Protein Alignment Hel89B and dom

DIOPT Version :9

• Sequence 1: NP_001287351.1
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Alignment Length: 1947
• Identity: 377/1947 - (19%)
• Similarity: 582/1947 - (29%)
• Gaps: 857/1947 - (44%)

  Fly   698 AGGDVSTPGST-------SRKRTPRIGDELGGNILAQSNASLKLYLGGSEATPLDVRDANFMRAR 755
            |..:||...||       .:.:..|:.|.       :...|....:|.:|::.:   .::.:.|.
  Fly   111 AHSNVSVSSSTIEASVLPPQAKRQRLDDN-------EDRTSAASIVGPAESSNI---VSSLLPAS 165

  Fly   756 ISSSRALGALSHYLVQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE 820
            ::||..:|.||...:|.                     |..|......|::             :
  Fly   166 VASSSEVGGLSSTALQD---------------------LNALKKRILQQKL-------------Q 196

  Fly   821 PVRPGPPNLQEKLHQCVSEYVYYDEVAISLTRLLQEA---QDFIATLKQNKIP-INDFNNAKIL- 880
            .:|    ||:|:..:.||||.|           ||..   .|:.|..|:...| ...::||..:
  Fly   197 ILR----NLKERHLENVSEYFY-----------LQNGGSMMDYPAWRKKTPTPQFISYSNANRID 246

  Fly   881 ----------------------TLDQIEAVATTLSENL-----RSYPLK---------------- 902
                                  |..|.::|.::|...:     :..||.
  Fly   247 QLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISNSTVKTNTQSQV 311

  Fly   903 PKVLDMLEERRRSLQASYQQTT-----SEQSAYHVSAQAALA-GAICALHCLPDKLNPVVKPLME 961
            |..:....|...:...|...||     :..:|...||.:|.| |.:.|:..  :...|.|.....
  Fly   312 PSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEA--EIKIPAVGATPV 374

  Fly   962 SIKREQCLQLQQLSAEFLV--------HLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMP 1018
            :|..:....:.||:.:..:        |.|  |..:.|:|.:.:.|....|:   |..||  ::|
  Fly   375 AISTKLPAAVVQLTQQGHIPGRPLGGRHGM--VFGQIPAPPAAVGNPSVPLV---PGGTP--LLP 432

  Fly  1019 LETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGA------GGATTPTATTAPRG----- 1072
            ..|                 ...:.||::.....|..||:      ||:.|||......|
  Fly   433 CNT-----------------SAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPAALG 480

  Fly  1073 ------PGRPPTGEILS---------ATNATAHIELKAQQA------------------------ 1098
                  ||.|.:|.:||         ..:|......||:|.
  Fly   481 GSGGLTPGTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKL 545

  Fly  1099 ------------------------------KEAEAKQC-------------RIQRLGAA--CAIE 1118
                                          |:..||:|             ..||...|  ..::
  Fly   546 QEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLK 610

  Fly  1119 KLCRIFGEQI------IEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDL-GVCNELVSSMQLIE 1176
            ::......::      :||:..::|..  |:|:..|:|.|..|..::... ....:||..|....
  Fly   611 RVASFIAREVKSFWSNVEKLVEYKHQT--KIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSV 673

  Fly  1177 TAAPHLHVA--LHPQMFA---LLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFV----- 1231
            ...|.|:.:  ..|:..:   ..|..|          .......|| .||.||....:.|
  Fly   674 ADTPSLNSSRLTSPKRESDDDFRPESG----------SEDDEETIA-KAEEDAADVKEEVTALAK 727

  Fly  1232 ---------VHDLLP-------LLGKIEQL---------------IERQGAIEAIERVVSRLQ-- 1263
                     ::||.|       .|.|.||.               .|.:.|.:..|..:|:.:
  Fly   728 ESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEA 792

  Fly  1264 ------IKVVPYIV----LLVVPLLG---------------AMSDP-----DESVRLLSTH---- 1294
                  .|.:..:.    |.|..||.               |..||     |:|..:.||.
  Fly   793 EQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESED 857

  Fly  1295 ----------CFANLVQLMPLDGKTEQLKSDPLQARKT--------------------RDREFLD 1329
                      .......:...|.:.:.|||....|..|                    .|...|.
  Fly   858 AATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALA 922

  Fly  1330 YLFNPK----SIPNYKVPVPISVE--LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICI 1388
            ....||    |..|...|||..::  ||.||..|::||..:|:..|:|||.|:||||||:|||.:
  Fly   923 ESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIAL 987

  Fly  1389 LAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGT 1453
            ||  |:.....|..  |.|::.|.::..:|..|.:|:.....:|.   |||....| ||:....|
  Fly   988 LA--HLACAKGNWG--PHLIVVPSSVMLNWEMEFKKWCPGFKILT---YYGSQKER-KLKRVGWT 1044

  Fly  1454 KCN---LVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPI 1515
            |.|   :.:.||..|.:|...|....:.|.:|||...|||.|::..:.:.......||:|:|||:
  Fly  1045 KPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPL 1109

  Fly  1516 QNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLL 1580
            ||:::|||||..||||....:.::|.:.||.|:....:......|     ..:..||:.:.||||
  Fly  1110 QNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNE-----TLITRLHKVIRPFLL 1169

  Fly  1581 RRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHI 1645
            ||:|::|.|.:|.|....:.|.||..|..|||||.::          ..:..::.|.||.:   :
  Fly  1170 RRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSR----------AKTRETLQTGNLLS---V 1221

  Fly  1646 FQALRYLQNVCNHPK-------------------------------------------LVLRQSE 1667
            ...|..|:.|||||.                                           |:|...:
  Fly  1222 INVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQ 1286

  Fly  1668 ELTKVTS----------------------------------------QLA--------------- 1677
            .:|...|                                        :||
  Fly  1287 TMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPA 1351

  Fly  1678 --------------------------------------------------------------LSN 1680
                                                                          |||
  Fly  1352 MRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSN 1416

  Fly  1681 SSL-------------------------------------------------------------- 1683
            |.|
  Fly  1417 SKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTA 1481

  Fly  1684 -------------------------------------------DD---------IEHSAKLPALK 1696
                                                       :|         :....:|.|||
  Fly  1482 STTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALK 1546

  Fly  1697 QLLL------------------------------------------------------------- 1700
            ::.:
  Fly  1547 RMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKS 1611

  Fly  1701 ----------------------------------------------------------------- 1700
                                                                             
  Fly  1612 FEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIIS 1676

  Fly  1701 --------------DCGIGVQTE-------SVSQHRALIFCQLKAMLDIVEQDL-LRRHLPSVTY 1743
                          ||| .:||.       .|:.||.|||.|:..|||::|..| ...|:    |
  Fly  1677 EMTTKFPDPRLIQYDCG-KLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHI----Y 1736

  Fly  1744 LRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDR 1808
            ||||||....|||.::..||.|..|...:|:|..||:|:||||||||||.:.||||..|.||.||
  Fly  1737 LRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDR 1801

  Fly  1809 AHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDK 1873
            .|||||.:.|::|||::..::|..|:.....|.:.::..:...|.:.....:|.|.|||...:.:
  Fly  1802 CHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSE 1866

  Fly  1874 GAES------GSSAVQGTASGGMSMNTIIENLPELWS----EHQY---EEEYDLGNFVQALK 1922
            ..||      ....:..|.:...:.:|::|.  |..|    ||..   |:|.|    |||.|
  Fly  1867 QDESSQEKSENKDRIVATTTLSDTPSTVVET--EKQSLRAFEHALAAAEDEQD----VQATK 1922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874	102/609 (17%)
		HEAT repeat	1234..1261	CDD:293787	10/48 (21%)
		HEAT repeat	1269..1298	CDD:293787	11/66 (17%)
		SNF2_N	1353..1662	CDD:278600	107/354 (30%)
		DEXDc	1370..1514	CDD:238005	50/146 (34%)
		Helicase_C	1689..1813	CDD:278689	62/271 (23%)
dom	NP_001286676.1	HSA	543..614	CDD:214727	7/70 (10%)
		ASF1_hist_chap	<674..831	CDD:304562	28/167 (17%)
		FAM176	<824..>868	CDD:291517	7/43 (16%)
		SNF2_N	952..1238	CDD:278600	107/311 (34%)
		DEXDc	969..1108	CDD:238005	50/146 (34%)
		Helicase_C	1692..1806	CDD:278689	57/118 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467174
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930