Protein Alignment Hel89B and T23H2.3

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001032980.2
• Gene: T23H2.3 / 172347
• WormBaseID: WBGene00020742
• Length: 1001
• Species: Caenorhabditis elegans
• Alignment Length: 1184
• Identity: 239/1184 - (20%)
• Similarity: 408/1184 - (34%)
• Gaps: 429/1184 - (36%)

  Fly   863 TLKQNKIPINDFNNAKILTLDQIEAVATTLSENLRSYPLKPKVLDMLEER--RRSL-QASYQQTT 924
            |...:|...:|...::....:..|...|.:::.|:... :|:....|.||  |:|: |.|.|..|
 Worm    81 TYGSSKCSTDDHYRSRSFIDNSFEKPVTPITKKLQESD-EPRAKQQLRERLLRKSIKQQSDQDLT 144

  Fly   925 --SEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVC 987
              |.:|.:.....::|..:        |.:|....|:.::.:....|              |...
 Worm   145 GGSSRSGWGTGENSSLESS--------DLINSHFSPIAKTFRHASDL--------------DDSM 187

  Fly   988 DRNPSPNSKILNNLCTLLRSDPEFTPKLVMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTT 1052
            :.:|.||...|.::.|...:.|              |||          |.|
 Worm   188 NTSPPPNRSTLPSVETSSGNSP--------------QTP----------YPG------------- 215

  Fly  1053 NTRSGAGGATTPTATTAPRGPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAI 1117
                      :|.|:..|    .||..        ||. ||:....||.||.:
 Worm   216 ----------SPEASPQP----SPPKN--------TAS-ELQKLSIKELEANK------------ 245

  Fly  1118 EKLCRIFGEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHL 1182
            :|..::.                             :..|.|||.|
 Worm   246 DKKLKLL-----------------------------KFSSNLPDNG------------------- 262

  Fly  1183 HVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIE 1247
                                          ||   |..::|                 :|.:.||
 Worm   263 ------------------------------AR---VKLQVD-----------------EITEEIE 277

  Fly  1248 RQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLD------ 1306
            |        |:::.:       ...:||....|:..|.:.         .||:..:|.|
 Worm   278 R--------RIINGV-------TDTMVVDKTTAIPPPPQP---------KNLIAPIPQDFAAMLD 318

  Fly  1307 --------GKTEQLKSDPLQARKTRDREFLDYLFNPKSIPN----YKVPVPISVELRCYQQAGIN 1359
                    |:..:.|.  |:..|..||..........:||.    ...|..:.|||..:|:||:.
 Worm   319 KNGRKVMSGRMTEQKI--LKVNKISDRLMQQLADATHTIPAETDLTDTPDGLLVELMPHQKAGLR 381

  Fly  1360 WL-WFLNKYNLHGILCDDMGLGKTLQTICIL----------------AGDHMHRQTANLANL-PS 1406
            || |...:.:..|||.|||||||||..:.::                |.|...|:.|....| ||
 Worm   382 WLVWREGQPHSGGILADDMGLGKTLSMLSLIVHQKAARRARKESGDNAADKEKRRVAKEEGLYPS 446

  Fly  1407 ---LVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTV--- 1465
               |:|.|.:|...|..|:.:.| :..:|....::|....|:....:: .:.::|:.:|...
 Worm   447 NGTLIIAPASLIHQWEAEINRRL-ESDLLSVFMFHGTKKQRQIEPKEL-ARYDVVITTYTLAANE 509

  Fly  1466 ---------RKDIDF--------------------FSGIHFNYCVLDEGHIIKNGKTKSSKAIKR 1501
                     :|:.|.                    .:.:.::..:|||.|.|||..::.|||:.|
 Worm   510 LMEKKAAGSKKEEDSDDESENEENPRRPAGKNDSPLARVAWSRVILDEAHAIKNRLSQCSKAVCR 574

  Fly  1502 LKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVL 1566
            |.:..|..||||||.||:.:|:||..||.....|..|.:.:              |....:.|:
 Worm   575 LSSFSRWCLSGTPIHNNLWDLYSLVRFLRIPLFGDRKFWAE--------------SIMPMKTGM- 624

  Fly  1567 AMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYE---------------DFSN 1616
             .:.::......:|||.     ||....:|...:..|...::.::|               :.:.
 Worm   625 -ADRVNLLTKNLMLRRT-----KDQQCALTNKKIVNLKEKKIEIHELEMVGDEANGYAIMMEAAQ 683

  Fly  1617 KHLK------DCLDKLGD-------------SSSASMVTENLSAKTH------IFQALRYLQNVC 1656
            |.:|      |.:.|.|.             ::..::...||:..::      |...|..|:..|
 Worm   684 KLVKQIVTNTDDIQKYGQIRRRRQRGNDDEFANPYNVGPRNLAGNSNFQNMSCILLLLMRLRQAC 748

  Fly  1657 NHPKLV--------------------LRQSEEL-TKVTSQLALSNSSLDDIEHSAKLPALKQLLL 1700
            .|..:.                    :::.|.| .|..:.|.:::|..|:.
 Worm   749 VHFHITKSGMDLDAFKINGGDDEDADMKELENLMEKTMADLTIADSDNDEE-------------- 799

  Fly  1701 DCGIGVQTESVSQHRALIF------CQLKAMLDIVEQ------------------DLLRRHLPS- 1740
              |:....|...|....||      |::...|::|.:                  :|:.:|:.:
 Worm   800 --GVDTNKEEPKQPPTRIFEPDFISCKMAKTLEVVREILEKKEKVVIVSQWTSVLNLVEKHIQAG 862

  Fly  1741 -VTYLRLDGSVPASQRQDIVNNFNSDP-SIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDL 1803
             ..|..:.|.|....||:.|::||.:. ...|:||:...||:||||.|.:.:|.|:..|||..:.
 Worm   863 GHNYTSITGQVLVKDRQERVDSFNQEKGGAQVMLLSLTAGGVGLNLIGGNHLIMVDLHWNPALEQ 927

  Fly  1804 QAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKI-LTANTVVSAENASLQTMGTSQIFDLF 1867
            ||.||.:|:||||.|.::|||.:.::|:::|.||:.|: |.|:.:.......|..:.|:.|..||
 Worm   928 QACDRIYRMGQKKEVFIHRLIVKGTIEQRVMDLQEKKLALAASVLEGTATRKLNKLTTADIRMLF 992

  Fly  1868 NGGKDKGAESGSSA 1881
                  |.:..|:|
 Worm   993 ------GLDGSSNA 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	49/279 (18%)
		HepA	<1342..1849	CDD:440319	152/648 (23%)
T23H2.3	NP_001032980.2	PHA03307	27..>233	CDD:223039	42/234 (18%)
		HepA	<359..973	CDD:440319	152/652 (23%)