DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and XNP

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	170/743 - (22%)
Similarity:	277/743 - (37%)	Gaps:	239/743 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1299 LVQLMPLDGKT-EQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISV-------------- 1348
            :::...||..| |..|.:..:.::..||:   .|:|...:.:..|.:...|
  Fly   386 IIKTKDLDLTTKEAAKEEDDRRKRIEDRQ---KLYNRIFVKSESVEINELVLDFDEESKKALLQV 447

  Fly  1349 ------ELRCYQQAGINWLW---------FLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQT 1398
                  :|:.:|.||:.::|         ...|.....||...||||||||.:.:     .|...
  Fly   448 DKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTL-----SHTLL 507

  Fly  1399 ANLANL---PSLVICPPTLTGHW-----------------VYEVEKFLDQGSVLRPLHYYGFPVG 1443
            .|....   ..|:|.|.:...:|                 ||::.::.|:.:.:..|:.: |..|
  Fly   508 VNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEW-FNEG 571

  Fly  1444 ---------------------REKLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHI 1487
                                 |:|.|..:...  ||....|.|               |.||||:
  Fly   572 GVCILGYDMYRILANEKAKGLRKKQREQLMQA--LVDPGPDLV---------------VCDEGHL 619

  Fly  1488 IKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSR 1552
            :||.||..|||:.|::...|::|:|||:|||:.|.:.:..|:.|..|||.|:::.||..||.:.:
  Fly   620 LKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQ 684

  Fly  1553 DAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNK 1617
            ...|:.::..........||:.:...:.||....:...||||....:...||.||.:||..:...
  Fly   685 YTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTT 749

  Fly  1618 HLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEE-------LTKVTSQ 1675
            |        .:.|...:|.:.    ..:||..:.|:.:..|| :.||.:.:       |:...|.
  Fly   750 H--------REQSGGDVVGKG----ARLFQDFQDLRRIWTHP-MNLRVNSDNVIAKRLLSNDDSD 801

  Fly  1676 L------------ALSNSS---------------------------------------------- 1682
            :            |.||||
  Fly   802 MEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGG 866

  Fly  1683 ------------------------LDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLK 1723
                                    |:::.||.||..|.:||..|      |::.. :.|:|.|..
  Fly   867 LGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQC------EAIGD-KLLVFSQSL 924

  Fly  1724 AMLDIVEQDLLRRHLPSVT-------------------------YLRLDGSVPASQRQDIVNNFN 1763
            ..||::|      |..|:.                         |.|||||....||:.:...||
  Fly   925 QSLDVIE------HFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFN 983

  Fly  1764 SDPSI--DVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITR 1826
            :..::  .:.|::|..||||:||..|:.|:..:..|||..|.|::.|.:|.||.|...:||||..
  Fly   984 NITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAM 1048

  Fly  1827 NSLEEKIMGLQKFKILTANTVVSAENAS 1854
            .::|:|:...|..|..||..|:..:..|
  Fly  1049 GTMEQKVYERQVAKQATAKRVIDEQQIS 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	89/358 (25%)
		DEXDc	1370..1514	CDD:238005	45/184 (24%)
		Helicase_C	1689..1813	CDD:278689	43/150 (29%)
XNP	NP_651398.1	DTHCT	258..335	CDD:285332
		SNF2_N	458..779	CDD:278600	87/355 (25%)
		DEXDc	483..646	CDD:238005	45/185 (24%)
		Helicase_C	913..1035	CDD:278689	35/128 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467230
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840