Protein Alignment Hel89B and Chd2

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_063118674.1
• Gene: Chd2 / 308738
• RGDID: 1310056
• Length: 1840
• Species: Rattus norvegicus
• Alignment Length: 1098
• Identity: 288/1098 - (26%)
• Similarity: 436/1098 - (39%)
• Gaps: 304/1098 - (27%)

  Fly   911 ERRRSLQASYQQTTSEQSAYHVSAQAALA--GAICALHCLPDKL--NPVVK--PLMESIKREQCL 969
            :|:...|..::|..||......|:..:.|  ..:.|...:|.:.  .|.||  |.::..||::
  Rat   155 QRQLKKQEKWKQDPSEDDQEQGSSAESEAEQKKVKARRPIPRRTVPKPQVKKQPKIQRGKRKK-- 217

  Fly   970 QLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPK----LVMPLETLKQTPVSSE 1030
              |:.|.:      |...|..|...::.........:.|.:|...    :.|..|.:.:...:||
  Rat   218 --QESSDD------DDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSE 274

  Fly  1031 VINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATT-APRGPGRP--------PTGEI----- 1081
            .|...:                ::|.|..|||..:.|. |....|.|        ..|||
  Rat   275 TIEKVL----------------DSRLGKKGATGASTTVYAVEANGDPSGDFDTEREEGEIQYLIK 323

  Fly  1082 ---LSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKV 1143
               .|..::|...|...||.|....|                                     |:
  Rat   324 WKGWSYIHSTWESEESLQQQKVKGLK-------------------------------------KL 351

  Fly  1144 EQFVK---EAYDWRLGSLLPD--------LGVCNELVSSMQLIETAAPHLHVALHPQMFALLPSL 1197
            |.|.|   |...| ||.:.|:        ..:.:||....|::|
  Rat   352 ENFKKKEDEIKQW-LGKVSPEDVEYFNCQQELASELNKQYQIVE--------------------- 394

  Fly  1198 GFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPL-LGKIEQLIERQGAIEAIERVVSR 1261
                            |.|||.....|.....|..|...|. ..:.|.|.:..|
  Rat   395 ----------------RVIAVKTSKSALGQTDFPAHSRKPAPSNEPEYLCKWMG----------- 432

  Fly  1262 LQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQARK----- 1321
                 :||         ...|..||:                 |.||..|...|...:|.
  Rat   433 -----LPY---------SECSWEDEA-----------------LIGKKFQSCIDSFHSRNNSKTI 466

  Fly  1322 -TRDREFLDYLFNPKSIPNYKVPVPI---SVELRCYQQAGINWL---WFLNKYNLHGILCDDMGL 1379
             ||:.:.|..  .|:.:...|.|..:   ::|||.||..|:|||   |.  |.| ..||.|:|||
  Rat   467 PTRECKALKQ--RPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWC--KSN-SVILADEMGL 526

  Fly  1380 GKTLQTICILAG-DHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVG 1443
            |||:|||..|:. .|.|:...     |.|::.|.:....|..|.|.:..:.:|   :.|.|..:.
  Rat   527 GKTIQTISFLSYLFHQHQLYG-----PFLIVVPLSTLTSWQREFEIWAPEVNV---VVYIGDLMS 583

  Fly  1444 REKLR-------SDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKR 1501
            |..:|       .....|.|.::.:|:.:.||......|::.:..:||.|.:||..:...|.:..
  Rat   584 RNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLID 648

  Fly  1502 LKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEK-QFVQRFSRPILSSRDAKSSAKEQEAGV 1565
            .|:||||:::|||:||::.|||||..|:||     || :|.:.|.         :...|.:|.|
  Rat   649 FKSNHRLLITGTPLQNSLKELWSLLHFIMP-----EKFEFWEDFE---------EDHGKGRENG- 698

  Fly  1566 LAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSS 1630
              .::||:.:.||||||||:||.|.||.|:.|.|..|:|.||.:.|:....::.|........|:
  Rat   699 --YQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKALAKGTRGST 761

  Fly  1631 SA--SMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLP 1693
            |.  ::|.|              |:..|||..|: |..|:..:.|.|..|.:.    |..|.||.
  Rat   762 SGFLNIVME--------------LKKCCNHCYLI-RAPEDSERETGQEVLQSL----IRSSGKLI 807

  Fly  1694 ALKQLLL---DCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQR 1755
            .|.:||.   :.|          :|.|||.|:..||||:.:.|..:|.|   :.|||||:....|
  Rat   808 LLDKLLTRLRERG----------NRVLIFSQMVRMLDILAEYLTIKHYP---FQRLDGSIKGEIR 859

  Fly  1756 QDIVNNFNSDPSID-VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVN 1819
            :..:::||:|.|.| ..||:|..||||:||..||||:..:.||||..||||..|||||||||.||
  Rat   860 KQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVN 924

  Fly  1820 VYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDK----------- 1873
            :|||:|:.::||:|:...|.|::..:.|:.    .:.|.|.:.:.:  |.|:..
  Rat   925 IYRLVTKGTVEEEIIERAKKKMVLDHLVIQ----RMDTTGRTVLEN--NSGRSNSNPFNKEELTA 983

  Fly  1874 ----GAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYE----------EEYDLGNF 1917
                |||.....::|..|....|:  |:.:..|....:.|          .::.:.||
  Rat   984 ILKFGAEDLFKEIEGEESEPQEMD--IDEILRLAETRENEVSTSATDELLSQFKVANF 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	46/253 (18%)
		HepA	<1342..1849	CDD:440319	187/527 (35%)
Chd2	XP_063118674.1	None