Protein Alignment Hel89B and btf-1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_496802.2
• Gene: btf-1 / 174965
• WormBaseID: WBGene00000274
• Length: 1649
• Species: Caenorhabditis elegans
• Alignment Length: 2020
• Identity: 511/2020 - (25%)
• Similarity: 833/2020 - (41%)
• Gaps: 480/2020 - (23%)

  Fly     2 TSRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVE 66
            ::||.:|..|||..:.....:||| ..|::..|    ...:.|.|..:..|..||||::|.:.::
 Worm     6 SARLLQLDPLLEAKNPNVRNEAAA-AFGKLSIL----SEDVKNSLKKHAASQLWETRVSAGKALQ 65

  Fly    67 AILKQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILH 131
            |.|:..    |||:.|..               ||||..|....|......|.||...
 Worm    66 ATLQNA----PEFERLKN---------------EEDSSVSENVRSIVVMNVLRSFKPL------- 104

  Fly   132 KGARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDE 196
                          :.:::.|....|:||   ....:||.:::..|....|.  |::.|..::|:
 Worm   105 --------------LSDDESALKKSEKDR---GNNQKQREIVDQHLEYNRAT--GISSTKFLSDD 150

  Fly   197 DVALNRSGSTYNVNAEKLPVEHLLNIKTAANGSGQAPLSCREMNRAKRKARQNTSGCSVTAVTPT 261
            :. |::..|                       ....|.:.:|::....|..
 Worm   151 EF-LHQGIS-----------------------EPDQPSTSKELDEVVTKIE-------------- 177

  Fly   262 CSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLKSTDRQEIFYSLNAAVPDATGTWVDAVSWPL 326
                         .....||.....||. :||.||
 Worm   178 -------------IFDEENGNCDDGIER-QKKFLK------------------------------ 198

  Fly   327 ENFCSRLFIDLFHAK-WEVRHGAATALRELINQHAQGAGKAVLQTREQMDEAHSRWLEDAALRLL 390
               ..|..::|...| |..|||.|.|:.::.:              ...|......::.....|:
 Worm   199 ---VLRELVNLVAEKQWYARHGGAIAICQIAS--------------TSYDRLSYELIDTILYLLI 246

  Fly   391 CVLCLDRFGDFVSDQ-VVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQLIQHKNE--WDVRHG 452
            .||.||:|.||:|.: ..|||||.|||.|..:::..:..:.:.::.|::|:::...|  |::|..
 Worm   247 HVLILDKFNDFISGRNATAPVREQCAQALVHMLRNTDEKRREVVLEIVVQMVRTPGEKNWNIRQS 311

  Fly   453 GLLGLKYVFVVRE----ELLPIYLPQSISNILIGLLDAVDDVGAVAAATLIPVSS--WLPKLLNP 511
            |||.|||.|.:..    |....: .|..:.::..|.|:||||...|..||..:.|  .:|:....
 Worm   312 GLLILKYYFAIARNDGTEHQKTF-NQCFNLVIQSLDDSVDDVTGCAVKTLASILSNKEIPQEEMS 375

  Fly   512 AQVSSIVKMLWDLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPRLWPFLSHSTS 576
            ..|..::..:|.||    :|.:|.......|.| ||:.           .:.:..||...:....
 Worm   376 QLVEKVMSHVWKLL----DLEAAKEQLRAGLDA-LCID-----------LLEIVELWLRWNQHVG 424

  Fly   577 SVRRSTLKTLMTLTSADRVKSEPKDENQVKE--EADKEEMKLNFGVSDWKWELLQQALRHIYQRI 639
            ..|.|.|....|:.:|..|:.|     ::.:  |||.|..:.|...::..:.:::|    :|:.:
 Worm   425 ISRESLLTICSTIDAAFPVRCE-----KIVQLLEADIERPQSNKLSAEDVFIIIKQ----LYRIL 480

  Fly   640 LVEPQADIQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFDAGVLIRAGGDVST 704
            |..|.||                   :||.....|::...........|..:.|::
 Worm   481 LFAPPAD-------------------SLLFLEKTFITFSKIFKCYRQDLLIENGLV--------- 517

  Fly   705 PGSTSRKRTPRIGDELGGNILAQSNASLKLY------LGGSEATPLDV-------------RDAN 750
                    :.:||:.||..:|...|..:.::      :..:.::|.::             :|..
 Worm   518 --------SQKIGNWLGCLLLDHRNPQIDVFACDVDGISSNRSSPTELMCSEEMRFLGEKEKDKV 574

  Fly   751 FMRARISSSRALGALSHYLVQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFW 815
            ::..:|..::.|..:...|.: :.|.:...:.:.....   :.:....:.|.:..:...:|:..|
 Worm   575 YLTRKILCAKFLAIILEALYE-SDGEIQGQRIDIAVQL---LFIPFFQSKSIMHNLGVSIIVNEW 635

  Fly   816 A-----------LEDEP-----------VRPGPPNLQEKLHQCVSEYVYYDEVAISLTRLLQEAQ 858
            |           ||..|           || ||..             .|||:...:..|.::..
 Worm   636 AALYRSGITAKTLEKPPPLTIIQLADGIVR-GPGK-------------QYDEMTTIVMGLTKDCN 686

  Fly   859 DFIATLKQNKIPINDFNNAKILTL-----DQIEAVATTLSENLRSYPLKPKVLDMLEERRRSLQA 918
            :||     ....:..|:.......     |..:|..:.:..||::    .|..:.::.|..:|..
 Worm   687 EFI-----EYCVVRGFDRTSAEARGESPEDVSKAAYSIVRPNLKT----EKQRESIDSRYNTLCR 742

  Fly   919 SYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQ----CLQLQQLSAEFL 979
            |.:.......:..:...|.|:..:......|:||.|.::|::|:::.|:    ..::.:.:...|
 Worm   743 SIENAKMNIKSNGIRINALLSSTLFYFGNAPEKLTPQIRPIVETMQTEENDAMASEVFRGAVPLL 807

  Fly   980 VHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLA 1044
            |...   ..|||.|..|:...........|...|||
 Worm   808 VMFS---WSRNPRPYVKVFAKAFESFSGCPIRMPKL----------------------------- 840

  Fly  1045 LQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQ 1109
                           ||::|       |...|.|..|:|.......   :.....|..:.....:
 Worm   841 ---------------GASSP-------GALEPWTTTIISMRRIWGK---ETDDGFEESSGMISAE 880

  Fly  1110 RLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSM-- 1172
            ...|...:..||:....|:.|....|.          :.|..|  |.:.|..|.:.|.|.:.:
 Worm   881 SRNAELFLNILCQFNASQLAEFYCHFD----------LSEDVD--LNTFLTRLELHNSLWNRVGS 933

  Fly  1173 QLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLP 1237
            :|.:.:|        .::|:|:||..       .|:|:..|:.|....:.....|:....:.|:.
 Worm   934 RLSDQSA--------DKIFSLVPSED-------PAIRYAFAKAIETFFKSSCGDTLSKCYNRLVV 983

  Fly  1238 LLGKIEQLIERQGAIEAIERVVSRLQIKVVPYI----VLLVVPLLGAMSDPDESVRLLSTHCFAN 1298
            |...::.:..|..|:|    |..||.:....|:    .||...:...::|..|:||..:...|..
 Worm   984 LSKDLDNVNSRLSAVE----VFLRLCMMDTRYLNGWATLLAPVIFPLLADQCETVRDAAGEAFRR 1044

  Fly  1299 LVQLMPLDGKTEQLK--SDPLQARKTRDREFLDYLFNPKSIPNYKVPVPI-----SVELRCYQQA 1356
            |:.::.|:.....::  |..|.|:|:....|::.|.:|.|:|.. :...|     :..||.||..
 Worm  1045 LIPVITLENPDFSIEGMSQELLAKKSEYSNFINVLGSPSSLPRV-IRADIRGGFDTSMLREYQLE 1108

  Fly  1357 GINWLWFLNKYNLHGILCDDMGLGKTLQTICILA----GDHM---HRQTANLANLPSLVICPPTL 1414
            ||.|:.||..|.|||||.|||||||||||:|.:|    .|.|   ||        .||::||.||
 Worm  1109 GITWIRFLRTYGLHGILADDMGLGKTLQTMCSIALSVDRDEMSEFHR--------CSLIVCPRTL 1165

  Fly  1415 TGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCN---LVVASYDTVRKDIDFFSGIH 1476
            ..||..|..:|..|          ..|..:..      |:|:   :.|.:||.::  ..:.....
 Worm  1166 VDHWCLEWNRFFPQ----------RVPASKNL------TRCHGAEICVIAYDELK--TAYMMDRV 1212

  Fly  1477 FNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFV 1541
            :||.||||||:::|.|.::.|...:|....||||||||:||:..:|||||.:||||:||:||||.
 Worm  1213 WNYIVLDEGHVMRNSKLRAWKFASQLVGKSRLILSGTPVQNSPADLWSLFAWLMPGYLGSEKQFR 1277

  Fly  1542 QRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPL 1606
            .:|.:.|:..|..|::..:.:||..|:..||:.||||::||:|.:|||:||.|..||..|||:..
 Worm  1278 SQFLKKIMKCRLPKANEADLKAGSAAISQLHKLVLPFVMRRLKTEVLKELPEKNVQDYECELTED 1342

  Fly  1607 QLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTK 1671
            |..:|....::    |.....|...:|:||            |..|:.:.:|.|||   .:.|.|
 Worm  1343 QKEIYRFVVDR----CTSSQEDVGLSSLVT------------LITLRKLTDHTKLV---HDTLAK 1388

  Fly  1672 VTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQ-TESVSQ-----------HRALIFCQLKA 1724
            :.:...:.:.:|  ...|.|:.||||||::|.|... .|.|.|           ||||||||.|.
 Worm  1389 IGAPQYILSKAL--AAKSGKMEALKQLLIECEICKNPDEEVEQPEDLGGLVASGHRALIFCQWKT 1451

  Fly  1725 MLDIVEQDLLRRHLPS-VTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGAD 1788
            ...:|...|......| |::|.|||||||..|..:||.||.|.:||||:|||.|||:||||||||
 Worm  1452 SAKLVSDALKSGEFGSVVSHLVLDGSVPAGDRMKMVNRFNEDKTIDVLILTTHVGGVGLNLTGAD 1516

  Fly  1789 TVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENA 1853
            ||||::|||||||||||:|||||:||.:.||||||||:.::|||:|.|.|||:.||..::.|:|.
 Worm  1517 TVIFLDHDWNPMKDLQAIDRAHRLGQTRNVNVYRLITQGTVEEKVMSLAKFKLNTAQALIGADNT 1581

  Fly  1854 SLQTMGTSQIFDLF--NGGKDKGAESGS--SAVQGTASGGMSMNTIIENLPELWSEHQYEEEYDL 1914
            |:.||.|.::.::|  :|.:.|....|.  :|.:...|.|.....   :|..:|.|.|| :::.:
 Worm  1582 SMMTMETGELMNMFTLDGDEAKKKPGGGEPAAKKSKKSTGAPEEV---DLASMWDESQY-DDFQV 1642

  Fly  1915 GNFVQ 1919
            .:|::
 Worm  1643 DSFLR 1647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787	8/24 (33%)
		HEAT repeat	42..70	CDD:293787	9/27 (33%)
		HEAT repeat	395..420	CDD:293787	15/25 (60%)
		HEAT repeat	433..465	CDD:293787	12/33 (36%)
		HEAT repeat	475..504	CDD:293787	10/30 (33%)
		HEAT repeat	516..540	CDD:293787	5/23 (22%)
		HEAT repeat	560..589	CDD:293787	5/28 (18%)
		DUF3535	654..1138	CDD:463447	78/533 (15%)
		HepA	<1342..1849	CDD:440319	228/534 (43%)
btf-1	NP_496802.2	DUF3535	<572..>792	CDD:463447	40/246 (16%)
		HepA	<1102..1577	CDD:440319	227/521 (44%)