Protein Alignment Hel89B and swsn-4

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_502082.1
• Gene: swsn-4 / 178015
• WormBaseID: WBGene00004204
• Length: 1474
• Species: Caenorhabditis elegans
• Alignment Length: 1258
• Identity: 311/1258 - (24%)
• Similarity: 478/1258 - (37%)
• Gaps: 390/1258 - (31%)

  Fly   813 AFWALEDEPVRPGPPNLQEKLHQCVSEYVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNA 877
            ||.....:|.:|.    .|.:.|...:.....|:.||      :.::.|.::::..:. ||..:|
 Worm     6 AFEQFTAQPPQPA----GEVVAQQAGDGAQGQELTIS------KLENAITSMEEQGLQ-NDHRHA 59

  Fly   878 KILTLDQ------IEAVATTLSENLRSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQA 936
            |.:.|.|      .:||..  .||..:..:.|..|:.|   |..:.|......:||...::.|.|
 Worm    60 KAVLLKQKLQSGLPDAVPG--QENGGNQQITPAQLNQL---RAQVSAYRLLARNEQVPANLIADA 119

  Fly   937 ALAGAICALHCLPDKLNPVVKPLM--------ESIKREQC-LQLQQLSAEFLVHLMDQV-CDRNP 991
            .:             |.|.|..|:        |:...|:. ..|.::   |.:|   |: |:| |
 Worm   120 VM-------------LRPKVTTLLPEPYEYPGEAENGEKLPYDLMKI---FNLH---QIRCNR-P 164

  Fly   992 SPNS--------------------------KILNNLCTLLRSDPEFTP-----KLVMPLETLK-- 1023
            :..|                          |:||||       |...|     |..:.|..|:
 Worm   165 TTISVPSGIDPVGMLKQRENMIQNRIGLRMKLLNNL-------PADIPDHMKLKAEIELRALRLV 222

  Fly  1024 --QTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEILSATN 1086
              ||.|.|||           :|..:..||..|      |..|.|.       |....:.|....
 Worm   223 NLQTQVRSEV-----------MACLKRDTTLET------ALNPYAY-------RRTKRQSLREAR 263

  Fly  1087 ATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVF---------------- 1135
            .|..:|.:.:..:|.:.:|.....:.|.....|..:.:....:.|:|..
 Worm   264 VTEKLEKQQKMEQERKRRQKHTDLMQAIIQHGKEFKEYHRNNLLKMAKSRKAVMTYHQNNERERK 328

  Fly  1136 ------QHLMFGKVEQFVKEAY--------DWRLGSLLPDLGVCNELVSSM-------------- 1172
                  :.|...|:.|..:|.|        |.||..||..   .:|.|.|:
 Worm   329 KDEIRNEKLRMQKLMQEDEEGYRALLDEKKDQRLVYLLQQ---TDEYVDSLCSLVRQHQNTEKKK 390

  Fly  1173 -----------QLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQ 1226
                       |:.|.|..|                          ||..:
 Worm   391 KKEDKKIEKGNQMDEEARVH--------------------------VRERS-------------- 415

  Fly  1227 TMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLL 1291
            |.:.:..|..|...:||..:|.....|.:.|                     ..:||.:|...
 Worm   416 TGKALTGDQAPKTEEIEFWLETHPEYEIVPR---------------------DQLSDDEEEEE-- 457

  Fly  1292 STHCFANLVQLMPLD----------GKTEQLKSDPL--QARKTRD-------REFLDYLFNPKSI 1337
                     :..|::          |..|:.|:..:  :||...|       ::..||......|
 Worm   458 ---------EEAPVEPEEEKDDQYAGMDEETKAKMILEKARNEEDEYDQKTKKQMADYYATAHKI 513

  Fly  1338 ---------------PNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTIC 1387
                           ||        :.|:.||..|:.|:..|...||:|||.|:||||||:|||.
 Worm   514 KEKVVKQHTTMGGGDPN--------LLLKPYQIKGLEWMVSLYNNNLNGILADEMGLGKTIQTIS 570

  Fly  1388 ILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIG 1452
            ::.    :.......|.|.|||.|.:...:|..|..|:...   :..:.|.|....|.::...|.
 Worm   571 LVT----YLMEVKQNNGPYLVIVPLSTLSNWQNEFAKWAPS---VTTIIYKGTKDARRRVEGQIR 628

  Fly  1453 TKC-NLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKR-LKANHRLILSGTPI 1515
            ... |:::.:|:.|.|:......|.:.|.::||||.:||...|.:..:.. ..|.|||:|:|||:
 Worm   629 KGAFNVLMTTYEYVIKEKALLGKIRWKYMIIDEGHRLKNHNCKLTLMLNGFFHAQHRLLLTGTPL 693

  Fly  1516 QNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLL 1580
            ||.:.|||:|.:||:|....:...|.|.|:.|..::  .:.....||..:|.:..||:.:.||||
 Worm   694 QNKLPELWALLNFLLPSIFSSCGTFEQWFNAPFATT--GEKVELNQEETMLIIRRLHKVLRPFLL 756

  Fly  1581 RRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHI 1645
            ||:|::|...||.|....:.|:.|.||..:|     :|::..|  |.|:..:|.....::...|
 Worm   757 RRLKKEVESQLPDKTEYVIKCDQSALQKVIY-----RHMQKGL--LLDAKMSSGARSLMNTVVH- 813

  Fly  1646 FQALRYLQNVCNHP--------------KLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPALK 1696
                  |:.:||||              |:......:|.:|..:|.|    ||.|     ||.||
 Worm   814 ------LRKLCNHPFLFPNIEDSCRAYWKVNEVNGTDLMRVAGKLEL----LDRI-----LPKLK 863

  Fly  1697 QLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDL-LRRHLPSVTYLRLDGSVPASQRQDIVN 1760
                          .:.||.|:|.|:.:|::|.|..| .||:    ||||||||....:|.|::.
 Worm   864 --------------ATGHRILMFFQMTSMMNIFEDFLNFRRY----TYLRLDGSTKPDERGDLLT 910

  Fly  1761 NFNSDPSIDVLL--LTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRL 1823
            .||: |:.|:.|  |:|..|||||||..|||||..:.||||.:|:||.||||||||||.|.|.||
 Worm   911 QFNA-PNSDLFLFMLSTRAGGLGLNLQTADTVIIFDSDWNPHQDMQAQDRAHRIGQKKEVRVLRL 974

  Fly  1824 ITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASG 1888
            ||.||:||||:...::|:.....|:.|                   ||.....:|:...|
 Worm   975 ITANSVEEKILAAARYKLNVDEKVIQA-------------------GKFDQRSTGAERKQ----- 1015

  Fly  1889 GMSMNTIIENLPELWSEHQYEEE 1911
                  ::|.:.:...|.:.|||
 Worm  1016 ------MLEQIIQADGEEEEEEE 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	76/397 (19%)
		HepA	<1342..1849	CDD:440319	183/525 (35%)
swsn-4	NP_502082.1	QLQ	88..116	CDD:462622	7/30 (23%)
		HSA	272..344	CDD:214727	8/71 (11%)
		BRK	403..446	CDD:462196	12/82 (15%)
		PLN03142	472..1288	CDD:215601	204/650 (31%)