Protein Alignment Hel89B and pqn-15

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001367558.1
• Gene: pqn-15 / 180705
• WormBaseID: WBGene00004106
• Length: 2171
• Species: Caenorhabditis elegans
• Alignment Length: 1298
• Identity: 301/1298 - (23%)
• Similarity: 508/1298 - (39%)
• Gaps: 383/1298 - (29%)

  Fly   685 PPRLAFDAGVLIRAGGDVS----------TPGSTSRKRTPRI-GDELGGNILAQSNASLKLYLGG 738
            ||.   :||.:|:.|.:::          |||....|...:. ..:..|.:.|:|:..|......
 Worm   723 PPN---NAGPMIQQGKNIAGGYPPNQNKVTPGKNVPKNQQQSRPQQANGKVQAKSSPDLSQPSTS 784

  Fly   739 SEATPLDVRDANFMR----ARISSSRALGALSHYLVQPAPGVVYTPQTESPTDCYTKVLLGHLN- 798
            .:..|.:..|...:|    :.:..||.:                ||:       |.:.:...||
 Worm   785 KQRPPANKADMTVIRDAIVSHVKGSRKM----------------TPE-------YIEYVCEELNR 826

  Fly   799 --------------AHSAVQRIVCGLIIAFWALEDE-------PVRPGP---PNLQEKLHQCVSE 839
                          .:.:|::::.       .:::|       |..|.|   |..:|.|.....:
 Worm   827 LMRELEKADMKTDRRYISVRKLLA-------LIQEEKLTIIIPPRIPMPARYPPTEESLGDEPVD 884

  Fly   840 YVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQI---EAV----------ATT 891
            ....|..|        ...|::..| .|..|:|.:::..:...|.|   ||:          ...
 Worm   885 ETVEDRAA--------RYDDYMQVL-ANAYPLNTWDSNFMKIDDDIIRKEALHYRDQDMKNREMY 940

  Fly   892 LSENLRSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPVV 956
            |.|||.::|         |||:...:..|...:.      :..|..|...:.|...|....:.::
 Worm   941 LKENLHTFP---------EERQTKAKIEYLGLSL------LDFQTELRKKVLATTVLVPPNDFLI 990

  Fly   957 KPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPLET 1021
            .|.  ||:|.:...||:|.......::::   |....|...|.:|....|...||..:     ..
 Worm   991 NPW--SIRRTKYEYLQELKRHPDRAILEK---RRKVTNFHFLQSLTKHAREFKEFHKR-----NM 1045

  Fly  1022 LKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEILSATN 1086
            |..|.|..              ::||.:|..|.|
 Worm  1046 LNHTKVRK--------------SMQQYITNENKR------------------------------- 1065

  Fly  1087 ATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAY 1151
             .|..|:|.::.        |||:|                |.|....::.::        .|..
 Worm  1066 -IAREEMKNEKN--------RIQKL----------------IQEDEEGYRAML--------DEKK 1097

  Fly  1152 DWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCI 1216
            |.||..||..   .::.:.|:                             |..||..::..|..:
 Worm  1098 DQRLVYLLEQ---TDDYIKSL-----------------------------CDLLKQQQNATAGSL 1130

  Fly  1217 AVLAEIDACQTMQFV--VHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLG 1279
            |         |..::  .:|.:....|::.::::
 Worm  1131 A---------TKSYIRKEYDGVAEEDKVKSILDK------------------------------- 1155

  Fly  1280 AMSDPDESVRLLSTHCFANLVQLMPLD------GKTEQLKSDPLQARKTRDREFLDYLFNPKSIP 1338
            |.:|.||         :.|..::...|      |..|::|          ::.|:....||
 Worm  1156 ARNDDDE---------YENKTKMNIEDYYTTAHGVREEIK----------EQHFMMGGGNP---- 1197

  Fly  1339 NYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLAN 1403
                    |::|:.||..|:.|:..|...||:|||.|:||||||:|||..:......::|:.
 Worm  1198 --------SLKLKPYQIKGLEWMVSLFNNNLNGILADEMGLGKTIQTIAFITYLMEIKKTSG--- 1251

  Fly  1404 LPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDI--GTKCNLVVASYDTVR 1466
             |.|||.|.:...:|..|.:|:   .:.:..:.|.| |....|:...|  ..|.|:::.:::.|.
 Worm  1252 -PFLVIVPLSTVPNWQNEFDKW---AANVHLIAYKG-PKETRKVFEPIIKSGKFNVLLTTFEYVI 1311

  Fly  1467 KDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIK-RLKANHRLILSGTPIQNNVLELWSLFDFLM 1530
            ::......:.:.|.::||||.:||...|.::.:. |.:...||:::|||:||.:.|||:|.:||:
 Worm  1312 REKALLGKLRWKYMIIDEGHRLKNQHCKLTEMLNTRFQCQRRLLITGTPLQNKLPELWALLNFLL 1376

  Fly  1531 PGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKI 1595
            |....:...|.|.|:.|..::  .:.....||..:|.:..||:.:.||||||:|::|..:||.|:
 Worm  1377 PSIFSSCSTFEQWFNAPFATT--GEKVELTQEETMLIIRRLHKVLRPFLLRRLKKEVESELPDKM 1439

  Fly  1596 TQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPK 1660
            ...:.|::|.||..||     ||::..|...|.:::.|....|         .:.:|:.:||||.
 Worm  1440 EFVVRCDMSALQKVLY-----KHMQKGLLLDGKTNTGSKSLRN---------TMIHLRKLCNHPF 1490

  Fly  1661 LVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAM 1725
            |.....|.......  |...|::|....|.||..|.::|       .....:.||.|:|.|:.:|
 Worm  1491 LFENVEESCRNFWD--ARFISAVDLYRVSGKLELLSRIL-------PKLQATGHRVLMFFQMTSM 1546

  Fly  1726 LDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGLNLTGAD 1788
            :.|||..|..   .::.|||||||....:|..:::.||: |:.:  :.:|:|..|||||||..||
 Worm  1547 MTIVEDFLAG---GTIQYLRLDGSTKPDERGALLDKFNA-PNSEYFLFMLSTRAGGLGLNLQTAD 1607

  Fly  1789 TVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENA 1853
            |||..:.||||.:|:||.|||||||||..|.|:||||.||:||||:...::|:.....|:.|..
 Worm  1608 TVIIFDSDWNPHQDMQAQDRAHRIGQKAEVRVFRLITANSVEEKILAAARYKLNVDEKVIQAGK- 1671

  Fly  1854 SLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDLGN 1916
                      ||    .:..|||               ...|:||:  :.:|::.||:.::.|
 Worm  1672 ----------FD----NRSTGAE---------------RREILENI--IKTENESEEDEEVPN 1703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	87/505 (17%)
		HepA	<1342..1849	CDD:440319	174/511 (34%)
pqn-15	NP_001367558.1	Med15	<1..>288	CDD:312941
		Med15	<372..>592	CDD:312941
		HSA	1011..1083	CDD:214727	22/149 (15%)
		PLN03142	1062..>1726	CDD:215601	225/878 (26%)
		SnAC	1727..1799	CDD:464219