFTW---EQAFLRWLPSLSPDCINVVVTGKDRLTAGL-----INIVSFDLLSK-LEKQLKT 541

  Fly  1476 HFNYCVLDEGHIIKNGKT-KSSKAIKRLKANHRLI-LSGTPIQNNVLELWSLFDFLMPGFLGTEK 1538
            .|...::||.|.:||.:| :...|:..||...|:| |||||..:...||::....:.|.|.....
Human   542 PFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFH 606

  Fly  1539 QFVQRFSRPILSSRDAK---------SSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPK 1594
            .|..|:.       |||         .|:...|..:|..||:       :|||:|.|||..||.|
Human   607 AFGLRYC-------DAKRMPWGWDYSGSSNLGELKLLLEEAV-------MLRRLKSDVLSQLPAK 657

  Fly  1595 ITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHP 1659
              |..:..::|.::       |...:..|    |:::..|.|::
Human   658 --QRKIVVIAPGRI-------NARTRAAL----DAAAKEMTTKD--------------------- 688

  Fly  1660 KLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKA 1724
            |...:|.:.|....::.|           .||:|::.:.:||.     .|| .:.:.|:|...|.
Human   689 KTKQQQKDALILFFNRTA-----------EAKIPSVIEYILDL-----LES-GREKFLVFAHHKV 736

  Fly  1725 MLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADT 1789
            :||.:.|:|.|:|   |.::|:|||..:::|:|:...|.......|.:|:.....:||..:.||.
Human   737 VLDAITQELERKH---VQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADL 798

  Fly  1790 VIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGL--QKFKILTANTVVSAEN 1852
            |:|.|..|||...:||.||.|||||...|.::.|:.:.:.::.:..|  :|.|:| |...:|..|
Human   799 VVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVL-AEAGLSETN 862

  Fly  1853 ASLQTMGT---------SQIFDLFNGGKDKGA------ESGSSAVQGTASG--GMSMNTIIENLP 1900
            .|..|..|         .:|:|||....:|..      |:..|...|:|||  |.|...:.:.|.
Human   863 FSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAESFDPGSASGTSGSSSQNMGDTLD 927

  Fly  1901 E 1901
            |
Human   928 E 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	49/280 (18%)
		HepA	<1342..1849	CDD:440319	139/519 (27%)
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		5/16 (31%)
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		37/223 (17%)
		HARP	248..302	CDD:462166	16/68 (24%)
		HARP	343..397	CDD:462166	16/87 (18%)
		HepA	<423..856	CDD:440319	143/531 (27%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	67/242 (28%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		9/25 (36%)