DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and Smarcad1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001342179.1	Gene:	Smarcad1 / 13990	MGIID:	95453	Length:	1021	Species:	Mus musculus

Alignment Length:	551	Identity:	194/551 - (35%)
Similarity:	289/551 - (52%)	Gaps:	74/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1347 SVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICP 1411
            |:.|:.||:.|:|||..::|:.|:|||.|:||||||:|.|..||  ::. |..|..  |.|::.|
Mouse   489 SLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLA--YLF-QEGNKG--PHLIVVP 548

  Fly  1412 PTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTK---CNLVVASYD---TVRKDID 1470
            .:...:|:.||..:...   |..|.|||....|:::|.:|..|   .|::|.:|:   :...|..
Mouse   549 ASTIDNWLREVNLWCPS---LNVLCYYGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRS 610

  Fly  1471 FFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLG 1535
            .|..:..||.:.||||::||..:...:.:..:.|.:||:|:|||:|||:|||.||.:|:||....
Mouse   611 LFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFS 675

  Fly  1536 TEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVL-PFLLRRVKEDVLKDLPPKITQDL 1599
            :....::|    :.||:  ...|.||........|..:|:: ||:||||||:|||.||||..:..
Mouse   676 SSTSEIRR----MFSSK--TKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKDRIE 734

  Fly  1600 LCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLR 1664
            ||.:|..|.:||....|: ||..::             ||...|.:...:..|:.:.||| |:.|
Mouse   735 LCAMSEKQEQLYSGLFNR-LKKSIN-------------NLEKNTEMCNVMMQLRKMANHP-LLHR 784

  Fly  1665 Q--SEELTKVTSQLAL-------SNSSL--DDIE---------------HSAKLPALKQLLLDCG 1703
            |  :.|..|..|||.|       :|..|  :|:|               |.........|:||.|
Mouse   785 QYYTPEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSYQLDMDLILDSG 849

  Fly  1704 ----IGVQTESVSQ--HRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNF 1762
                :|.....:.|  .|.::|.|...||||:|. ||:.|  ...||||||....|:|..:::.|
Mouse   850 KFRALGCILSELKQKGDRVVLFSQFTMMLDILEV-LLKHH--QHRYLRLDGKTQISERIHLIDEF 911

  Fly  1763 NSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRN 1827
            |:|..|.|.||:|..||||:|||.|:.||..:.|.||..|.||.||.||:||.|.|.|.:||::.
Mouse   912 NTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQG 976

  Fly  1828 SLEEKIMGL--QKFKI-LTANTVVSAENASL 1855
            ::||.::.:  ||.|: ....||..|:..|:
Mouse   977 TIEESMLKINQQKLKLEQDMTTVDEADEGSM 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787
		SNF2_N	1353..1662	CDD:278600	109/315 (35%)
		DEXDc	1370..1514	CDD:238005	49/149 (33%)
		Helicase_C	1689..1813	CDD:278689	53/129 (41%)
Smarcad1	NP_001342179.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..151
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..246
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..366
		PLN03142	471..>993	CDD:215601	190/535 (36%)
		DEXHc_SMARCAD1	492..674	CDD:350756	71/189 (38%)
		DEGH box	623..626		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	716..733		12/16 (75%)
		DEAD box	1000..1003		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920