Protein Alignment Hel89B and smrd-1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_499301.2
• Gene: smrd-1 / 176462
• WormBaseID: WBGene00010845
• Length: 989
• Species: Caenorhabditis elegans
• Alignment Length: 747
• Identity: 205/747 - (27%)
• Similarity: 336/747 - (44%)
• Gaps: 140/747 - (18%)

  Fly  1241 KIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVP--LLGAMSDPDESVRLLSTHCFANLVQLM 1303
            |.|.|:::           :|:..|:..: ||...|  :.|||....:.| ...|:.....::.:
 Worm   300 KKEDLLQQ-----------ARINDKIADF-VLANRPFEIYGAMVAKMKGV-TRGTNAIEAYMEFL 351

  Fly  1304 PLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYN 1368
            ...|...::..|......|..::|......|..:|..|.    ...|..||..|:.||..:...:
 Worm   352 EKRGILSRILDDCKDHAHTVTKDFERCTEGPLQLPLLKE----GCTLHDYQLIGVKWLIMMYNKD 412

  Fly  1369 LHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLR 1433
            |:.||.|:||||||:|.:..|:......:|.     |.|::.|.:...:|:.|..|:...   ::
 Worm   413 LNAILGDEMGLGKTIQIVAFLSYLKQIGKTG-----PHLIVVPSSTIENWIGEFHKWCPS---IQ 469

  Fly  1434 PLHYYGFPVGREKLRSDIGTK---CNLVVASYDTVRKDID---FFSGIHFNYCVLDEGHIIKNGK 1492
            .|.|||....|:.||..:..:   .::::.:|:.|....|   ||.....||.:.||||::||..
 Worm   470 LLTYYGSQDERKHLRHRVKKQKDHIDVILTTYNMVTSKSDDKKFFKNFSLNYVIYDEGHMLKNCD 534

  Fly  1493 TKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQF----------VQRFSR- 1546
            ::..:.:.::|...:::|:|||:|||::||.||..|::      .|.|          :|.|.:
 Worm   535 SERYRGLMKVKGKKKILLTGTPLQNNLIELISLMYFVL------SKVFNKYCEDITHLLQHFKQL 593

  Fly  1547 -PILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRL 1610
             |.|   |.|:.|..|:..:...:|:   :.|::|||:|..||..||.|..|.:..|:...|.:|
 Worm   594 GPAL---DTKNKALYQQDRIEEAKAI---LQPYILRRLKNQVLGSLPSKSEQIIEVEMKKPQKQL 652

  Fly  1611 YEDFSNKHLKDCL---DKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSE----E 1668
            |:     ::.:.|   ::.|||                :.:|..|:...|||  :||:||    :
 Worm   653 YD-----NIVEALQQSEESGDS----------------YGSLMRLRQAANHP--LLRRSEYTDQK 694

  Fly  1669 LTKVTSQLALSNSS---------------LDDIE-H--------SAKLPALKQLLLDCG----IG 1705
            |.|:...|.|...:               |.||: |        ::|....:||.|..|    :.
 Worm   695 LDKIAKMLCLREKAYADKKWQHVSEDLAWLSDIKIHQLCERFRCTSKFLLNEQLALKSGKCEQLD 759

  Fly  1706 VQTESVSQ--HRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSI 1768
            |....:.:  .:.|||.|..:||||:|..|   ::...:|.||||..|...||:::|.||....:
 Worm   760 VMLPEIQKKGDKVLIFSQFTSMLDILEVYL---NIRGYSYKRLDGQTPVLDRQEMINEFNLSKDL 821

  Fly  1769 DVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKI 1833
            .|.||:|..||||:|||.|:.:|..:.|:||..|.||.||.||:||:|.|:|.||:::.::|..:
 Worm   822 FVFLLSTRAGGLGINLTSANHIIIHDIDFNPYNDKQAEDRCHRMGQEKPVHVTRLVSKGTVEVGM 886

  Fly  1834 MGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASG---------G 1889
            :.|.|.|:.....|.......|......::.: ..||:..|....|..:....||         |
 Worm   887 LALAKKKLQLEKQVTDGVKGQLDEDALRELKE-EEGGEQCGGRDLSKLLSSAISGRYDDVEDDSG 950

  Fly  1890 MSMNTI---------IENLPE-LWSEHQYEEE 1911
            .|.|.|         .|.:.| :..|.|.|||
 Worm   951 DSKNGIDAEEAAKKEDEAVKEPVEKEQQKEEE 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	167/561 (30%)
smrd-1	NP_499301.2	HepA	<393..902	CDD:440319	167/554 (30%)