DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and Ino80

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	231/946 - (24%)
Similarity:	348/946 - (36%)	Gaps:	350/946 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1247 ERQGAIEAIERVVSRLQIKVVPYIVL-------LVVPLLGAMSDPDESVRLLSTHCFANLVQLMP 1304
            :|:..:|.||  |.|.|.| :.:::.       .:...||..|:.|: :|:||........:|..
  Fly   401 QRKQDVELIE--VKRQQRK-LNFLITQTELYAHFMSKKLGQGSEEDQ-LRILSQLDEETNARLAA 461

  Fly  1305 LD----GKTEQLKSDPLQARKTRD----REFLDYL-----------------FNPKSIPNYK-VP 1343
            .|    |:.:.|..:..:|...||    |.|..:.                 ..|:..|..| :|
  Fly   462 QDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDVFAKKKEKEEEEQAQESVEDIKPEPRPEMKDLP 526

  Fly  1344 VP--ISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPS 1406
            .|  ....|:.||..|:.||..:....:.|||.|:||||||:|:|..|.....|.....    |.
  Fly   527 QPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVWG----PF 587

  Fly  1407 LVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTK--------CNLVVASYD 1463
            |||.|.:...:|..|:.:|:....|   :.|:|.|..|:.||.....|        .::|:.||.
  Fly   588 LVISPASTLHNWQQEMSRFVPDFKV---VPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQ 649

  Fly  1464 TVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDF 1528
            .|..|..:|:.|.:.|.||||...||:..::..|.:......:||:||||||||::.|||:|..|
  Fly   650 LVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHF 714

  Fly  1529 LMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPP 1593
            :||....:..:|.:.||:.|.|..:.|:...|::     :..||..:.||:|||:|:||..:|..
  Fly   715 IMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQ-----ISRLHMILKPFMLRRIKKDVENELSD 774

  Fly  1594 KITQDLLCELSPLQLRLYEDFSNK-HLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCN 1657
            ||...:.|.|:..|..||.....| .::|.|    ..:|.|..|.:.|:.:::...:...:.|||
  Fly   775 KIEIMVYCPLTIRQKLLYRALKQKIRIEDLL----HLTSGSTTTSSSSSASNLMNLVMQFRKVCN 835

  Fly  1658 HPKLVLR--------------------------------------------QSE----------- 1667
            ||:|..|                                            :||
  Fly   836 HPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVN 900

  Fly  1668 ----------------ELTKVT------------------------------------------- 1673
                            ::.:||
  Fly   901 VNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEPML 965

  Fly  1674 -SQLALS----NSSL---------------------------DDIEH------------------ 1688
             ::|||.    ||.|                           :.|||
  Fly   966 ENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEM 1030

  Fly  1689 -------------------SAK----------LP-----------------ALKQLLLDCGIGVQ 1707
                               :||          ||                 ::.::|.|.|..||
  Fly  1031 EDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQ 1095

  Fly  1708 T----------------------------ESVSQ------------------------------- 1713
            .                            |.||.
  Fly  1096 AVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPDKETLITDAGKLFV 1160

  Fly  1714 ------------HRALIFCQLKAMLDIVEQDLL-RRHLPSVTYLRLDGSVPASQRQDIVNNFNSD 1765
                        ||.||:.|:..|:|::|:.:. |:|    .|:|||||...|.|:|:|.:|.:.
  Fly  1161 LDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKH----RYMRLDGSSKISARRDMVADFQTR 1221

  Fly  1766 PSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLE 1830
            ..|.|.||:|..||||:|||.||||||.:.||||..|.||||||||:||.|.|.|||||.:.::|
  Fly  1222 ADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIE 1286

  Fly  1831 EKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDL 1866
            |:|:...:.|......|:|..|....|:...::..|
  Fly  1287 ERILQRAREKSEIQRMVISGGNFKPDTLKPKEVVSL 1322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787	5/13 (38%)
		HEAT repeat	1269..1298	CDD:293787	7/35 (20%)
		SNF2_N	1353..1662	CDD:278600	104/317 (33%)
		DEXDc	1370..1514	CDD:238005	50/151 (33%)
		Helicase_C	1689..1813	CDD:278689	64/222 (29%)
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	9/39 (23%)
		SNF2_N	538..840	CDD:278600	104/317 (33%)
		DEXDc	555..700	CDD:238005	50/151 (33%)
		Helicase_C	1156..1269	CDD:278689	52/116 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467195
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930