Protein Alignment Hel89B and Smarca4

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_063120900.1
• Gene: Smarca4 / 171379
• RGDID: 621728
• Length: 1650
• Species: Rattus norvegicus
• Alignment Length: 1270
• Identity: 325/1270 - (25%)
• Similarity: 484/1270 - (38%)
• Gaps: 397/1270 - (31%)

  Fly   770 VQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDEPVRPGP--PNLQEK 832
            |.||...|..|||:||                                 .:|.:|.|  |
  Rat   318 VPPAASPVMPPQTQSP---------------------------------GQPAQPAPLVP----- 344

  Fly   833 LHQCVSEYVYYDEVAISLTRLLQEAQDFIATLKQNKI-PINDFNNAKILTLDQIEAVATTLSENL 896
            |||                             ||::| ||.
  Rat   345 LHQ-----------------------------KQSRITPIQ------------------------ 356

  Fly   897 RSYPLKPKVLD---MLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKL--NPVV 956
                 ||:.||   :|:||...|                  ||.:|..|..|..||..|  :...
  Rat   357 -----KPRGLDPVEILQEREYRL------------------QARIAHRIQELENLPGSLAGDLRT 398

  Fly   957 KPLMESIKREQCLQLQ-QLSAEFLVHLMDQVCDRNPSP-----NSKILNNLCTLLRSDPEFTPKL 1015
            |..:| :|..:.|..| ||..|.:      ||.|..:.     |:|...........:...|.||
  Rat   399 KATIE-LKALRLLNFQRQLRQEVV------VCMRRDTALETALNAKAYKRSKRQSLREARITEKL 456

  Fly  1016 VMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGE 1080
            .      ||..:..|......:...|...||.....                   |...|..||:
  Rat   457 E------KQQKIEQERKRRQKHQEYLNSILQHAKDF-------------------REYHRSVTGK 496

  Fly  1081 ILSATNATA--HIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKV 1143
            :...|.|.|  |...:.:|.||.|    ||::       |::.|:..|.  |:          ..
  Rat   497 LQKLTKAVATYHANTEREQKKENE----RIEK-------ERMRRLMAED--EE----------GY 538

  Fly  1144 EQFVKEAYDWRLGSLL--PDLGVCN--ELVSSMQLIETA--------------APHLHVALHP-- 1188
            .:.:.:..|.||..||  .|..|.|  |||...:..:.|              |.....|:.|
  Rat   539 RKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDG 603

  Fly  1189 -------QMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLI 1246
                   ||..|          |:|.:...:.:   :|...||            |..|::|..:
  Rat   604 EPLDETSQMSDL----------PVKVIHVESGK---ILTGTDA------------PKAGQLEAWL 643

  Fly  1247 ERQGAIEAIERVVSR------------------LQIKVVPYIVLLVVPLLGAMSDP--DESVRLL 1291
            |.....|...|..|.                  .|...:|......:|      ||  |:...:.
  Rat   644 EMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTLPVEEKKKIP------DPDSDDVSEVD 702

  Fly  1292 STHCFANLVQLMPLDGKTEQLKSDPLQ-----ARKTRDREFLDYLFNPKSIPNYKVPVPISVELR 1351
            :.|...|..|.:..:....|..:..||     |....:|            .:.:..:.::..|:
  Rat   703 ARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTER------------VDKQSALMVNGVLK 755

  Fly  1352 CYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTG 1416
            .||..|:.||..|...||:|||.|:||||||:|||.::.....|::    .|.|.|:|.|.:...
  Rat   756 QYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKR----INGPFLIIVPLSTLS 816

  Fly  1417 HWVYEVEKFLDQGSVLRPLHYYGFPVGRE----KLRSDIGTKCNLVVASYDTVRKDIDFFSGIHF 1477
            :|.||.:|:..  ||:: :.|.|.|..|.    :|||.   |.|:::.:|:.:.||....:.|.:
  Rat   817 NWAYEFDKWAP--SVVK-VSYKGSPAARRAFVPQLRSG---KFNVLLTTYEYIIKDKHILAKIRW 875

  Fly  1478 NYCVLDEGHIIKNGKTKSSKAIK-RLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFV 1541
            .|.::||||.:||...|.::.:. ...|..||:|:|||:||.:.|||:|.:||:|....:...|.
  Rat   876 KYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFE 940

  Fly  1542 QRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPL 1606
            |.|:.|...:.: |....|:|. :|.:..||:.:.||||||:|::|...||.|:...:.|::|.|
  Rat   941 QWFNAPFAMTGE-KVDLNEEET-ILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSAL 1003

  Fly  1607 QLRLYE----------DFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKL 1661
            |..||.          |.|.|      ||.|...:.:::           ..:..|:.:||||.:
  Rat  1004 QRVLYRHMQAKGVLLTDGSEK------DKKGKGGTKTLM-----------NTIMQLRKICNHPYM 1051

  Fly  1662 VLRQSEELTK-------VTSQLALSNSS-----LDDIEHSAKLPALKQLLLDCGIGVQTESVSQH 1714
            .....|..::       :...|.|..:|     ||.|     ||.|:              .:.|
  Rat  1052 FQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRI-----LPKLR--------------ATNH 1097

  Fly  1715 RALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMV 1777
            :.|:|||:.:::.|:|.....|   ...||||||:..|..|..::..|| :|..:  :.||:|..
  Rat  1098 KVLLFCQMTSLMTIMEDYFAYR---GFKYLRLDGTTKAEDRGMLLKTFN-EPGSEYFIFLLSTRA 1158

  Fly  1778 GGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKIL 1842
            |||||||..|||||..:.||||.:||||.||||||||:..|.|.||.|.||:||||:...|:|:.
  Rat  1159 GGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLN 1223

  Fly  1843 TANTVVSA-----------ENASLQTMGTSQIFDLFNGGKDKGAE----SGSSAVQGTASGGMSM 1892
            ....|:.|           ..|.||.:       |.:..:|:...    |||::...||.....:
  Rat  1224 VDQKVIQAGMFDQKSSSHERRAFLQAI-------LEHEEQDESRHCSTGSGSASFAHTAPPPAGV 1281

  Fly  1893 NTIIENLPELWSEHQ-------------YEEEYDL 1914
            |..:|. |.|..|.:             :|||:||
  Rat  1282 NPDLEE-PPLKEEDEVPDDETVNQMIARHEEEFDL 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	77/383 (20%)
		HepA	<1342..1849	CDD:440319	183/535 (34%)
Smarca4	XP_063120900.1	None