Protein Alignment Hel89B and xnp-1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_001020958.1
• Gene: xnp-1 / 172077
• WormBaseID: WBGene00006961
• Length: 1359
• Species: Caenorhabditis elegans
• Alignment Length: 762
• Identity: 171/762 - (22%)
• Similarity: 274/762 - (35%)
• Gaps: 248/762 - (32%)

  Fly  1298 NLVQLMPLDGKTEQLKS---DPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGIN 1359
            :|.:::.......:|||   ||  ...|.|.|..    .|..:.|..|.:     |:.:|..||.
 Worm   419 DLTEMLTGTSSQRKLKSVVLDP--DSSTVDEESK----KPVEVHNSLVRI-----LKPHQAHGIQ 472

  Fly  1360 WLW--------FLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTG 1416
            :::        .|:.....|||...||||||||.|..|....||.:...... ..||:.|..:..
 Worm   473 FMYDCAFESLDRLDTEGSGGILAHCMGLGKTLQVITFLHTVLMHEKIGEKCK-RVLVVVPKNVII 536

  Fly  1417 HWVYEVEKFL-DQGSVLRPL------HYYGFPVGREKLRSDIGTKC-NLVVASYD-----TVRKD 1468
            :|..|.:|:| |....|..:      .|......|..|::...:|. ::::..||     ||..|
 Worm   537 NWFKEFQKWLVDNDEELDTIDVNELDSYKTIEDRRRALKAWHSSKTPSVMIIGYDLFRILTVEDD 601

  Fly  1469 -----------------IDFFSGIHF---NYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGT 1513
                             .||...:..   :..|.||.|.:||..:..||.:.::....|:.|:||
 Worm   602 PKKKKPKNRNRRLEKAKEDFRKYLQNPGPDMVVCDEAHKLKNDDSALSKCMVKILTKRRICLTGT 666

  Fly  1514 PIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPF 1578
            |:|||::|...:.:|:.||.|||:.:|..||...|...|...:|..|               :.|
 Worm   667 PLQNNLMEYHCMVNFVKPGLLGTKTEFANRFVNIINRGRTKDASPLE---------------VSF 716

  Fly  1579 LLRR--VKEDVLKD-------------LPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGD 1628
            :.||  |..|.||.             :|||....:....:..|..||..|.|       |.:||
 Worm   717 MKRRCHVLYDHLKKCVDRKDYRVLTEAIPPKQEYVINVRQTERQCALYNAFLN-------DIVGD 774

  Fly  1629 S--SSASMVTENLSAK--THIFQALRYLQNV---------------------------------- 1655
            |  |...:...::.::  ||.:|.:.:.|.:
 Worm   775 SGLSKRLLPDYHMFSRIWTHPYQLVLHEQRMERERVMREDAEEEADFIDDGDGSESESEGSFKSG 839

  Fly  1656 ------------------------CNHPKLV--------------------------------LR 1664
                                    .|.|::.                                :|
 Worm   840 SESDSGKSVVLSSDDEGSSKKKKNGNKPEIKKTAPQKKRKFLNSDDEDEEDGEDTAMAILQDGIR 904

  Fly  1665 QSEELTKVTSQL-----------------ALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVS 1712
            ||:.|....:.|                 .:.....||...|.||..|.:::..|      |.:.
 Worm   905 QSKRLAGEEADLRDTDTPPEYTGWFARLGLVKEEDRDDFALSNKLILLVEIIKKC------EEIG 963

  Fly  1713 QHRALIFCQ-------LKAMLDIV----------------EQDLLRRHLPSVTYLRLDGSVPASQ 1754
            . :.|:|.|       :|.||:.:                |.:.....|....|:.:||||.:.:
 Worm   964 D-KLLVFSQSLESLTLIKRMLEYMAGTGQWFADGHEALNAEGEETWSWLEGEDYMTIDGSVQSGK 1027

  Fly  1755 RQDIVNNFNSDP---SIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKK 1816
            |..:..:|| ||   ...::|::|..|.||.|:..|:.||..:..|||..|.|::.|.:|.||.|
 Worm  1028 RDAVQTSFN-DPLNLRARLMLISTRAGSLGTNMVAANRVIIFDACWNPSHDTQSLFRVYRFGQTK 1091

  Fly  1817 VVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQI 1863
            .|.:||.|.:.::||:|...|          |:.|:.|::.:..:||
 Worm  1092 PVYIYRFIAQGTMEERIYKRQ----------VTKESTSMRVVDEAQI 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	155/699 (22%)
xnp-1	NP_001020958.1	HepA	<390..1124	CDD:440319	169/756 (22%)
		DEAD-like_helicase_N	463..720	CDD:475120	71/272 (26%)