DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and smarca5

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001007993.1	Gene:	smarca5 / 493355	XenbaseID:	XB-GENE-494817	Length:	1049	Species:	Xenopus tropicalis

Alignment Length:	674	Identity:	208/674 - (30%)
Similarity:	306/674 - (45%)	Gaps:	100/674 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1279 GAMSDP--------DESVR----LLSTHCFANLVQ-------LMPL-----------DGKTEQLK 1313
            |...||        |.|.|    |..|..||:.:|       ..||           |.|.:.|.
Frog    69 GNEMDPAYEEKRKTDRSNRFEYLLKQTEVFAHFIQPAAQKTPTSPLKMKPGRPRLKKDEKQDLLS 133

  Fly  1314 SDPLQARKTRDREFLDYLFNPKSIPNYKV---PVPISVE---LRCYQQAGINWLWFLNKYNLHGI 1372
            ....:.|:|...|..:.|.......|...   ..|..|:   ||.||..|:|||..|.:..::||
Frog   134 MGDYRHRRTEQEEDEELLTESSKTTNVCTRFEDSPSYVKGGTLRDYQVRGLNWLISLYENGINGI 198

  Fly  1373 LCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHY 1437
            |.|:||||||||||.:|.....:|....    |.:|:.|.:...:|:.|.::::..   |..:..
Frog   199 LADEMGLGKTLQTISLLGYMKHYRSIPG----PHMVLVPKSTLHNWMAEFKRWVPS---LCAICL 256

  Fly  1438 YGFPVGREKLRSDI--GTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIK 1500
            .|....|.....|:  ..:.::.|.||:.:.|:...|...::.|.|:||.|.|||.|:|.|:.::
Frog   257 IGDKDHRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVR 321

  Fly  1501 RLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGV 1565
            ..|..:||:|:|||:|||:.|||:|.:||:|....:.:.|...|        |..:...:|:
Frog   322 EFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF--------DTNNCLGDQK--- 375

  Fly  1566 LAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSS 1630
             .:|.||..:.||||||:|.||.|.||||....:...||.:|...|    .|.|...:|.|..|.
Frog   376 -LVERLHMVLKPFLLRRIKADVEKSLPPKKEIKIYVGLSKMQREWY----TKILMKDIDILNSSG 435

  Fly  1631 SASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPAL 1695
            ...        |..:...|..|:..||||.| ...:|.....|:.:.|..:|...:.....||.|
Frog   436 KTD--------KMRLLNILMQLRKCCNHPYL-FDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPRL 491

  Fly  1696 KQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVN 1760
            |:              ...|.|||.|:..:|||:|...:.|   :..|.||||..|..:|||.:.
Frog   492 KE--------------QGSRVLIFSQMTRVLDILEDYCMWR---NYEYCRLDGQTPHEERQDSII 539

  Fly  1761 NFNSDPSID-VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLI 1824
            .:|:..|.. :.:|:|..||||:||..||.||..:.||||..|||||||||||||.|.|.|:|.|
Frog   540 AYNAPGSSKFIFMLSTRAGGLGINLATADVVIIYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRYI 604

  Fly  1825 TRNSLEEKIMGLQKFKILTANTVVS---AENASLQTMGTSQIFDLFNGG-----KDKGAESGSSA 1881
            |.|::||:|:...:.|:...:.|:.   ..:.:|..:|..::..:...|     ..|.:|.....
Frog   605 TDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKLGKDEMLQMIRHGATHVFASKDSEITEED 669

  Fly  1882 VQGTASGG----MSMNTIIENLPE 1901
            :......|    ..||..:.|:.|
Frog   670 INAILERGEKKTAEMNEKLSNMGE 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787	9/30 (30%)
		SNF2_N	1353..1662	CDD:278600	102/310 (33%)
		DEXDc	1370..1514	CDD:238005	46/145 (32%)
		Helicase_C	1689..1813	CDD:278689	51/124 (41%)
smarca5	NP_001007993.1	PLN03142	7..1004	CDD:215601	208/674 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010