Protein Alignment Hel89B and kis

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_061512916.1
• Gene: kis / 1277495
• VectorBaseID: AGAMI1_002666
• Length: 6890
• Species: Anopheles gambiae
• Alignment Length: 2161
• Identity: 452/2161 - (20%)
• Similarity: 745/2161 - (34%)
• Gaps: 655/2161 - (30%)

  Fly    16 STAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEA-----------IL 69
            |.:..|.|..:|:.::.||...:....:.|:         :.|:|..|..||           ||
Mosquito  1466 SHSQERAAIKQQMQDMYKLPMADNQEKMMRM---------QERLAMLQQHEADGCQGLGPQPCIL 1521

  Fly    70 KQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQ-----SSGSNSTTAS----------ERLL 119
            .|.|  .|.:.|.|    ..|:.|.|||||..||.|     ..|...|.:|          ::||
Mosquito  1522 MQPP--HPLYPVAP----TMTSAAAAAAAAMIDSPQVTSTTGRGRGRTPSSKPRKPRAKKGDKLL 1580

  Fly   120 SFDEFDLQQILHKGARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTT--- 181
            :     .|:.....|.::|..|        ...||......:|....|...|    ..|:||
Mosquito  1581 A-----QQEAAVAAATVVGQTG--------LITSGDETSQSNLVMPFSGAPA----PTGMTTPTP 1628

  Fly   182 ---------AAKLGVNLTDMITD-----EDVALNRSGSTY------NVNAEKLPVEHLLNIKTAA 226
                     :...|..|.::..|     |.::|..||...      :::.:.|......::.|:.
Mosquito  1629 TTLLPVSEDSVTAGTGLPEVSPDGSSFHELMSLESSGGAIGAAGAGDLSQDNLSCSGTGDLDTST 1693

  Fly   227 NGSGQAPLSCREMNRAKRKARQNTSGCSVTAVTPTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPE 291
            :.||:.....|:....|:.|:...:..:.....|| .::.|....|..|            ::.:
Mosquito  1694 DASGKKIKKPRKPREPKKPAKGAAAAAADGVKEPT-PKKESKKKDSKDS------------KKKK 1745

  Fly   292 KKKLKSTDRQEIFYSLNAAVPDA----------TGTWVDAVSWPLENFCSRLFIDLFHAKWEVRH 346
            ||.:.|:|..... |:...:||.          :||......   ||   :....|.:|:.....
Mosquito  1746 KKSVASSDGDNSM-SMEDELPDGGITGDLELSKSGTTTSETD---EN---QSLASLMNAQNSNDA 1803

  Fly   347 GAATALRELINQHAQGA--GK----AVLQTREQMDEAHSRWLEDAALRLLCVLCLDRFGDFVSDQ 405
            .||....|::.:...|.  ||    |.:.|..:..|:..:...|||
Mosquito  1804 NAAAPSTEMVVEGGVGTEDGKEESAAAVATTSEAVESTEKEAGDAA------------------- 1849

  Fly   406 VVAPVRETCAQVLG--TLVKEMEASKVQRIVNILLQLIQHKNEWDVRHGGLLGLKYVFVVREELL 468
                   |.:...|  .:.||.|.|.....|         |:..|  |.|
Mosquito  1850 -------TSSNADGEAEVAKEDEVSAPNASV---------KDGED--HEG--------------- 1881

  Fly   469 PIYLPQSISNILIGLLDAVDDVGAVAAATL-----------IPVSSWLPKLLNPAQVSSIVKMLW 522
                         |.:|..||....||.|.           :|:.....  .:...||.|.|.
Mosquito  1882 -------------GEVDGGDDQSKAAAITTTSEATEGSGSGVPMEEVTD--FDDIPVSKISKT-- 1929

  Fly   523 DLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPRLWPFLSHSTSSVRR------- 580
            :...::||...|...  |..|            |.||..       |..|.|..|.::
Mosquito  1930 EPTKEEDEKKEAAEE--GATA------------EPEPET-------PTKSKSKKSSKKSKEPGSE 1973

  Fly   581 -------------------STLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWE 626
                               |:.::..:.:|....||..:....:..|:|        |..|   :
Mosquito  1974 GGSSSSSRNRSRPSGGGSSSSRRSGGSKSSGGGSKSRSRRSRMIVTESD--------GEGD---D 2027

  Fly   627 LLQQALRHIYQRILVEPQADIQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFD 691
            ||...        ...|..|::|.:.:..|                         :....|..:.
Mosquito  2028 LLSTP--------PPSPPPDMEADSSKRRS-------------------------ARNTQRKKYV 2059

  Fly   692 AGVLIRAGGDVS---TPGSTSRKRTPRIGDELGGNILAQSNASLKLYLGGSEATPLDVRDANFMR 753
            ..|::|...|.|   :| :.|..|..|..|  ||:...:..|..::.|.|.||..: ..|.:...
Mosquito  2060 DDVMLRFSDDESGMMSP-APSGSRKDRRSD--GGSDRKEGLAPTEVALAGGEAGAV-AADGSVAG 2120

  Fly   754 ARISSSRALGALSHYL-----------VQPAPGVVYTPQTESPTDCYTK-----VLLGHLNAHSA 802
            ....:|..:|..|...           .:.||..|.......|.|..:|     |.:......|.
Mosquito  2121 VAGEASSVVGTGSEQAGDENKVSTSEGAKAAPEAVELGPDGKPIDDSSKPNANYVYVNTSEEDSM 2185

  Fly   803 VQRIVCGLIIAFWALEDEPVRPGPP---NLQEKLHQCVSEYVYYD-------------------- 844
            |.:.|  |.:.....|.:|..|.||   ...|.......|.|..:
Mosquito  2186 VVQYV--LAVRKGRRELKPDPPPPPPKEKTPEPAEGSAEEAVKSEPKEGEEKAAAVGDGSETTAA 2248

  Fly   845 ------------EVAISLTRLLQEAQDFIA-----------TLKQNKIPINDFNNAKILTLDQIE 886
                        ||:.......:||:|..|           |.....:|:......| .|.::|.
Mosquito  2249 EATVKEEGKELKEVSEDGEDKKKEAEDVDASGEVADKEAAPTTTATDVPMETSEETK-STEEKIS 2312

  Fly   887 AVATTLSENLRSYP-LKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPD 950
            ..:.|  .|..:.| .||...|       :.:|..:..|.||.:..|:|               :
Mosquito  2313 PESDT--ANTGAEPEQKPSAED-------ASKAEEKMETDEQESVGVAA---------------E 2353

  Fly   951 KLNPVVKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKL 1015
            |..|..:...|. |:|....:.|...:      :.|.|...:..|
Mosquito  2354 KDTPAEEKEGEE-KKEASADVDQQQVK------EPVADAATAKES-------------------- 2391

  Fly  1016 VMPLETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGE 1080
               :||..:.|..:|.:|        |.|..:|....|..        |.....|......|..|
Mosquito  2392 ---METDAEEPPKTESVN--------TAAEDKTAEQPNGE--------PAVEEKPARVADKPEAE 2437

  Fly  1081 ILSATNATAHIELKAQQAKEAEAKQCRIQRLGAAC-AIEKLCRIFGEQIIEKVAVFQHLMFGKVE 1144
               ||.|||....|.:...|:|..:.:.:...||. .::|.....||...||.:          |
Mosquito  2438 ---ATEATADGVEKMEVEGESEGTEKKPEGDDAAADVVKKESAEGGESTDEKSS----------E 2489

  Fly  1145 QFVKEAYDWRLGSLLPDLGVCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIVC------H 1203
            ...||..:                .:|.:..|.....:::.:. :.|....:..::.|      .
Mosquito  2490 AVKKEEGE----------------SASTETDEKKPEPVYIDVE-EYFVKYRNFSYLHCEWRTEDE 2537

  Fly  1204 PLKAVRHMAARCIAVLAEIDACQTMQFVVHDLL------PLLGKIEQLIERQGAIEAIERVVSRL 1262
            .||..:.:..:....|.:    |..|..:.:.|      |...:::::::....::...:.|...
Mosquito  2538 LLKGDKRVGNKIKRFLMK----QQQQLNIFESLDEEPFNPDFVEVDRVLDVSELVDDEGKTVKHY 2598

  Fly  1263 QI--KVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSD---------P 1316
            .:  |.:||               ::|.              ..|:...:|||.:         |
Mosquito  2599 LVKWKSLPY---------------EDST--------------WELEDDVDQLKIEQYYKFNKIPP 2634

  Fly  1317 LQARKTRDREFLD-YLFNPKSIPNYKVPVPISVELRCYQQAGINWL---WFLNKYNLHGILCDDM 1377
            ....||:.|...| :...|:| |.:|.    ..:||.||..|:|||   |:  |.| :.||.|:|
Mosquito  2635 KSEWKTKKRPHPDQWKALPES-PTFKG----GNKLRPYQLEGLNWLRYSWY--KGN-NCILADEM 2691

  Fly  1378 GLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPV 1442
            |||||:|::..:...:.:....     |.|||.|.:...:|..|.|.:.:...::    |:|...
Mosquito  2692 GLGKTIQSLTFVNSVYEYGIRG-----PFLVIAPLSTIPNWQREFEGWTEMNVIV----YHGSAT 2747

  Fly  1443 GRE--------------KLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKT 1493
            .|:              ||..|| ||.|:::.:::.:..|........:..||:||.|.:||...
Mosquito  2748 SRQMIQDYEVHYRTETGKLIRDI-TKFNVLITTFEMIVTDYQDLKNFTWRACVIDEAHRLKNRNC 2811

  Fly  1494 KSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSA 1558
            |..:.:::|...||::|||||:||||.||:||.:||.|......::|::.|            .:
Mosquito  2812 KLLEGLRQLNLEHRVLLSGTPLQNNVNELFSLLNFLEPSQFACSEEFLREF------------GS 2864

  Fly  1559 KEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCL 1623
            .:.|:.||.::||   :.|.:|||:|:||.|.|.||....:..||:.:|.:.|.....::....:
Mosquito  2865 LKTESEVLKLQAL---LKPMMLRRLKDDVEKSLAPKEETIVEVELTNIQKKYYRGILEQNFSFLM 2926

  Fly  1624 DKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEH 1688
            .   .::||::        .::...:..|:..|.||.|:                 |.:.|.|::
Mosquito  2927 K---GTTSANI--------PNLMNTMMELRKCCIHPYLL-----------------NGAEDQIQY 2963

  Fly  1689 SAKL-------PALKQLLLDCGIGVQTESV------SQHRALIFCQLKAMLDIVEQDLLRRHLPS 1740
            ..:.       ...|.|::..|..|..:.:      :.||.|||.|:...|||:|..|:.:..|
Mosquito  2964 DYRQQHGEDAESYYKNLIVSSGKMVLIDKLLPKLRANGHRVLIFSQMVRCLDILEDYLMYKKYP- 3027

  Fly  1741 VTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDL 1803
              :.|:||.:..:.||..::.: |.|..|  |.||.|..||||:|||.|||||..:.||||..||
Mosquito  3028 --FERIDGRIRGNLRQAAIDRY-SKPDSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDL 3089

  Fly  1804 QAMDRAHRIGQKKVVNVYRLITRNSLEEKI-------MGLQKFKILTANTVVSAENASLQTMGTS 1861
            ||..|.|||||:|:|.:|||:.||:.|.::       :||.|..:.:.||..:.:....| :...
Mosquito  3090 QAQARCHRIGQQKMVKIYRLLCRNTYEREMFDKASLKLGLDKAVLQSMNTGQNKDGTQRQ-LSKK 3153

  Fly  1862 QIFDLFNGG-------KDKG----------------------AESGSSAVQGTASGGMSMNTIIE 1897
            :|.||...|       .|.|                      :|.||:..:.:.:...:.:.|..
Mosquito  3154 EIEDLLKKGAYGAVMDDDAGDKFCEEDIDSILLRRTQVITMESEKGSTFSKASFAASANRSDINI 3218

  Fly  1898 NLPELWSEHQYEEEYD 1913
            :.|:.|::...:.|.|
Mosquito  3219 DDPDFWNKWAKKAEID 3234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787	4/13 (31%)
		HEAT repeat	42..70	CDD:293787	7/38 (18%)
		HEAT repeat	395..420	CDD:293787	2/26 (8%)
		HEAT repeat	433..465	CDD:293787	5/31 (16%)
		HEAT repeat	475..504	CDD:293787	8/39 (21%)
		HEAT repeat	516..540	CDD:293787	5/23 (22%)
		HEAT repeat	560..589	CDD:293787	5/54 (9%)
		DUF3535	654..1138	CDD:463447	101/550 (18%)
		HepA	<1342..1849	CDD:440319	166/545 (30%)
kis	XP_061512916.1	None