Protein Alignment Hel89B and Smarcal1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001101692.1
• Gene: Smarcal1 / 316477
• RGDID: 1306134
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 1101
• Identity: 248/1101 - (22%)
• Similarity: 423/1101 - (38%)
• Gaps: 292/1101 - (26%)

  Fly   906 LDMLEERRRSLQASYQQTTSE--QSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQC 968
            |.:.||:|:.::.:.|:..:.  :..:....|:..:|:..|                   :..||
  Rat     3 LPLTEEQRKKIEENRQKALARRAEKLWAEQPQSTASGSSAA-------------------RPSQC 48

  Fly   969 LQ--LQQLSAEFLVHLMDQVCDRNPSPNSKI-----LNNLCTLLR---SDPEFTPKLVMPLETLK 1023
            .|  |..|.||          ...|..::.|     |||.....:   |.|.|.|......:.|.
  Rat    49 KQNSLLNLPAE----------PSKPEGHATISKGQNLNNSLPAAQRPHSSPCFQPSTAEEAKGLW 103

  Fly  1024 QT----------PVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPR------- 1071
            ::          |...||.|             |.:..:.:..|...||..||.:.||
  Rat   104 KSEGKMSAACPNPSPPEVSN-------------QQLLGSKSSEGHPQATQDTAASCPRPFPRDPK 155

  Fly  1072 ---GPGRPPT-GEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKV 1132
               ..|||.| |:.:|.|......:......:.|:|.|...|:  |:| :..:|...|::...|:
  Rat   156 LEAKAGRPSTSGQSISDTFYALGEKTPKTDGRPAKALQTSPQK--ASC-LRGMCLRTGDRFRVKI 217

  Fly  1133 A-------VFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALHP-- 1188
            .       ||:.|...:.:.|.| .:|:.:...       ..|:.:::.:.|      |:|.|
  Rat   218 GYNKELIEVFKSLPSRRYDSFTK-TWDFSMSDY-------RALMKAVERLST------VSLQPLE 268

  Fly  1189 --------QMFALLPSLGFIVCHPLKAVRHMAARCIAV----------LAEIDACQTMQFVVHDL 1235
                    ......|||.|:           ..||:.:          .:|:......|....:.
  Rat   269 EVDGTGGQTSLPSAPSLTFV-----------TGRCMLISRARFEVDIGYSEVVIALFKQMESRNY 322

  Fly  1236 LPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLV 1300
            .|...|...|:|....:.|..|.:.::|:..:|..:.|                     .||:.:
  Rat   323 DPKTRKWNFLLEEHNKLIARSRELKQVQLDPLPKTLTL---------------------AFASQL 366

  Fly  1301 QLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLN 1365
            :...|     |.|:|..:|    |...:|    .|.:.|          |..:|:.|:::.  ::
  Rat   367 EKTSL-----QSKADVPEA----DLSGVD----AKLVSN----------LMPFQREGVSFA--IS 406

  Fly  1366 KYNLHG--ILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQ 1428
            |   .|  :|.||||||||:|.|||.|   .:|:     ..|.||:.|.::...|   .:.||..
  Rat   407 K---RGRLLLADDMGLGKTIQAICIAA---FYRK-----EWPLLVVVPSSVRFTW---EQAFLRW 457

  Fly  1429 GSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKT 1493
            ...|.|........|:.:|.:.:   .|:|  |:|.:.| ::......|...::||.|.:||.||
  Rat   458 LPSLSPEDINVVVTGKGRLTAGL---VNIV--SFDLLSK-LEKQLKTPFKVVIIDESHFLKNIKT 516

  Fly  1494 -KSSKAIKRLKANHRLI-LSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRF--SRPILSSRDA 1554
             :...|:..||...|:| |||||..:...||::....:.|.|......|..|:  ::.:....|.
  Rat   517 ARCRAAVPILKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRLPWGWDY 581

  Fly  1555 KSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHL 1619
            ..|:...|..:|..||:       :|||:|.|||..||.|  |..:..::|.::       :...
  Rat   582 SGSSNLGELKLLLEEAV-------MLRRLKSDVLSQLPAK--QRKMVVVNPGRI-------STRA 630

  Fly  1620 KDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLD 1684
            |..||     ::|..:|::                     |...:|.|.|      |...|.:.:
  Rat   631 KAALD-----AAAKEMTKD---------------------KTKQQQKEAL------LVFFNRTAE 663

  Fly  1685 DIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGS 1749
                 ||:|.:.:.:||.     .|| .:.:.|:|...|.:||.:.::|.|:   :|.::|:|||
  Rat   664 -----AKIPCVIEYILDL-----LES-GREKFLVFAHHKVLLDAIAKELERK---NVQHIRIDGS 714

  Fly  1750 VPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQ 1814
            .|::.|:|:...|.......|.:|:.....:||..:.||.|:|.|..|||...:||.||.|||||
  Rat   715 TPSADREDLCQQFQLSKGHTVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQ 779

  Fly  1815 KKVVNVYRLITRNSLEEKIMGL--QKFKILTANTVVSAENASLQTMGT---------SQIFDLF- 1867
            ...|.::.|:.:.:.::.:..|  :|.|:| ....:|..|.|..|..|         ..|:.||
  Rat   780 TNSVGIHYLVAKGTADDYLWPLIQEKIKVL-GEAGLSETNFSEMTEATDYLYKDPKQKTIYSLFQ 843

  Fly  1868 ----NGGKDK-----------GAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYD 1913
                :.|.|.           |:.||:|.......|.::....:.:.|......::.:.:|
  Rat   844 QSFEDDGNDMEFLEAAESFELGSTSGTSGNSSQELGDITDENALADSPPKKRRFEFFDNWD 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	55/271 (20%)
		HepA	<1342..1849	CDD:440319	139/514 (27%)
Smarcal1	NP_001101692.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..170		42/208 (20%)
		Mediates interaction with RPA2. /evidence=ECO:0000250	2..30		5/26 (19%)
		Mediates interaction with RPA2. /evidence=ECO:0000250|UniProtKB:Q9NZC9	5..30		4/24 (17%)
		HARP	213..267	CDD:462166	11/67 (16%)
		HepA	<323..807	CDD:440319	157/611 (26%)
		DEXHc_HARP_SMARCAL1	393..602	CDD:350768	67/237 (28%)
		DESH box	506..509		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	601..618		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..890		5/24 (21%)