DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and Smarcad1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	XP_038963492.1	Gene:	Smarcad1 / 312398	RGDID:	1309640	Length:	1033	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	262/959 - (27%)
Similarity:	410/959 - (42%)	Gaps:	219/959 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1019 LETLKQT-PVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEIL 1082
            |:|||:. |..|:            ..|.:.:.:|:|..||..|.......|..||.:   .::.
  Rat   161 LQTLKELFPQRSD------------SDLLKLIDSTSTMDGAIAAALLKFGDAGGGPRK---RKLS 210

  Fly  1083 SATNATAHIELKAQQA-------------KEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAV 1134
            |::.|....|....|:             :.|||.....::......::|....|.:|.:.:|
  Rat   211 SSSEAYEEDEANDDQSLKKPRGDRREESNESAEASSNWEKQESIVLKLQKEFPNFDKQELREV-- 273

  Fly  1135 FQHLMFGKVEQFVKEAYDWRLGSLLPDLGV--------C---------NELVSSMQLIETAAPHL 1182
                        :|| ::|.....|..|.|        |         .|:..:....:.||.
  Rat   274 ------------LKE-HEWMYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNAAK-- 323

  Fly  1183 HVALHPQMFALLPSLGF------IVCHPLKAVRHMAARCIAVLAEID--------------ACQT 1227
              ....|..::.|..||      .|.:|.|||..         :|.|              :|:.
  Rat   324 --IKMKQKISMKPQNGFNKKRKKNVFNPKKAVED---------SEYDSGSDAGSSLDEDYSSCEE 377

  Fly  1228 MQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLS 1292
               |:.|  ...|||...::.....|                  |.::|    .....::.:::.
  Rat   378 ---VMED--GYKGKILHFLQDASIGE------------------LTLIP----KCSQKKAQKIIE 415

  Fly  1293 THCFANLVQLMPLDGKTEQLKSDPLQARKT--RDREFLDYLFNP-KSIPN--------------- 1339
            ...|.|...|.....|...|..|.:...||  ::|:.:..|.|. :.|.|
  Rat   416 LRPFNNWETLFTKMSKINGLSEDLIWNCKTVIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGG 480

  Fly  1340 YKVPVPI----SVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTAN 1400
            :.:..|.    |:.|:.||:.|:|||..::|:.|:|||.|:||||||:|.|..||  ::. |..|
  Rat   481 WNIEQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLA--YLF-QEGN 542

  Fly  1401 LANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTK---CNLVVASY 1462
            ..  |.|::.|.:...:|:.||..:.   ..|..|.|||....|:::|.:|..|   .|::|.:|
  Rat   543 KG--PHLIVVPASTIDNWLREVNLWC---PTLNVLCYYGSQEERKQIRFNIHNKYEDYNVIVTTY 602

  Fly  1463 D---TVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWS 1524
            :   :...|...|..:..||.:.||||::||..:...:.:..:.|.:||:|:|||:|||:|||.|
  Rat   603 NCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMS 667

  Fly  1525 LFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVL-PFLLRRVKEDVL 1588
            |.:|:||....:....::|    :.||:  ...|.||........|..:|:: ||:||||||:||
  Rat   668 LLNFVMPHMFSSSTSEIRR----MFSSK--TKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVL 726

  Fly  1589 KDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQ 1653
            |.||||..|..||.:|..|.:||....|: ||..::             ||...|.:...:..|:
  Rat   727 KLLPPKKDQIELCAMSEKQEQLYSGLFNR-LKKSIN-------------NLEKNTEMCNVMMQLR 777

  Fly  1654 NVCNHPKLVLRQ--SEELTKVTSQLAL-------SNSSL--DDIE---------------HSAKL 1692
            .:.||| |:.||  :.|..|..|||.|       :|..|  :|:|               |....
  Rat   778 KMANHP-LLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSY 841

  Fly  1693 PALKQLLLDCG----IGVQTESVSQ--HRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVP 1751
            .....|:||.|    :|.....:.|  .|.::|.|...||||:|. ||:.|  ...||||||...
  Rat   842 QLDMDLILDSGKFRTLGCILSELKQKGDRVVLFSQFTMMLDILEV-LLKHH--QHRYLRLDGKTQ 903

  Fly  1752 ASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKK 1816
            .|:|..:::.||:|..|.|.||:|..||||:|||.|:.||..:.|.||..|.||.||.||:||.|
  Rat   904 ISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTK 968

  Fly  1817 VVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFD 1865
            .|.|.:||::.::||.::.:.:.|:.....:.:.:..     |.|.:.|
  Rat   969 EVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEG-----GHSDLLD 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874	26/132 (20%)
		HEAT repeat	1234..1261	CDD:293787	5/26 (19%)
		HEAT repeat	1269..1298	CDD:293787	3/28 (11%)
		SNF2_N	1353..1662	CDD:278600	110/315 (35%)
		DEXDc	1370..1514	CDD:238005	49/149 (33%)
		Helicase_C	1689..1813	CDD:278689	53/129 (41%)
Smarcad1	XP_038963492.1	MSCRAMM_ClfB	<18..247	CDD:411414	22/100 (22%)
		PLN03142	474..>996	CDD:215601	190/553 (34%)
		DEXHc_SMARCAD1	495..677	CDD:350756	71/189 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920