Protein Alignment Hel89B and ssl-1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001255179.1
• Gene: ssl-1 / 190954
• WormBaseID: WBGene00007027
• Length: 2395
• Species: Caenorhabditis elegans
• Alignment Length: 1545
• Identity: 329/1545 - (21%)
• Similarity: 523/1545 - (33%)
• Gaps: 605/1545 - (39%)

  Fly   741 ATPLDVRDANFMRARISSSRAL-----GALSHYLVQPAPGVVYTPQ----TESPTDCYTKVLLGH 796
            |||  ||.::...:|.:|||::     ...|.....|:|..:.|.:    .|......|...|..
 Worm     3 ATP--VRASSTRISRRTSSRSVADDQPSTSSAVAPPPSPIAIETDEDAVVEEEKKKKKTSDDLEI 65

  Fly   797 LNAHSAVQR---IVCGLIIAFWALEDEPVRPGPPNLQEKLHQCVSEYVYYDEVAISLTRLLQEAQ 858
            :...:.|.|   .:|.:::.    |:..:|                    |::.:|...:.||..
 Worm    66 ITPRTPVDRRIPYICSILLT----ENRSIR--------------------DKLVLSSGPVRQEDH 106

  Fly   859 DFIATLKQNKIPINDFNNAKILTLDQIEAVATTLSENLRSYPLKPKVLDMLEERRRSLQASYQQT 923
            :......|...|:          :|||:.|...:        |...|.|:|::.|.::.|...:.
 Worm   107 EEQIARAQRIQPV----------VDQIQRVEQII--------LNGSVEDILKDPRFAVMADLTKE 153

  Fly   924 TSEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQCLQLQQLS------------- 975
            .....|                  .|..:...::|:...|:..:.....|.|
 Worm   154 PPPTPA------------------PPPPIQKTMQPIEVKIEDSEGSNTAQPSVLPSCGGGETNVE 200

  Fly   976 --AEFLVHLMDQVCDRNPS---PNSKILNNLCTLLRSDPEFTPKLVMP----------LETLKQT 1025
              |:...|::.::.:...:   .||::               ||.|.|          ||.:|..
 Worm   201 RAAKREAHVLARIAELRKNGLWSNSRL---------------PKCVEPERNKTHWDYLLEEVKWM 250

  Fly  1026 PVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEILSATNATAH 1090
            .|...                   |.|||:.                    ...::::...|..|
 Worm   251 AVDFR-------------------TETNTKR--------------------KIAKVIAHAIAKQH 276

  Fly  1091 --IELKAQQAKEAEAKQCRIQRLGAA-------CAIEKLCRIFGEQIIE---KVAVFQHLMF--G 1141
              .:::.::|.|.|.|:.|....|.|       .:.:|:..|..::::|   :.|..:||||  |
 Worm   277 RDKQIEIERAAEREIKEKRKMCAGIAKMVRDFWSSTDKVVDIRAKEVLESRLRKARNKHLMFVIG 341

  Fly  1142 KVEQ---FVKEAYDWRLGSLLPDLGVCNELVSSMQLIETA-----------APHLHVALHPQMFA 1192
            :|::   .|:|.                 ||||.:....|           ||........:.
 Worm   342 QVDEMSNIVQEG-----------------LVSSSKSPSIASDRDDKDEEFKAPGSDSESDDEQ-- 387

  Fly  1193 LLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHD---------LLPLLGKIEQLIER 1248
                   .:.:..|:.:....|     .|:||.|....|..|         .|...|..::.:|.
 Worm   388 -------TIANAEKSQKKEDVR-----QEVDALQNEATVDMDDFLYTLPPEYLKAYGLTQEDLEE 440

  Fly  1249 QGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRL-LSTHCFANLVQLMPLDGKTEQL 1312
            ... |.:|...:|.:                |..|.:|.:.: .|....|........|...|||
 Worm   441 MKR-EKLEEQKARKE----------------ACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEQL 488

  Fly  1313 KSDPLQARKTRD----REFLDYL-----------------------FNPK----SIPNYKVPVPI 1346
            : ||.......|    .|.:||:                       |.||    .....|.|||.
 Worm   489 Q-DPTAEDGNGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVKTPVPF 552

  Fly  1347 SV--ELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVI 1409
            .:  :||.||..|::|:..|.:.||:|||.|:||||||:|||.:||    |...:.....|.|::
 Worm   553 LIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLA----HMACSESIWGPHLIV 613

  Fly  1410 CPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGR-EKLRSDIGTKC-NLVVASYDTVRKDIDFF 1472
            .|.::..:|..|.:|:.   ..|:.|.|:|....| ||.:..:...| ::.:.||.||.:||..|
 Worm   614 VPTSVILNWEMEFKKWC---PALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAF 675

  Fly  1473 SGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTE 1537
            ....:.|.:|||...|||.|::..:|:..::|..||:|:|||:||:::|||||..||||....:.
 Worm   676 KQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSH 740

  Fly  1538 KQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCE 1602
            ..|...||.|:....:.     ..|.....:..||:.:.||:|||:|::|.|.||.|....:.|.
 Worm   741 DDFKDWFSNPLTGMMEG-----NMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCS 800

  Fly  1603 LSPLQLRLYEDFSNK--------------------HLKDC-----------------LDKL---- 1626
            ||..|..||:||.::                    .|:.|                 ::||
 Worm   801 LSKRQRYLYDDFMSRRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQLDV 865

  Fly  1627 -----------GDSSSASMVTE--NLS-------------------------------------- 1640
                       ..|||||.:.|  |||
 Worm   866 PARLFEISQQDPSSSSASQIPEIFNLSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVGGFRFN 930

  Fly  1641 --------------------------------------------------------AKT------ 1643
                                                                    :||
 Worm   931 RTAFVAKNPHTEESEDEGVMRSRVLPKPINGTAQPLQNGNSIPQNAPNRPQTSCIRSKTVVNTVP 995

  Fly  1644 ----------------------------------------------------HIFQ--------- 1647
                                                                |:.:
 Worm   996 LTISTDRSGFHFNMANVGRGVVRLDDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEESRKNQ 1060

  Fly  1648 ---------------------ALRYLQNVCNHPKLVLRQSE----------EL------------ 1669
                                 ||...:.:...|:|.:.:.|          ||
 Worm  1061 LEIVRRRFEMIRAPIIPLEMVALVREEIIAEFPRLAVEEDEVVQERLLEYCELLVQRFGMYVEPV 1125

  Fly  1670 ------------------------TKVTSQLALSNSSLD-----DIEHSAKLPALKQLLLDCGIG 1705
                                    .::.|:..|.|:|.:     .|..:.:.|.|:.:..||| .
 Worm  1126 LTDAWQCRPSSSGLPSYIRNNLSNIELNSRSLLLNTSTNFDTRMSISRALQFPELRLIEYDCG-K 1189

  Fly  1706 VQTESV-------SQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFN 1763
            :||.:|       .:||.|||.|:..|||:: |..|..|  ...|.||||:....|||.::..||
 Worm  1190 LQTLAVLLRQLYLYKHRCLIFTQMSKMLDVL-QTFLSHH--GYQYFRLDGTTGVEQRQAMMERFN 1251

  Fly  1764 SDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNS 1828
            :||.:...:|:|..||:|:||||||||||.:.||||..|.||.||.|||||.:.|::||||:..:
 Worm  1252 ADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERT 1316

  Fly  1829 LEEKIM--GLQKFKILTANTVVSAENASLQTMGTSQIF-------DLFNG 1869
            :||.|:  ..||.::        .|.|..:...|.:.|       |||:|
 Worm  1317 IEENILRKATQKRRL--------GELAIDEAGFTPEFFKQSDSIRDLFDG 1358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	72/448 (16%)
		HepA	<1342..1849	CDD:440319	201/806 (25%)
ssl-1	NP_001255179.1	HSA	231..295	CDD:462194	16/102 (16%)
		PLN03142	372..>851	CDD:215601	139/522 (27%)
		DEXQc_SRCAP	558..780	CDD:350761	83/233 (36%)
		SF2_C_SNF	1183..1312	CDD:350180	62/132 (47%)
		Med15	1978..>2359	CDD:312941