Protein Alignment Hel89B and F54E12.2

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_502137.1
• Gene: F54E12.2 / 178054
• WormBaseID: WBGene00010061
• Length: 1091
• Species: Caenorhabditis elegans
• Alignment Length: 1162
• Identity: 265/1162 - (22%)
• Similarity: 439/1162 - (37%)
• Gaps: 381/1162 - (32%)

  Fly   890 TTLSENL-RSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPD--- 950
            |.:|:.| .|..|:.|.    :.|.|.|:.|.:| .:|.|:...:|.....|:...:...|:
 Worm   122 TPISKKLAESTDLRSKA----QLRERLLRKSLKQ-NAEDSSPTRAASGGGWGSSADVKKSPEVST 181

  Fly   951 -KLNPVVKPLMESIKREQ------CLQLQQLSAEFLVHLM---DQVCDRN-PSPNSKILNNLCTL 1004
             .....:.|:.:|.:|..      .|.:|:::....::.:   :::.|.: |:|.:       |.
 Worm   182 GLFETALSPIAKSDRRSSEYNSSTFLNVQKVATSTAINDIGGREEIVDESFPAPRT-------TA 239

  Fly  1005 LRSDP---EFTPKLVMPLETLKQTPV----SSEVINNCVYYGILTLALQQTVTTTNTRSGAGGAT 1062
            .:.|.   |.||:.|:..|..|....    .|::|:                            .
 Worm   240 KQDDSDIIEVTPEKVVSNEKRKSGIAINLDDSDIID----------------------------V 276

  Fly  1063 TPTATTA--PRGPGRP--PTGEILSATNATAHIELKAQQAKEAEAKQCRIQRL---------GAA 1114
            ||..||:  |..|.||  ||..|.|        |......||..||:.::..|         |
 Worm   277 TPVKTTSSRPPEPQRPRLPTSPINS--------EYAKLSYKELLAKKNKVMGLISLSLDLPDG-- 331

  Fly  1115 CAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQ-----L 1174
                      |.::|::   ||.| ..:||:             ..::|:..|:|...:     :
 Worm   332 ----------GRRVIKQ---FQEL-DDEVER-------------RKEMGLAEEIVDDDEDDEIFV 369

  Fly  1175 IETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLP-- 1237
            ||...|.     |.|:....||...:..:.|...||:          :|..:..|...:.:|.
 Worm   370 IEDDEPS-----HRQVAPKFPSGSVMTQNGLLPKRHI----------VDPLKAPQPDFNAMLEKD 419

  Fly  1238 ----LLGKIEQLIERQGAIEAI-ERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFA 1297
                :.||:..  |:...|:.: :|||.  |:....:.:            |||:
 Worm   420 NKKMMSGKMTD--EKYKRIQLVSDRVVR--QLAEATHTI------------PDET---------- 458

  Fly  1298 NLVQLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWL- 1361
                                        |..|            .|....:||..:|:||:.|:
 Worm   459 ----------------------------ELTD------------TPKGFKLELMPHQKAGLTWMR 483

  Fly  1362 WFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLAN---------------------LP 1405
            |...:....|||.|||||||||..|.::|    |::.|..|.                     :|
 Worm   484 WRETQPQPGGILADDMGLGKTLSMISLIA----HQKAARRARREDGNDDKDKEKRKVVKEQGLIP 544

  Fly  1406 S---LVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIG----TKCNLVVASYD 1463
            |   |::.|.:|...|..|:::.||. |||....::|     .|.:.||.    .:.::|:.:::
 Worm   545 SNGTLIVAPASLIHQWDAEIDRRLDD-SVLSTYMFHG-----TKKQRDIDARRLARYDVVITTFN 603

  Fly  1464 ---------------------------------TVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKS 1495
                                             .|.||....:.|.::..:|||.|.|||.::.:
 Worm   604 LIANELIEKIRTKSKADDSSDGESDSNHTGIRRAVGKDDSVLAQICWSRVILDEAHTIKNRQSLA 668

  Fly  1496 SKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRF--SRPILSSRDAKSSA 1558
            |||:.||.|..|..||||||.||:.:|:||..||.......:|.:.:..  .:||::.|
 Worm   669 SKAVCRLSAFSRWCLSGTPIHNNLWDLYSLVRFLRIRPFSDDKYWKESIMPMKPIMADR------ 727

  Fly  1559 KEQEAGVLAMEALHRQVLPFLLRRVKEDV-------LKDLPPKITQDLLCELSPLQLRLYE---D 1613
                     :..|.:.:   ||||.|:..       |..||||..:....||...:.:.||   :
 Worm   728 ---------VNLLTKNL---LLRRTKDQTCAVTNQKLVQLPPKNVEVHELELDGDEAQAYEIMME 780

  Fly  1614 FSNKHLKDCLDKLGDSSSASMVT--------------------------ENLSAKTHIFQALRYL 1652
            .:.|.:|..|....|..:...:.                          .|....:.:...|..|
 Worm   781 AAKKFVKKLLQDSNDMKNHGFIPRRNRRAGKEGEVQNPFNFGPRDLAAGSNFEKMSCVLMLLLRL 845

  Fly  1653 QNVCNHPKLVLRQSEELTKVTSQL-ALSNSSLDDIEHSAKLPALKQLL-----LDCGIGVQTESV 1711
            :..|.|        ..:||....: |.|....|:.| .|.:..|.:||     :..|.| ..|..
 Worm   846 RQACVH--------FNITKTGVDMDAFSLIGGDNAE-EANVDDLNELLEKTMNMTLGNG-DNEER 900

  Fly  1712 SQHRAL--IF------CQLKAMLDIVEQ------------------DLLRRHLPS--VTYLRLDG 1748
            .:.||.  ||      |::|..|:|||.                  :|:..|:.|  ..|..:.|
 Worm   901 DKPRATTRIFDPDYLSCKIKNTLEIVENIMEKKEKVVIVSQWTSVLNLIEIHIKSSGFKYTSITG 965

  Fly  1749 SVPASQRQDIVNNFNSDP-SIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRI 1812
            .|....||:.|::||.:. ...|:||:...||:||||||.:.::.|:..|||..:.||.||.:|:
 Worm   966 QVLVKDRQERVDSFNREKGGARVMLLSLAAGGVGLNLTGGNHLVMVDLHWNPALEQQAFDRIYRM 1030

  Fly  1813 GQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENAS--LQTMGTSQIFDLF 1867
            ||||.|.::||:|:.::|::::.|||.|:..|::|:.. ||:  :..:.|:.|..||
 Worm  1031 GQKKDVFIHRLVTKGTIEQRVVMLQKDKVALASSVLDG-NATRKMNKLTTADIKMLF 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	57/282 (20%)
		HepA	<1342..1849	CDD:440319	170/641 (27%)
F54E12.2	NP_502137.1	HepA	<458..1067	CDD:440319	172/696 (25%)