Protein Alignment Hel89B and Hltf

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001426368.1
• Gene: Hltf / 295568
• RGDID: 1309031
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 821
• Identity: 176/821 - (21%)
• Similarity: 290/821 - (35%)
• Gaps: 330/821 - (40%)

  Fly  1309 TEQLKSDPLQARKTRDREFLDYLFNPKSI---PNYKVPVPISVELRCYQQAGINWL--------- 1361
            |||||::       .|:.|.|...:.::|   |...|..|    |..:|:..:.|:
  Rat   207 TEQLKTE-------FDKLFEDLKEDDRTIEMEPAEAVETP----LLPHQKQALAWMIARENSKEL 260

  Fly  1362 ---WFLNK----------------YNLH-GILCDDMGLGKTLQTICI------------------ 1388
               |.|..                .|:| |||.|||||||||..|.:
  Rat   261 PPFWELRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVILTNFDDGRPLLGKRGKE 325

  Fly  1389 -------------LAGDHMHRQT---------------------ANLANL--------------- 1404
                         |.|.:.::.|                     :|:::|
  Rat   326 SHPGKEYKDETVKLRGSNTNKTTDGHSEPSACSEEPSISDVSEKSNVSDLFSFFSKRRKISVQST 390

  Fly  1405 ----------------------------------------------------------------- 1404
                                                                             
  Rat   391 ESSESEEIETSKLSQKMKGKLKNTQLDTKSKVKGSSKIKEDTQFALALTYFGPATKKKMLKKGTS 455

  Fly  1405 ---------------PSLVICPPTLTGHWV--------YEVEKFLDQ-GSVLR---PLHYYGFPV 1442
                           .:|:|||.::..:|:        :.::...|| |..::   .|:.|.: .
  Rat   456 VMESSKKCDTGERTRTTLIICPLSVLSNWILFSLISLRFFMKYTQDQIGQHIKSEVDLNLYVY-Y 519

  Fly  1443 GREKLRSD--------IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAI 1499
            |.:::|..        |.|..|::...|.|  ||......|.:...:|||||.|:|...:.:||:
  Rat   520 GPDRIRDSTWLSKQDIILTTYNILTHDYGT--KDNSPLHSIKWLRVILDEGHAIRNPNAQQTKAV 582

  Fly  1500 KRLKANHRLILSGTPIQNNVLELWSLFDFL-MPGFLGTEKQFVQR-FSRPILSSRDAKSSAKEQE 1562
            ..|:|..|.:|:||||||::.:||||..|| :..|  |::::..| ..||:.:.         .|
  Rat   583 LELEAERRWVLTGTPIQNSLKDLWSLLSFLKLKPF--TDREWWHRIIQRPVTTG---------DE 636

  Fly  1563 AGVLAMEALHRQVLPFLLRRVKEDVLK-----DLPPKITQDLLCELSPLQLRLYEDFSNKHLKDC 1622
            .|:..:::|.:.:   .|||.|...:|     :||.:........||..:.::|:...|:
  Rat   637 GGLRRLQSLIKSI---TLRRTKTSKIKGKPVLELPERKVFIQHITLSVEERKIYQSVKNE----- 693

  Fly  1623 LDKLGDSSSASMVTEN--LSAKTHIFQALRYLQNVCNHPKLVLRQS-----------EELTK--V 1672
                |.::.|...||.  |:....:...|..|:.:|.|..|....:           |||.|  |
  Rat   694 ----GKATIARYFTEGTVLAHYADVLGLLLRLRQICCHVHLPTNGTSSSDPSRSDTPEELRKMLV 754

  Fly  1673 TS-QLALSNSS-------LDD-----IEHSAKL---PALKQL---------------------LL 1700
            |. :|.||:.|       ||.     |.|.|.:   |.:.|:                     ||
  Rat   755 TKMKLILSSGSDEECSICLDSLTFPVITHCAHVFCKPCICQVIQREQPHAKCPLCRSNIHGHNLL 819

  Fly  1701 DCG-----------------------------IGVQTESVSQHRALIFCQLKAMLDIVEQDLLRR 1736
            :|.                             |.::|:. ...::|:..|....|.::|..|
  Rat   820 ECPPEELACDSDNKSDMEWTSSSKINALMNALIELRTKD-PNIKSLVVSQFTTFLSLIETPL--- 880

  Fly  1737 HLPSVTYLRLDGSVPASQRQDIVNNF-NSDP-SIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNP 1799
            ......:.|||||:...:|.:.:..| |:|. |..::||:...||:||||..|..|..::..|||
  Rat   881 KASGFVFTRLDGSMAQKKRVESIQCFQNTDAGSPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNP 945

  Fly  1800 MKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFK 1840
            ..:.|..||.||:|||:.|.:.:.|.::|:||.::.:|..|
  Rat   946 AAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNMK 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	166/785 (21%)
Hltf	NP_001426368.1	None