Protein Alignment Hel89B and Chd5

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_006538992.1
• Gene: Chd5 / 269610
• MGIID: 3036258
• Length: 1955
• Species: Mus musculus
• Alignment Length: 711
• Identity: 201/711 - (28%)
• Similarity: 324/711 - (45%)
• Gaps: 109/711 - (15%)

  Fly  1237 PLLGKIEQLIERQGAIE---AIERVVSR-----------LQIKVVPY------IVLLVVPLLGAM 1281
            ||..|:|:...|.|...   .:.|:::.           ::.|.:||      |..:.:|....:
Mouse   575 PLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNL 639

  Fly  1282 SDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPI 1346
            .......|.|.....|.|.:.:...||  :||.|  :..|..|...:|     .::...|.|..|
Mouse   640 KQAYWGHRELMLGEDARLPKRLVKKGK--KLKDD--KQEKPPDTPIVD-----PTVKFDKQPWYI 695

  Fly  1347 SV---ELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLV 1408
            ..   .|..||..|:|||.|........||.|:||||||:|||..|...:....:..    |.||
Mouse   696 DATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKG----PYLV 756

  Fly  1409 ICPPTLTGHWVYEVEKFL------------DQGSVLRPLHYYGFP-----VGRE--KLRSDIGTK 1454
            ..|.:...:|..|.|.:.            :..||:|. :.:.|.     .|::  :::.::..|
Mouse   757 SAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRE-NEFSFEDNAIRGGKKVFRMKKEVQIK 820

  Fly  1455 CNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNV 1519
            .::::.||:.:..|......|.:...|:||.|.:||.::|..:.:...|.:::|:|:|||:|||:
Mouse   821 FHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNL 885

  Fly  1520 LELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVK 1584
            .||:.|.:||.|......:.|::.|:          ..:||.:     ::.||..:.|.:|||:|
Mouse   886 EELFHLLNFLTPERFNNLEGFLEEFA----------DISKEDQ-----IKKLHDLLGPHMLRRLK 935

  Fly  1585 EDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQAL 1649
            .||.|::|.|....:..|||.:|.:.|:....::. :.|:..|..:..|::           ..:
Mouse   936 ADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNF-EALNSKGGGNQVSLL-----------NIM 988

  Fly  1650 RYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDD---IEHSAKLPALKQLLLDCGIGVQTESV 1711
            ..|:..||||.|....:.|..      .|.|.|.|.   ::.|.||..|:::|..    ::.|.
Mouse   989 MDLKKCCNHPYLFPVAAVEAP------VLPNGSYDGSSLVKSSGKLMLLQKMLKK----LRDEG- 1042

  Fly  1712 SQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLT 1774
              ||.|||.|:..|||::|..|   ......|.|:||.:....||:.::.||: |...  ..||:
Mouse  1043 --HRVLIFSQMTKMLDLLEDFL---EYEGYKYERIDGGITGGLRQEAIDRFNA-PGAQQFCFLLS 1101

  Fly  1775 TMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKF 1839
            |..||||:||..|||||..:.||||..|:||..|||||||.|.|.:||.:||.|:||:|..:.|.
Mouse  1102 TRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKR 1166

  Fly  1840 KILTANTVVSAENASLQ-TMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENL 1899
            |::..:.||.....|.. :|...::.|:...|.:   |.....|:|..|.|....|.|.::
Mouse  1167 KMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTE---ELFKDDVEGMMSQGQRPTTPIPDI 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	164/533 (31%)
Chd5	XP_006538992.1	CHDNT	148..203	CDD:462357
		PHD1_CHD_II	347..389	CDD:277006
		PHD2_CHD_II	420..462	CDD:277007
		CD1_tandem_CHD3-4_like	467..546	CDD:349314
		CD2_tandem_CHD3-4_like	591..644	CDD:349309	6/52 (12%)
		PLN03142	700..>1218	CDD:215601	172/569 (30%)
		DUF1087	1300..1353	CDD:461922
		CHDII_SANT-like	1394..1534	CDD:461920
		LGT	<1535..1687	CDD:469786
		CHDCT2	1734..1879	CDD:462358