Protein Alignment Hel89B and isw-1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001379931.1
• Gene: isw-1 / 175944
• WormBaseID: WBGene00002169
• Length: 1009
• Species: Caenorhabditis elegans
• Alignment Length: 664
• Identity: 206/664 - (31%)
• Similarity: 312/664 - (46%)
• Gaps: 104/664 - (15%)

  Fly  1276 PLLGAMSDPDES---------VRLLS-----THCF----ANLVQLMPLD---------------- 1306
            |.:....:|:.|         .|||.     :||.    |.|....|:|
 Worm    29 PSMEVDDEPESSDAADSFKRFERLLQKTENFSHCLSSGDAKLATGAPVDTKKRGRPSKKNGIDGD 93

  Fly  1307 ---GKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYN 1368
               .||||.:.:.:.|...:..:.:.:..:|..|.|        .|:|.||..|:|||..|....
 Worm    94 HRHRKTEQEEDEEMVADAIKSDDLVIFDKSPFYIEN--------GEMRDYQVRGLNWLASLQHNK 150

  Fly  1369 LHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLR 1433
            ::|||.|:||||||||||.::.....::..|:    |.|||.|.:...:|..|.:|:...   :.
 Worm   151 INGILADEMGLGKTLQTISMIGYMKHYKNKAS----PHLVIVPKSTLQNWANEFKKWCPS---IN 208

  Fly  1434 PLHYYGFPVGREKLRSDI--GTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSS 1496
            .:...|....|.::..|:  ..|.::...:|:.:.|.......:::.|.::||.|.|||.|:|.|
 Worm   209 AVVLIGDEAARNQVLRDVILPQKFDVCCTTYEMMLKVKTQLKKLNWRYIIIDEAHRIKNEKSKLS 273

  Fly  1497 KAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQ 1561
            :.::.|.:.:||:::|||:|||:.|||:|.:||:|....:...|...|      |.||.|...:
 Worm   274 ETVRELNSENRLLITGTPLQNNLHELWALLNFLLPDIFTSSDDFDSWF------SNDAMSGNTD- 331

  Fly  1562 EAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKL 1626
                 .::.||:.:.||||||:|.||.|.|.||....:...||.:|...|    .|.|...:|.:
 Worm   332 -----LVQRLHKVLQPFLLRRIKSDVEKSLLPKKEVKVYVGLSKMQREWY----TKVLMKDIDII 387

  Fly  1627 GDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAK 1691
            ..:....        |..:...|.:|:...|||.| ...:|.....|:...|       :::|.|
 Worm   388 NGAGKVE--------KARLMNILMHLRKCVNHPYL-FDGAEPGPPFTTDQHL-------VDNSGK 436

  Fly  1692 LPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQ 1756
            :..|.:||:..     .|..|  |.|||.|...|||::|.....||   ..|.|||||.|...|.
 Worm   437 MVVLDKLLMKF-----KEQGS--RVLIFSQFSRMLDLLEDFCWWRH---YEYCRLDGSTPHEDRS 491

  Fly  1757 DIVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1820
            :.:..:|: |....:.:|||..||||:||..||.||..:.||||..|||||||||||||||.|.|
 Worm   492 NAIEAYNAPDSKKFIFMLTTRAGGLGINLATADVVIIYDSDWNPQSDLQAMDRAHRIGQKKQVRV 556

  Fly  1821 YRLITRNSLEEKIMGLQKFKILTANTVVSAENAS--LQTMGTSQIFDLFNGGKDKGAESGSSAVQ 1883
            :||||.|:::|:|:...:.|:...|.|:.....|  .:|:|...:..:..    .|||...:|..
 Worm   557 FRLITENTVDERIIEKAEAKLRLDNIVIQQGRMSEAQKTLGKGDMISMIR----HGAEQVFAAKD 617

  Fly  1884 GTASGGMSMNTIIE 1897
            .|.|.. .::||:|
 Worm   618 STISDD-DIDTILE 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	174/509 (34%)
isw-1	NP_001379931.1	PLN03142	48..1008	CDD:215601	203/645 (31%)