Protein Alignment Hel89B and Rad54l2

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001127992.2
• Gene: Rad54l2 / 363135
• RGDID: 1561889
• Length: 1466
• Species: Rattus norvegicus
• Alignment Length: 1058
• Identity: 247/1058 - (23%)
• Similarity: 405/1058 - (38%)
• Gaps: 271/1058 - (25%)

  Fly  1007 SDPEFTPKLVMPLETLKQTPVSSEVI----NNCVYYGIL-TLALQQTVTTTNTRSGAGGATTPTA 1066
            |||:..|.  :.||..::.....||.    :.....|:| ..:|:....|.:.:.|..|...|..
  Rat     9 SDPDLDPD--VELEDAEEEEEEEEVAVEEHDRDDEEGLLDDPSLEGMCGTEHAQLGEDGQRPPRC 71

  Fly  1067 TTAPRGPGRPP-----TGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGE 1126
            |:.......|.     .|:||::.:.      |.::|::....:..|::|.....:|.:.:...:
  Rat    72 TSTTSSQSEPSEQLRHQGKILASEDP------KKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQ 130

  Fly  1127 QIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALH--PQ 1189
            :.:|:..        ::||                           |..|.|||...|.|.  |:
  Rat   131 EELERRK--------RLEQ---------------------------QRKEYAAPIPTVPLEFLPE 160

  Fly  1190 MFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEA 1254
            ...|..|.|     |....|.:|...|.    :|:..             |..::...|...||.
  Rat   161 EIVLRASDG-----PQLPPRVLAQEVIC----LDSSS-------------GSEDEKSSRDEVIEL 203

  Fly  1255 IERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQA 1319
            .......|.|          |....::|:.||......||.                  :|.|..
  Rat   204 SSGEEDTLHI----------VDSSESVSEEDEEEEKGGTHV------------------NDALNQ 240

  Fly  1320 RKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLW---------FLNKYNLHGILCD 1375
            .....|..:: |.:|....|..:...::..::.:|..||.:|:         |........||..
  Rat   241 HDALGRVLVN-LNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAH 304

  Fly  1376 DMGLGKTLQTICILAGDHMHRQTANLANLPS---LVICPPTLTGHWVYEVEKFLDQGSVL----- 1432
            .||||||||.|..:  |.:.|.|      |:   |.|.|.....:|:.|...:|.....|
  Rat   305 SMGLGKTLQVISFI--DVLFRHT------PAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSK 361

  Fly  1433 ----RPLHY--------YGFPVGREKLRSDIGTKCNLVVASYD-----TVRK------------- 1467
                :|..:        :.....|.|:.:|..::..:::..|:     |::|
  Rat   362 PEEIQPRFFKVHILNDEHKTVASRAKVTTDWVSEGGVLLMGYEMYRLLTLKKSLATGRPKKTKKR 426

  Fly  1468 ------DID-------FFSGIHFNYC-------VLDEGHIIKNGKTKSSKAIKRLKANHRLILSG 1512
                  |:|       |........|       :.||||.|||.:..:|:|:|.:::..|::|:|
  Rat   427 SHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTG 491

  Fly  1513 TPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLP 1577
            .|:|||::|.|.:.||:.|.||||.::|...|.||||:.:...|:.::..........||..:..
  Rat   492 YPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEG 556

  Fly  1578 FLLRRVKEDVLK-DLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSA 1641
            |:.|| ...||| .||.|....:|..||.:|..||..|.:: .:||      .||..:....|.|
  Rat   557 FVQRR-GHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDR-FRDC------GSSGWLGLNPLKA 613

  Fly  1642 -------KTH---IFQALRYLQNVCNHPKLVLRQSEEL-------------TKVTSQLALSNSSL 1683
                   ..|   :::||: .:|:.|...|   ..|||             |||..:.:...||:
  Rat   614 FCVCCKIWNHPDVLYEALQ-KENLANEQDL---DVEELGSAGTSTRCPPHGTKVKGEDSALPSSM 674

  Fly  1684 DDIEHSAKLPAL------------------KQLLLDCGIGVQTESVSQ--------------HRA 1716
            .:..:|..|..:                  |.||.:...||...|...              .:.
  Rat   675 GEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKI 739

  Fly  1717 LIFCQLKAMLDIVEQDLLRRHLP---------------SVTYLRLDGSVPASQRQDIVNNFNSDP 1766
            |:|.|..:.|.::|:.|.:|.:|               :|:|.|||||.||.:|:.::|.|| ||
  Rat   740 LVFSQSLSTLALIEEFLGKRDMPCPPGAEGQGAQKWVRNVSYFRLDGSTPAFERERLINQFN-DP 803

  Fly  1767 S---IDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNS 1828
            |   ..:.||:|..|.||:||.||:.|:..:..|||..|.||:.|.:|.||||...:|||:...:
  Rat   804 SNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYT 868

  Fly  1829 LEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMN 1893
            ||:||...|..|...::.||...|..| .....::.:|.:..:.:.|...|..::|.....:.:.
  Rat   869 LEKKIYDRQISKQGMSDRVVDDLNPML-NFTRKEVENLLHFVEKEPAPQTSLDIKGIKESVLQLA 932

  Fly  1894 TIIENLPELWSEHQYEEE 1911
            .:  ..|.|.::..:|.|
  Rat   933 CL--KYPHLITKEPFEHE 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	26/140 (19%)
		HepA	<1342..1849	CDD:440319	174/647 (27%)
Rad54l2	NP_001127992.2	HepA	109..889	CDD:440319	214/886 (24%)
		DEXHc_ARIP4	270..546	CDD:350827	71/283 (25%)
		PHA03247	<1111..1429	CDD:223021