Protein Alignment Hel89B and Smarca1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001258119.1
• Gene: Smarca1 / 317575
• RGDID: 1561046
• Length: 1062
• Species: Rattus norvegicus
• Alignment Length: 779
• Identity: 235/779 - (30%)
• Similarity: 350/779 - (44%)
• Gaps: 135/779 - (17%)

  Fly  1217 AVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAI---------ERVVSRLQIKVV----- 1267
            |.:|..||..|: .|:.|..|.....::......|.||.         |::.|..|:|:.
  Rat    10 ATVAASDARATI-VVLEDEQPGPSTFKEEGAAAAATEATTATEKGEKKEKITSPFQLKLAAKTSK 73

  Fly  1268 -------PYIVLLV-VPLLGAMSDPDESVR----LLSTHCFANLVQ-------LMPLDGK--TEQ 1311
                   .|...:| :||     ..|.:.|    |..|..||:.:|       ..||:.|  ..:
  Rat    74 SEKEMDPEYEEKMVNIPL-----KADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLARPR 133

  Fly  1312 LKSDPLQA---------RKTRDREFLDYLFNPKSIPNYKVPVPISVE------LRCYQQAGINWL 1361
            :|.|..|:         |:|...|..:.|...:...|..|...:|..      ||.||..|:|||
  Rat   134 VKKDDKQSLISVGDYRHRRTEQEEDEELLSESRKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWL 198

  Fly  1362 WFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFL 1426
            ..|.:..::|||.|:||||||||||.:|.....:|....    |.:|:.|.:...:|:.|.::::
  Rat   199 ISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNFPG----PHMVLVPKSTLHNWMNEFKRWV 259

  Fly  1427 DQGSVLRPLHYYGFPVGREKLRSD--IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIK 1489
            ..   ||.:.:.|....|.....|  :..:.::.|.||:.|.|:...|...|:.|.|:||.|.||
  Rat   260 PS---LRVICFVGDKDVRAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIK 321

  Fly  1490 NGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDA 1554
            |.|:|.|:.::..|:.:||:|:|||:|||:.|||:|.:||:|....:...|...|        |.
  Rat   322 NEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DT 378

  Fly  1555 KSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHL 1619
            |:...:|:    .:|.||..:.||||||:|.||.|.||||....:...||.:|...|    .|.|
  Rat   379 KNCLGDQK----LVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWY----TKIL 435

  Fly  1620 KDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLD 1684
            ...:|.|..|....        |..:...|..|:..||||.|...........|.:..:||
  Rat   436 MKDIDVLNSSGKMD--------KMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSN---- 488

  Fly  1685 DIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGS 1749
                |.|:.||.:||    ..::.:.   .|.|||.|:..:|||:|...:.|   ...|.||||.
  Rat   489 ----SGKMVALDKLL----ARIKEQG---SRVLIFSQMTRLLDILEDYCMWR---GYEYCRLDGQ 539

  Fly  1750 VPASQRQDIVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIG 1813
            .|..:|::.:..||: :.|..:.:|:|..||||:||..||.||..:.||||..||||||||||||
  Rat   540 TPHEEREEAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIG 604

  Fly  1814 QKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVS------------AENASLQTM--GTSQIF 1864
            |||.|.|:||||.|::||:|:...:.|:...:.|:.            |:...||.:  |.:.:|
  Rat   605 QKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVF 669

  Fly  1865 -------------DLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDLG 1915
                         .:...|:.|.||......:...|...:....:|.....:....|.|:..||
  Rat   670 ACKESELTDEDIVTILERGEKKTAEMNERMQKMGESSLRNFRMDLEQSLYKFEGEDYREKQKLG 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	183/515 (36%)
Smarca1	NP_001258119.1	PLN03142	64..1061	CDD:215601	222/724 (31%)