DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and okr

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	173/589 - (29%)
Similarity:	279/589 - (47%)	Gaps:	95/589 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1331 LFNPKSIPNY--------KVPVPISVE------LRCYQQAGINWLWFL---NKYNLHG-ILCDDM 1377
            ||:|.:...:        ||.|.:.|:      ||.:|:.|:.:::..   .:.|.:| |:.|:|
  Fly   123 LFHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEM 187

  Fly  1378 GLGKTLQTICILAGDHMHRQ------TANLANLPSLVICPPTLTGHWVYEVEKFL---------- 1426
            |||||||  |:.....:.||      |.|.|    :|:.|.:|..:|..|..|:|
  Fly   188 GLGKTLQ--CVTLVWTLLRQGPECKPTINKA----IVVSPSSLVKNWEKEFTKWLHGRLLCLPME 246

  Fly  1427 --DQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIK 1489
              .:.:.:|.|..:.....|      :||...|:  ||:|.|...:..........:.||||.:|
  Fly   247 GGTKENTIRALEQFSMTSAR------LGTPVLLI--SYETFRIYAEILCKYEVGMVICDEGHRLK 303

  Fly  1490 NGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDA 1554
            |....:.:|:..||...|::||||||||::.|.:||.:|:.|..|||...|.:.|...||..::.
  Fly   304 NSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNT 368

  Fly  1555 KSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDF----- 1614
            .|:.:|::..:...:.|...|...::||..:.:.|.||.|....:..:|:.:||.||.:|
  Fly   369 DSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQ 433

  Fly  1615 SNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTK-----VTS 1674
            ..:.|.||.:|...::.|.:.|               |:.:|:||.|:.   |:||.     ..|
  Fly   434 VRRSLADCNEKASLTALADITT---------------LKKICSHPDLIY---EKLTAREKGFENS 480

  Fly  1675 QLAL-SNSSLDDIEHSAKLPAL--KQLLLDCGI-GVQTESVSQHRALIFCQLKAMLDIVEQDLLR 1735
            |..| ||....|:.     |.|  |.:|||..: .::.|  ...:.::.......||:.|| |.|
  Fly   481 QNVLPSNYKPKDLN-----PELSGKFMLLDFMLAAIRAE--GNDKVVLISNYTQTLDLFEQ-LAR 537

  Fly  1736 RHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGLNLTGADTVIFVEHDWN 1798
            :.  ...::||||::...:|..:|:.|| ||..|  :.:|::..||.||||.||:.:...:.|||
  Fly   538 KR--KYGFVRLDGTMSIKKRSKVVDRFN-DPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWN 599

  Fly  1799 PMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQI 1863
            |..|.|||.|..|.||||...:|||:...|:||||:..|..|...::|::....::.:......:
  Fly   600 PANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDL 664

  Fly  1864 FDLF 1867
            .|||
  Fly   665 KDLF 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	93/335 (28%)
		DEXDc	1370..1514	CDD:238005	47/162 (29%)
		Helicase_C	1689..1813	CDD:278689	43/128 (34%)
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	93/335 (28%)
		DEXDc	179..328	CDD:238005	47/162 (29%)
		HELICc	493..622	CDD:238034	47/139 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467233
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840