Protein Alignment Hel89B and Chd7

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001264078.1
• Gene: Chd7 / 320790
• MGIID: 2444748
• Length: 2986
• Species: Mus musculus
• Alignment Length: 674
• Identity: 200/674 - (29%)
• Similarity: 309/674 - (45%)
• Gaps: 125/674 - (18%)

  Fly  1301 QLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLN 1365
            :||..:.:||:::..|....| :.....:|..|.|              ||.||..|:|||.| |
Mouse   924 KLMSREPETERVERPPADDWK-KSESSREYKNNNK--------------LREYQLEGVNWLLF-N 972

  Fly  1366 KYNLHG-ILCDDMGLGKTLQTICI-----LAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEK 1424
            .||:.. ||.|:||||||:|:|..     |.|.|.          |.|||.|.:...:|..|...
Mouse   973 WYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHG----------PFLVIAPLSTIPNWEREFRT 1027

  Fly  1425 FLDQGSVLRPLHYYGFPVGREKL------------RSDIGT-KCNLVVASYDTVRKDIDFFSGIH 1476
            :.:...|:    |:|....|..:            |...|: |.:.::.:::.:..|......|.
Mouse  1028 WTELNVVV----YHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIP 1088

  Fly  1477 FNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFV 1541
            :...|:||.|.:||...|..:.:|.:...|:::|:|||:||.|.||:||..||.|....:|..|:
Mouse  1089 WRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFM 1153

  Fly  1542 QRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPL 1606
            |.|.       |.|:..:.|:     ::|:   :.|.:|||:||||.|:|.||....:..||:.:
Mouse  1154 QEFG-------DLKTEEQVQK-----LQAI---LKPMMLRRLKEDVEKNLAPKEETIIEVELTNI 1203

  Fly  1607 QLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTK 1671
            |.:.|.....|:. ..|.|.|..::.          .::...:..|:..||||.|:....|::.:
Mouse  1204 QKKYYRAILEKNF-TFLSKGGGQANV----------PNLLNTMMELRKCCNHPYLINGAEEKILE 1257

  Fly  1672 VTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRR 1736
            ...:  ..|:...|.:..|.:.|..:|:|...: :.......||.|||.|:...|||:|..|::|
Mouse  1258 EFKE--THNAESPDFQLQAMIQAAGKLVLIDKL-LPKLKAGGHRVLIFSQMVRCLDILEDYLIQR 1319

  Fly  1737 HLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGLNLTGADTVIFVEHDWNP 1799
            ..|   |.|:||.|..:.||..::.| |.|..|  |.||.|..||||:|||.|||.|..:.||||
Mouse  1320 RYP---YERIDGRVRGNLRQAAIDRF-SKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNP 1380

  Fly  1800 MKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSA----ENAS--LQTM 1858
            ..||||..|.|||||.|.|.:||||||||.|.::......|:.....|:.:    |||:  :|.:
Mouse  1381 QNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQL 1445

  Fly  1859 GTSQIFDLFNGG--------KDKGAE-----------------------SGSSAVQGT--ASGGM 1890
            ...:|.||...|        :|:|::                       .||:..:.:  |||..
Mouse  1446 SKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNR 1510

  Fly  1891 SMNTIIENLPELWSEHQYEEEYDL 1914
            :..::.:  |..|.:...:.|.|:
Mouse  1511 TDISLDD--PNFWQKWAKKAELDI 1532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	172/527 (33%)
Chd7	NP_001264078.1	Glutenin_hmw	<23..553	CDD:367362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..792
		CD1_tandem_CHD5-9_like	786..850	CDD:349315
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..949		4/21 (19%)
		PLN03142	957..>1556	CDD:215601	192/640 (30%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:462196
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2924..2986