DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and chd1l

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_956607.1	Gene:	chd1l / 393283	ZFINID:	ZDB-GENE-040426-892	Length:	1026	Species:	Danio rerio

Alignment Length:	596	Identity:	183/596 - (30%)
Similarity:	279/596 - (46%)	Gaps:	96/596 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1347 SVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICP 1411
            ::.||.||..|:.||....|.....||.|:||||||.|||.:||    :.:.:...|.|.||:||
Zfish    32 AIHLRPYQLDGVKWLSLCMKNQQGCILGDEMGLGKTCQTISLLA----YARGSLKMNGPFLVLCP 92

  Fly  1412 PTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGT--KCNLVVASYDTVRKDIDFFSG 1474
            ..:..:|..|:|:|....||   :.|.|....|.:|:.::.:  :.::::.:|:...||..:...
Zfish    93 LAVLENWRQELERFCPSLSV---ICYTGDKEKRAELQQNLKSDPRFHVLLTTYEMCLKDARYLKS 154

  Fly  1475 IHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTE-- 1537
            ..:...|:||.|.:||.::...:.:|......|::|:|||||||:.|::||..|:.|.....|
Zfish   155 WKWKILVVDEAHRLKNQESLLHQTLKEFTVGFRVLLTGTPIQNNLQEVYSLLTFIQPSVFLPEAV 219

  Fly  1538 KQFVQRF----SRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQD 1598
            :.||..:    :.|.|                  ::.||:.:.||||||||.:|..:||.|....
Zfish   220 EDFVNAYADIQTEPAL------------------VDELHQVLQPFLLRRVKAEVAAELPKKTELV 266

  Fly  1599 LLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLV- 1662
            :...||.||.|.|:....:.|             .....:.|.||.:...|..|:...:||.|.
Zfish   267 VFHGLSALQKRYYKAILMRDL-------------DAFRTDQSTKTRLLNVLMQLRKCVDHPYLFD 318

  Fly  1663 ------LRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQ 1721
                  ....|.|.:.:.:|:|.:|.|..::...                       |..|:|.|
Zfish   319 GVEPEPFEMGEHLVEASGKLSLLDSMLAYLQEGG-----------------------HHVLLFSQ 360

  Fly  1722 LKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTG 1786
            :..||||::..|..|   ..:|.||||||...:|...:.|| |...:.:.||:|..||:|:|||.
Zfish   361 MTRMLDILQDYLEYR---GYSYERLDGSVRGEERNLAIKNF-STKDVFIFLLSTKAGGVGMNLTA 421

  Fly  1787 ADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAE 1851
            |||||||:.|:||..||||..|||||||.:.|.|.||:.|:::||.|......|:...:||:...
Zfish   422 ADTVIFVDGDFNPQNDLQAAARAHRIGQTRPVKVIRLLGRDTIEEIIYSRAVSKLRLTDTVIEEG 486

  Fly  1852 NASLQTMGTS-----QIFDLFNGGKDKGAESGSSAVQ--------GTASGGMSMNTIIENLPELW 1903
            ..||.....|     |:.::...|.||...|..|:||        |.:..|..:..  |...:|
Zfish   487 RFSLLDQAQSAASGLQLSEILKFGVDKLLSSEESSVQDVDLQLILGQSRDGQWLTD--EEHAKL- 548

  Fly  1904 SEHQYEEEYDL 1914
            :|...||:.|:
Zfish   549 NESNEEEDEDM 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	93/316 (29%)
		DEXDc	1370..1514	CDD:238005	43/145 (30%)
		Helicase_C	1689..1813	CDD:278689	48/123 (39%)
chd1l	NP_956607.1	SNF2_N	38..317	CDD:278600	93/316 (29%)
		DEXDc	54..194	CDD:238005	43/146 (29%)
		DEAH box	163..166		2/2 (100%)
		Helicase_C	335..448	CDD:278689	52/139 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..655
		Required for helicase activity. /evidence=ECO:0000250\|UniProtKB:Q86WJ1	608..666
		Macro_Poa1p_like_SNF2	709..859	CDD:239447
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..929
		BRCT	<951..1014	CDD:294035
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920