DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and mot1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_596080.2	Gene:	mot1 / 2539633	PomBaseID:	SPBC1826.01c	Length:	1953	Species:	Schizosaccharomyces pombe

Alignment Length:	2147	Identity:	754/2147 - (35%)
Similarity:	1100/2147 - (51%)	Gaps:	421/2147 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTV 65
            ||:|||||.:||::|||:..|:.||||||::||::|.||:.||.|:|.||.|.:|:||:|||:.:
pombe     1 MTTRLDRLVVLLDSGSTSVVRETAAKQIGDIQKVHPDELYNLLGRVVPYLKSKNWDTRVAAAKAI 65

  Fly    66 EAILKQVPPWQP---------EFQVLPK-----KERCATNTATAAAAAEEDSCQSSGSNSTTASE 116
            ..|::.||.|.|         |.:.||.     :|:....|...|.|:.:.....| ||.|:.||
pombe    66 GGIVENVPVWNPNRTSPVKKEETEDLPSFNGDTEEKPFIKTEEGAPASSQSQVVVS-SNLTSNSE 129

  Fly   117 --------------------------------------------RLLSFDEFDLQQILHKGARLI 137
                                                        .||||:.||:..:|..|.:|:
pombe   130 VSKLEEERLSTRSHSQEIKPIVDFGPDEETAKELNTELKGKFENSLLSFESFDIANVLKAGKKLL 194

  Fly   138 GSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDEDVALNR 202
            ||...::||   .||        :.::...:|.:.|..:|.|.     |..|.|.|      :|.
pombe   195 GSASRDYDV---NPA--------NYSTHYLQQLSNLKSRLDLA-----GEYLDDSI------MND 237

  Fly   203 SGSTYNVNAEKLPVEHLLNIKTAANG---------SGQAPLSCREMNRAKRKARQ--NTSGCSVT 256
            .|.....|::..|...:...||:.|.         |....||.|:.|..||||||  |:....|.
pombe   238 LGDNVGSNSKGSPTTSIPEHKTSINNNKPEDTPTPSENVHLSARQRNALKRKARQMKNSQKVRVI 302

  Fly   257 AVTPTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLKSTDRQEIFYSLNAAVPDATGTWVDA 321
            .|.||..       |...|..|::..|||......:.:   :||..:.:........|.....|:
pombe   303 DVAPTLV-------HQQNSTSSADKKTGADYNFTAQSR---SDRLVVEHKAPIVPSAAVAVTSDS 357

  Fly   322 VSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTREQMDEAHSRWLEDAA 386
            | ||.|.....|.||:|...||:||||...|||:|.....|.|:.|.::..:.::.:.::.:|..
pombe   358 V-WPFETLVELLLIDMFDPSWEIRHGACMGLREIIRYAGFGYGRVVGKSEAENEQLNKKYFDDLL 421

  Fly   387 LRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQLIQHKNE----- 446
            .|:.||..||||||:::||||||:||:.:||||..:..:....|..:..:|..|: .:||
pombe   422 CRIACVFALDRFGDYLADQVVAPIRESVSQVLGVALIYVPNDSVFSMYKVLHSLV-FQNELGLTN 485

  Fly   447 --WDVRHGGLLGLKYVFVVREELL---PIYLPQSISNILIGLLDAVDDVGAVAAATLIPVSSWL- 505
              |:..|||:||:||:..|:..|.   ..||...|:.::.||.:..|||.||:|.||:|::..|
pombe   486 TVWEAAHGGMLGIKYLVAVKYPLFFSHSDYLDSLINTVIHGLANHDDDVRAVSALTLLPIADKLV 550

  Fly   506 -PKLLNPAQVSSIVKMLWDLLLD-QDELTSACNSFMGLLAAILCLPNAARWVE----MEP---MA 561
             .||   :...:::|:|||.|.| :|:|:|:.:..|.||:::.........::    .:|   ..
pombe   551 QEKL---SSCKNLLKVLWDCLDDVKDDLSSSTSCVMDLLSSLCSFTEVMNLMQETANSDPEFSFE 612

  Fly   562 ILVPRLWPFLSHSTSSVRRSTLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWE 626
            .|||||:..:.::.:.||||.:..|....|..                           :...|
pombe   613 TLVPRLFHLMRYTLTGVRRSVVYALTKFISVQ---------------------------TSCSW- 649

  Fly   627 LLQQALRHIYQRILVEPQADIQ----ALARQVWSNLIQHA--DLGALLHAACPFVSSWICLSMQP 685
            :....||..:|.:|:|.|.||.    .||::|...|.:..  ....||::   .:...:.:|:.|
pombe   650 ITGLTLRLCFQNVLLEQQEDISKSSCELAQRVMDILYRDGPESFSKLLYS---HIEPMLKVSITP 711

  Fly   686 ------PRLAFDAGVLIRAGGDVSTPGSTSRKRTPRIGDELGGNILAQSNASLKLYL----GGSE 740
                  | ...|..::::..|....| ||||:|        ..||...||:..|...    .||.
pombe   712 IGSFRRP-YPLDTTLIVKPSGQPYAP-STSRER--------NNNISELSNSRTKHRAKDDPKGSF 766

  Fly   741 ATPLD----------VRDANFMRARISSSRALGALSHYLVQPAPGVVYTPQTESPTDCYTK---- 791
            ...:|          |.:...::||:.:|..||.:.....:....:.:.|..::   |.|.
pombe   767 CFSVDEPMLNGDVEFVGEERMLKARLRASSLLGRIIGRWKRDEILLFFKPFLQA---CLTSSFST 828

  Fly   792 -VLLGHLNAHSAVQRIVCGLIIAFWALEDEPV-------------------RPGPPNLQEKLH-- 834
             |:||            ..||.:|:.:||..:                   |....||..:||
pombe   829 PVVLG------------SRLIESFFEVEDNDLTIQKDELYHLLCDQFATVPRENYANLVSQLHVV 881

  Fly   835 --QCVSEYVYYDEVAISLTRLLQEAQDFIATLKQNKIP------------------INDF----- 874
              ||              ..||....| :..|.::|||                  |.|.
pombe   882 RAQC--------------NALLNTFLD-VGRLSRSKIPSLAVVVKGDPEAGPIAFGIADAEKLVG 931

  Fly   875 ----NNAKILTLDQIEAVATTLSENLRSYPLKPKVLD-----MLEERRRSLQASYQQTTSEQSAY 930
                |..|:|:..|....:..|:|      :|..::|     .:.:.|:.:|.|
pombe   932 PTYENLCKLLSPSQKAQSSKALNE------IKYLIIDEISIYKIAKERQDIQCS----------- 979

  Fly   931 HVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQ--CLQLQQLSAEFLVHLMDQVCDRNPSP 993
                 |::|.|:.....||.|||.::|.:|||||:||  |||:...||  ::.|: ..|.:....
pombe   980 -----ASIASAMVTYDKLPKKLNSIIKGIMESIKKEQFSCLQMHSASA--MMKLI-SACYKESRQ 1036

  Fly   994 --NSKILNNLCTLLRSDPEFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRS 1056
              :.||:.|||..:..|             ..:||:..:...|    |||:|   .::.|::...
pombe  1037 VISEKIVRNLCAYVCMD-------------TTETPIFHDSGKN----GILSL---HSIGTSDDND 1081

  Fly  1057 GAGGATTPTATTAPRGPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLC 1121
                              ...:|:::..::..:: :.|:..:..::.....:||:||...::::.
pombe  1082 ------------------EQVSGKLVDDSDDVSN-DRKSSLSSVSDKDAAVLQRMGAQLTLQQMA 1127

  Fly  1122 RIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVAL 1186
            :.||..:..:|.|....:|..::|:.:..:...:......:|  .:|:.:|.::.....:|...|
pombe  1128 QNFGSSLFSRVPVLSQCLFVPLQQYAESGFPSEVDQASCTVG--QDLLDAMSILRFLVAYLDSGL 1190

  Fly  1187 HPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDAC--QTMQFVVHDLLPLLGKIEQLIERQ 1249
            ..::.:.||.|...:.....|||:||::|.|.:.|.:|.  :.:..:|.|::||||.....|.||
pombe  1191 QSEIVSTLPHLLATLQSNYSAVRNMASKCFAAITESNAAGSKALHLLVEDVVPLLGDASSTIHRQ 1255

  Fly  1250 GAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKS 1314
            ||||.|..||.||.::::|||:.|::||||.|||.|:.||:|:|..||.||:|:||:...    .
pombe  1256 GAIECIYHVVQRLGVRILPYILYLIIPLLGRMSDADQDVRVLATTSFATLVKLVPLEAGL----P 1316

  Fly  1315 DP-------LQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGI 1372
            ||       |.:|: ::|:||:.:.||..:..:.:|||||.:||.|||.|:|||.|||||.||||
pombe  1317 DPPDLPQYLLDSRE-KERKFLEQMLNPSKVEAFSIPVPISADLRKYQQEGVNWLAFLNKYELHGI 1380

  Fly  1373 LCDDMGLGKTLQTICILAGDHMHRQ-------TANLANLPSLVICPPTLTGHWVYEVEKFLDQGS 1430
            ||||||||||||||||:|.||.:||       :...|::|||::||.||.|||..|:..:   ..
pombe  1381 LCDDMGLGKTLQTICIVASDHYNRQKLFEESGSPKFAHVPSLIVCPSTLAGHWQQELSTY---AP 1442

  Fly  1431 VLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKS 1495
            .|:...|.|.|..|.|:||.: .|.::||.|||..|.|:|....|.:|||||||||:|||.:.|.
pombe  1443 FLKVSAYVGPPAERAKIRSKM-KKSDVVVTSYDICRNDVDELVKIDWNYCVLDEGHVIKNARAKL 1506

  Fly  1496 SKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKE 1560
            :||:|.|::.|||||||||||||||||||||||||||||||||.|.:||.|||.:|||||||:||
pombe  1507 TKAVKSLRSYHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKTFQERFVRPIAASRDAKSSSKE 1571

  Fly  1561 QEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDF-----SNKHLK 1620
            :|.|.||:||:|:|||||:|||:|||||.||||||.||..|::|.||.:|..||     .|:.|:
pombe  1572 RERGTLALEAIHKQVLPFMLRRLKEDVLADLPPKIIQDYYCDMSDLQRKLLNDFVSQLNINEELE 1636

  Fly  1621 DCLDKLGDSSSASMVT-ENLSAKTHIFQALRYLQNVCNHPKLVLRQSE-ELTKVTSQLALSNSSL 1683
            |      |.:..:..| :..|.|.||||||:|::.:||||.|:|.:.. :...:..|||..||.|
pombe  1637 D------DETEKTQGTRKKKSQKAHIFQALQYMRKLCNHPALILTEKHPKRNAIVKQLAKENSGL 1695

  Fly  1684 DDIEHSAKLPALKQLLLDCGIG-----------VQTESVSQHRALIFCQLKAMLDIVEQDLLRRH 1737
            .|::|:.||.||.|||.|||:|           ..|.:||:||.|||||||.|||:||:|||:..
pombe  1696 HDLKHAPKLTALGQLLRDCGLGNSSVNSNGIDSALTNAVSEHRVLIFCQLKDMLDMVEKDLLQAT 1760

  Fly  1738 LPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKD 1802
            :|.|||:||||||..::||:.|..||:|||||||||||.||||||||||||||||||||||||:|
pombe  1761 MPDVTYMRLDGSVEPTKRQEAVTKFNNDPSIDVLLLTTHVGGLGLNLTGADTVIFVEHDWNPMRD 1825

  Fly  1803 LQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLF 1867
            ||||||||||||||||||||||||..|||||||||:||:..|:|||:.:||.|.::||.||.|||
pombe  1826 LQAMDRAHRIGQKKVVNVYRLITRGCLEEKIMGLQRFKMNVASTVVNQQNAGLSSIGTDQILDLF 1890

  Fly  1868 NG-----------GKDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDLGNFVQAL 1921
            |.           .|::..::....:.||:      ...:|.|||:|.|.|| :|::|..|:..|
pombe  1891 NTTADEQQTVQNIDKEESEDAAGRGLSGTS------KKALEGLPEMWDESQY-DEFNLDGFISTL 1948

  Fly  1922 KK 1923
            .|
pombe  1949 PK 1950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787	15/24 (63%)
		HEAT repeat	42..70	CDD:293787	14/27 (52%)
		HEAT repeat	395..420	CDD:293787	17/24 (71%)
		HEAT repeat	433..465	CDD:293787	13/38 (34%)
		HEAT repeat	475..504	CDD:293787	12/28 (43%)
		HEAT repeat	516..540	CDD:293787	9/24 (38%)
		HEAT repeat	560..589	CDD:293787	10/28 (36%)
		DUF3535	654..1138	CDD:288874	114/569 (20%)
		HEAT repeat	1234..1261	CDD:293787	15/26 (58%)
		HEAT repeat	1269..1298	CDD:293787	16/28 (57%)
		SNF2_N	1353..1662	CDD:278600	185/321 (58%)
		DEXDc	1370..1514	CDD:238005	78/150 (52%)
		Helicase_C	1689..1813	CDD:278689	91/134 (68%)
mot1	NP_596080.2	HEAT repeat	5..30	CDD:293787	15/24 (63%)
		HEAT repeat	42..70	CDD:293787	14/27 (52%)
		DUF3535	689..1144	CDD:288874	112/561 (20%)
		SNF2_N	1361..1673	CDD:278600	185/321 (58%)
		DEXDc	1378..1525	CDD:238005	78/150 (52%)
		HELICc	1721..1844	CDD:238034	88/122 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	333	1.000	Domainoid score	I203
eggNOG	1	0.900	-	-		E1_KOG0392
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31978
Inparanoid	1	1.050	1059	1.000	Inparanoid score	I29
OMA	1	1.010	-	-		QHG55547
OrthoFinder	1	1.000	-	-		FOG0004898
OrthoInspector	1	1.000	-	-		oto101655
orthoMCL	1	0.900	-	-		OOG6_101665
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R735
SonicParanoid	1	1.000	-	-		X3453
TreeFam	1	0.960	-	-
	14	13.860