DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and Chd1l

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	XP_006233080.1	Gene:	Chd1l / 310707	RGDID:	1311935	Length:	926	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	191/640 - (29%)
Similarity:	289/640 - (45%)	Gaps:	131/640 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1317 LQARKTRDREFLDYLFNPKSIPNYKVPVPI---------------SVELRCYQQAGINWLWFLNK 1366
            |||.:..||                 |.|:               .:.||.||..|:|||    .
  Rat    40 LQALRAGDR-----------------PEPVRTRVQEQDLQEWGLTGIRLRSYQLEGVNWL----V 83

  Fly  1367 YNLHG----ILCDDMGLGKTLQTICIL------AGDHMHRQTANLANLPSLVICPPTLTGHWVYE 1421
            ...||    ||.|:||||||.|||.:|      ..|..          |.|::||.::..:|..|
  Rat    84 QCFHGQNGCILGDEMGLGKTCQTIALLIYLVGRLNDEG----------PFLILCPLSVLSNWKEE 138

  Fly  1422 VEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKC--NLVVASYDTVRKDIDFFSGIHFNYCVLDE 1484
            :|:|   ...|..:.|.|....|.:.:.|:..:.  ::::.:|:...||..|.....::...:||
  Rat   139 MERF---APGLSCVTYTGDKEERARRQQDLRQESGFHVLLTTYEICLKDASFLKSFSWSVLAVDE 200

  Fly  1485 GHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTE--KQFVQRFSRP 1547
            .|.:||..:...:.:.......||:|:||||||::.||:||...:.|.....|  :.|||.:..
  Rat   201 AHRLKNQSSLLHRTLSEFSVVFRLLLTGTPIQNSLQELYSLLSVVEPDLFCREQVEDFVQCYQD- 264

  Fly  1548 ILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYE 1612
              ..:::||:::           |||.:.||||||||..|..:||.|....:...:|.||.:.|:
  Rat   265 --IEKESKSASE-----------LHRLLRPFLLRRVKAQVATELPKKTEVVIYHGMSALQKKYYK 316

  Fly  1613 DFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLA 1677
            ...   :|| ||...:.::..:..:|:         |..|:...:||.|......|..:|...|
  Rat   317 AIL---MKD-LDAFENETAKKVKLQNV---------LTQLRKCVDHPYLFDGVEPEPFEVGEHL- 367

  Fly  1678 LSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVT 1742
                    ||.|.||..|.:||.....|       .||.|:|.|:..||||::..:..|   ..:
  Rat   368 --------IEASGKLHLLDRLLAFLYSG-------GHRVLLFSQMTHMLDILQDYMDYR---GYS 414

  Fly  1743 YLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMD 1807
            |.|:||||...:|...:.||...| |.|.||:|..||:|:|||.|||||||:.|:||..||||..
  Rat   415 YERVDGSVRGEERHLAIKNFGKQP-IFVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAA 478

  Fly  1808 RAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTS-----QIFDLF 1867
            |||||||.|.|.|.|||.|:::||.:......|:...|.|:...:.:|.....:     |:.::.
  Rat   479 RAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMVIEGGHFTLGAQKPAAEADLQLSEIL 543

  Fly  1868 NGGKDKGAESGSSAVQGTASGGMSMNTII-ENLPELWS----------EHQYEEE 1911
            ..|.||...|     :|::...:.:.:|: |.....|:          |.:.:||
  Rat   544 KFGLDKLLSS-----EGSSMDEIDLKSILGETKDGQWTPDALPAAAEGESREQEE 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	92/322 (29%)
		DEXDc	1370..1514	CDD:238005	42/155 (27%)
		Helicase_C	1689..1813	CDD:278689	56/123 (46%)
Chd1l	XP_006233080.1	SNF2_N	74..353	CDD:278600	92/322 (29%)
		DEXDc	90..230	CDD:238005	40/152 (26%)
		Helicase_C	371..484	CDD:278689	56/123 (46%)
		Macro	745..895	CDD:294024
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010